Determinants of Patient’s Global Assessment of Disease Activity and Physician’s Global Assessment of Disease Activity in patients with rheumatoid arthritis: A <i>post hoc</i> analysis of overall and Japanese results from phase 3 clinical trials

Kaneko, Yuko; Takeuchi, Tsutomu; Chen, Zhihong; Sato, Masayo; Awakura, Kenta; Gaich, C.; Zhu, Baojin; Guo, Jiaying; Tanaka, Yoshiya

doi:10.1080/14397595.2017.1422304

Cited by 21 publications

(9 citation statements)

References 22 publications

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“…In the DAS28‐CRP, a patient's global assessment (PGA) is included in the four components. PGA is closely correlated with a patient's pain . It can therefore be expected that DAS28‐CRP and PS‐VAS might be closely correlated.…”

Section: Discussionsupporting

confidence: 78%

Influence of pain score measured by a visual analog scale (PS‐VAS) on the Health Assessment Questionnaire Disability Index and 28‐joint Disease Activity Index with C‐reactive protein in rheumatoid arthritis patients

Yoshii¹,

Chijiwa

Sawada

2018

Int J of Rheum Dis

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Section: Discussionsupporting

confidence: 78%

Influence of pain score measured by a visual analog scale (PS‐VAS) on the Health Assessment Questionnaire Disability Index and 28‐joint Disease Activity Index with C‐reactive protein in rheumatoid arthritis patients

Yoshii¹,

Chijiwa

Sawada

2018

Int J of Rheum Dis

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“…This distance between points of view was also found in several other studies. In general, pain and/or physical function were associated with poorer patient assessment in the vast majority of studies [3,8,10,11,13,[23][24][25][26][27][28][29], whereas NSJ and/or abnormal acute inflammation tests were more frequent determinants of worse physician's assessments [8][9][10][11]13,26,27,29]. Numerous potential causes for this discordance have been identified, particularly pain due to inflammatory and non-inflammatory processes different from RA, fatigue, functional disability, depression, psychological stress, low health literacy, and patient-physician communication problems [6,9,10,26].…”

Section: Plos Onementioning

confidence: 99%

Discordance between the patient’s and physician’s global assessment in rheumatoid arthritis: Data from the REAL study—Brazil

et al. 2020

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Background Discordance between patient's global assessment (PtGA) and physician's global assessment (PhGA) has been described in rheumatoid arthritis (RA). Understanding the reasons for this discrepancy is important in the context of treat-to-target treatment strategy. Objective To assess the determinants of PtGA and PhGA and factors associated with discordance between them. Methods The REAL study included RA patients from Brazilian public health centers. Clinical, laboratory and outcomes measures were collected. PtGA and the PhGA were rated on a visual analog scale and analyzed. Three groups were defined: no discordance (difference between PtGA and PhGA within 3 cm), positive discordance (PtGA exceeding PhGA by >3 cm), and

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“…Older patients tend to have more comorbidities associated with polymedication and a higher risk of adverse effects, which can negatively affect their QoL. A post hoc analysis of two clinical trials of baricitinib by Kaneko et al concluded that patients over 65 years of age experienced less improvement in pain after treatment 28. The study by Boubouchairopoulou et al also concluded that younger patients showed the greatest benefit in QoL with biologic antirheumatic therapy 19…”

Section: Discussionmentioning

confidence: 99%

Improvement in RAID questionnaire results in patients with rheumatoid arthritis treated with advanced therapies

et al. 2022

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ObjectivesTo analyse the changes in patient-reported outcomes after starting advanced antirheumatic treatment.MethodsThe study included all patients who started self-administered biological or targeted synthetic treatments for rheumatoid arthritis between February and November 2020. The patients were given the RAID quality of life questionnaire to complete before starting the treatment and after 4 months. Univariate and multivariate analyses were performed to determine the association between patients' clinical and sociodemographic characteristics and quality of life improvement. The level of significance was set at 0.05.ResultsForty-six patients were included. Their ratings in the RAID questionnaire were improved after 4 months of treatment, both in the final overall total, which improved by 1.63±2.29 points, and in the different subtopics of the questionnaire (range 0–10). Pain was the domain that improved the most (2.33±2.82 points), followed by functional disability (2.15±2.51) and physical well-being (1.96±3.18). The improvement was statistically significant in all domains except the sleep score, which showed no statistically significant difference between the two time points analysed.ConclusionsAdvanced antirheumatic treatment improves the quality of life of patients after 4 months of treatment.

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Determinants of Patient’s Global Assessment of Disease Activity and Physician’s Global Assessment of Disease Activity in patients with rheumatoid arthritis: A post hoc analysis of overall and Japanese results from phase 3 clinical trials

Cited by 21 publications

References 22 publications

Influence of pain score measured by a visual analog scale (PS‐VAS) on the Health Assessment Questionnaire Disability Index and 28‐joint Disease Activity Index with C‐reactive protein in rheumatoid arthritis patients

Influence of pain score measured by a visual analog scale (PS‐VAS) on the Health Assessment Questionnaire Disability Index and 28‐joint Disease Activity Index with C‐reactive protein in rheumatoid arthritis patients

Discordance between the patient’s and physician’s global assessment in rheumatoid arthritis: Data from the REAL study—Brazil

Improvement in RAID questionnaire results in patients with rheumatoid arthritis treated with advanced therapies

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