Determinants of participation in state-of-the-art cancer prevention, early detection/screening, and treatment trials among African-Americans

Millon‐Underwood, Sandra

doi:10.1097/00002820-199302000-00002

Cited by 91 publications

(48 citation statements)

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“…Fourteen attitude statements 25,31 were presented with a five-point, ''strongly disagree'' to ''strongly agree'' rating scale. As in Mouton et al, the responses ''strongly agree'' and ''agree'' were combined to reflect agreement.…”

Section: Methodsmentioning

confidence: 99%

African American Women's Perceptions and Attitudes Regarding Participation in Medical Research: The Mayo Clinic/The Links, Incorporated Partnership

Brewer

Hayes

Parker

et al. 2014

Journal of Women's Health

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Objective: To examine perceptions and attitudes toward health-related research participation among professional African American women. Methods: Participants were members of an African American women's service organization, The Links, Incorporated. Data were collected via self-administered questionnaires at The Links, Incorporated 2012 National Assembly. Sociodemographics, prior research experience, intention to participate (ITP), willingness to participate (WTP) in a variety of research studies and attitudes about research participation were measured.

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Section: Methodsmentioning

confidence: 99%

African American Women's Perceptions and Attitudes Regarding Participation in Medical Research: The Mayo Clinic/The Links, Incorporated Partnership

Brewer

Hayes

Parker

et al. 2014

Journal of Women's Health

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“…[42][43][44] Some potential participants may fear discovering that they are at risk for developing disease, have concerns about insurance coverage if they participate in a clinical trial, or are suspicious of research due to the Tuskegee Syphilis Study and other negative historical occurrences. [42][43][44][45][46][47][48][49][50][51][52][53][54] The Tuskegee Syphilis Study was administered in Macon County, Alabama, from 1932 to 1972 and involved 600 black men: 399 with syphilis and 201 without the disease. 55 In addition to failing to obtain adequate informed consent, when penicillin became the drug of choice for syphilis in 1947, researchers did not offer treatment or inform the men that they could quit the study.…”

Section: Clinical Trial Participation and Health Disparitiesmentioning

confidence: 99%

Health disparities: A barrier to high-quality care

Mullins

Blatt²,

Gbarayor³

et al. 2005

American Journal of Health-System Pharmacy

104

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Purpose-Disparities in the treatment of cardiovascular disease, diabetes mellitus, and cancer among the sexes and racial groups and possible interventions are discussed.Summary-The ongoing process to identify and reduce health disparities has engaged numerous federal agencies as they monitor the nation's progress toward policy-driven and health-related objectives. Cardiovascular disease disproportionately affects minority groups and is the leading cause of death among women in the United States, and both groups receive suboptimal care for the disease. Disparities in the treatment of diabetes mellitus in African Americans, women, patients with less than a high school education, and the elderly have been found. Many minority groups continue to suffer disproportionately from cancer. Racial disparities also exist in cancer screening and treatment. Minorities are underrepresented in clinical trials for multiple reasons, many of which may be related to cultural beliefs. At all levels of coinsurance, the poor are less likely to seek preventive care. Adherence to national screening and treatment guidelines, clinical trial recruitment and participation, addressing language and geographic barriers, and increasing access to insurance are part of the coordinated efforts required to reduce health disparities. Because pharmacists influence patients' health status directly through pharmaceutical care and indirectly by engaging patients in their treatment, it is essential for pharmacists to be able to provide culturally competent care.Conclusion-Despite significant efforts over the past several years, health disparities continue to exist, particularly among minority groups. Interventions aimed at eliminating these disparities should include ensuring cultural competence among health care providers and improving health literacy among patients.

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“…Moreover, some of the available evidence is conflicting. For example, mistrust has been identified as an important barrier to research participation among African Americans [3][4][5][6][7] in some studies, whereas in others African Americans have been shown to be willing to participate in clinical research investigations [8][9][10][11] with enrollment rates similar to non-Hispanic whites [12]. A better understanding of factors that influence participation of ethnic and racial minority populations in clinical research studies may enable the development of more effective recruitment strategies, thereby enhancing the generalizability of the findings from these investigations.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with enrollment of African Americans into a clinical trial: Results from the African American study of kidney disease and hypertension

Gadegbeku

Stillman

Huffman

et al. 2008

Contemporary Clinical Trials

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Recruitment of diverse populations into clinical trials remains challenging but is needed to fully understand disease processes and benefit the general public. Greater knowledge of key factors among minority populations associated with the decision to participate in clinical trials may facilitate recruitment and enhance the generalizibility of study results. Therefore, during the recruitment phase of the African American Study of Kidney Disease and Hypertension (AASK) trial, we conducted a telephone survey, using validated questions, to explore potential facilitators and barriers of research participation among eligible candidates residing in seven U.S. locations. Survey responses included a range of characteristics and perceptions among participants and non-participants and were compared using bivariate and step-wise logistic regression analyses.One-hundred forty-one respondents (70 trial participants and 71 non-participants) completed the survey. Trial participants and non-participants were similar in multiple demographic characteristics and shared similar views on discrimination, physician mistrust, and research integrity. Key group differences were related to their perceptions of the impact of their participation. Participants associated enrollment with personal and societal health benefits, while non-participants were influenced by the health risks. In a step-wise linear regression analysis, significant positive predictors of participation were acknowledgement of health status as important in the enrollment decision (OR=4.54, p=0.006), employment (OR=3.12, p=0.05) and healthcare satisfaction (OR=2.12, p<0.01). Racially-based mistrust did not emerge as a negative predictor and subjects' decisions were not influenced by the race of the research staff.In conclusion, these results suggest that health-related factors, and not psychosocial perceptions, have predominant influence on research participation among African Americans.

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Determinants of participation in state-of-the-art cancer prevention, early detection/screening, and treatment trials among African-Americans

Cited by 91 publications

References 0 publications

African American Women's Perceptions and Attitudes Regarding Participation in Medical Research: The Mayo Clinic/The Links, Incorporated Partnership

African American Women's Perceptions and Attitudes Regarding Participation in Medical Research: The Mayo Clinic/The Links, Incorporated Partnership

Health disparities: A barrier to high-quality care

Factors associated with enrollment of African Americans into a clinical trial: Results from the African American study of kidney disease and hypertension

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