Determinants of Outcome Following Surgery for Oral Squamous Cell Carcinoma

Woolgar, Julia A.; Hall, Gillian

doi:10.2217/14796694.5.1.51

Cited by 24 publications

(16 citation statements)

References 113 publications

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“…1 The complex, dynamic and reactive mixture of an estimated 7000 chemicals affects every organ system in the body and causes a wide spectrum of cardiovascular and chronic obstructive pulmonary diseases as well as various types of cancer, in particular oral and lung cancer. [2][3][4] Epigenetic information is defined as information other than the DNA sequence that is faithfully replicated upon somatic cell replication. It is carried by DNA methylation, post-translational histone modifications, and non-coding RNAs, all of which are related to gene expression and chromatin structure.…”

Section: Introductionmentioning

confidence: 99%

DNA methylation analysis of cancer-related genes in oral epithelial cells of healthy smokers

Oliveira¹,

Silva²,

Mariz³

et al. 2015

Archives of Oral Biology

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Section: Introductionmentioning

confidence: 99%

DNA methylation analysis of cancer-related genes in oral epithelial cells of healthy smokers

Oliveira¹,

Silva²,

Mariz³

et al. 2015

Archives of Oral Biology

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“…Cervical lymph node metastases are widely accepted as the strongest independent prognostic factor in patients with OSCC [12][13][14][15][16]. There is a positive correlation between the size of the primary tumour and the appearance of lymph node metastases, although some patients with small tumours have lymph node metastases, whereas patients with large tumours do not develop lymph node metastases [17].…”

Section: Introductionmentioning

confidence: 99%

Impact of podoplanin expression in oral squamous cell carcinoma: clinical and histopathologic correlations

et al. 2010

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Cervical lymph node metastases reduce the overall survival of patients with oral squamous cell carcinoma (OSCC) and require a neck dissection. However, elective management of a clinical N0 neck remains a controversial topic, as there are no reliable factors available predicting cervical lymph node metastases. Recent studies suggest an impact of podoplanin expression on metastatic spread to the cervical lymph nodes. Our aim was to investigate the influence of podoplanin expression on prognosis and metastatic lymphatic spread. In our retrospective study, podoplanin expression was examined in a set of 80 patients with OSCC by immunohistochemistry. We analysed associations between the level of podoplanin expression and various clinicopathologic parameters. In 67 patients (84%), podoplanin was expressed on the tumour cells. Nineteen patients (24%) showed high levels of expression. The 5-year overall survival (31%) for patients with high levels of podoplanin expression was significantly lower (p < 0.001) than for patients with low and moderate expression of podoplanin (93% and 65%, respectively). There was an association between podoplanin expression and the frequency of cervical lymph node metastases. Cervical lymph node metastases were found in 79% of the patients with high podoplanin expression, while patients with weak podoplanin expression had metastases in only 22% (p < 0.001). None of the 13 patients without podoplanin expression had cervical lymph node metastases. We concluded that podoplanin is expressed frequently in OSCC and that podoplanin expression correlates with cervical lymph node metastases and clinical outcome.

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“…But the reason why the outcomes of some tumors are so much worse than those of others has still not been discovered. One of the most important prognostic factors for lymph node metastasis in head and neck cancer is tumor infiltration depth[2], but the reason for different histological growth patterns and lymphogenic metastases is still unknown.…”

Section: Introductionmentioning

confidence: 99%

An evaluation of the preoperative hemoglobin level as a prognostic factor for oral squamous cell carcinoma

Cordella¹,

Luebbers²,

Rivelli³

et al. 2011

Head Neck Oncol

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BackgroundHypoxia seems to be an influencing factor for oral squamous cell carcinomas (SCC), and several immunohistochemical markers have been discussed in this regard. The aim of the present study was to evaluate preoperative hemoglobin levels as a prognostic factor for oral SCC.Materials and methodsThe files of 287 patients who had been treated for oral SCC between 1999 and 2008 were studied retrospectively. Hemoglobin levels between 1 and 5 days prior to surgical treatment were compared to Tumor (T)- and Nodal (N)- status, local recurrence, and lymph node metastases rate. The minimum follow-up period was 12 months.ResultsFrom a total of 287 patients with oral SCC, 205 (71.4%) were in the normal hemoglobin (Hb) group (female Hb≥12.0 g/dl; male Hb≥13.0 g/dl), 53 (18.5%) in the mild anemia (female Hb = 11.0-11.9 g/dl; male Hb = 11.0-12.9 g/dl), and 29 (10.1%) in the severe anemia group (female & male Hb<11.0 g/dl). Anemia was significant for the development of lymph node metastasis (p = 0.005) as well as for local recurrence (p = 0.001). No significant correlation was found to the initial T status (p = 0.183).ConclusionOur data suggests that an Hb of below 11 g/dl contributes to and is an indicator for a poor prognosis. Consequently, pre-treatment Hb corrections may significantly improve outcome, but further investigations, including blood transfusion/application of erythropoietin due to tumor anemia, independent of intraoperative blood-loss are necessary to ascertain their role in an improved survival.

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Determinants of Outcome Following Surgery for Oral Squamous Cell Carcinoma

Cited by 24 publications

References 113 publications

DNA methylation analysis of cancer-related genes in oral epithelial cells of healthy smokers

DNA methylation analysis of cancer-related genes in oral epithelial cells of healthy smokers

Impact of podoplanin expression in oral squamous cell carcinoma: clinical and histopathologic correlations

An evaluation of the preoperative hemoglobin level as a prognostic factor for oral squamous cell carcinoma

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