Determinants of Nocturnal Cardiovascular Variability and Heart Rate Arousal Response in Restless Legs Syndrome (RLS)/Periodic Limb Movements (PLMS)

Sforza, Émilia; Roche, Frédéric; Pichot, Vincent

doi:10.3390/jcm8101619

Cited by 13 publications

(3 citation statements)

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“…There are increasing evidence that vitamin D can regulate the circadian rhythm of sleep ( 41 , 42 ). Several magnetic resonance imaging (MRI) studies had revealed an increased glutamic acid in the thalamus of RLS patients, which also was associated with sleep quality ( 43 – 45 ), providing insight into the role of glutamate and dopamine in regulating sleep–wake disorder ( 46 ). The pathogenesis of the regulatory role of vitamin D in sleep disorder with RLS patients is largely unknown.…”

Section: Discussionmentioning

confidence: 99%

Correlation between vitamin D and poor sleep status in restless legs syndrome

et al. 2022

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BackgroundRestless Legs Syndrome (RLS) is closely related to poorer sleep quality. Vitamin D can regulate sleep regulation, cell proliferation, and differentiation. To measure whether vitamin D has predictive value for poor sleep quality in RLS was our aim in this study.MethodsTo analyze the serum levels of 25-hydroxyvitamin D [25(OH)D] in 95 RLS patients. We used the Pittsburgh Sleep Quality Index (PSQI) to measure sleep quality. Subjects had been divided into a normal and poor-sleeper groups according to the PSQI score. Using correlation and regression analysis to explore underlying etiologies that affect sleep disorder in RLS patients.ResultsPatients in the poor-sleeper group had significantly lower vitamin D levels in comparison to the normal group. The serum vitamin D levels were negative correlate with PSQI scores after adjusting for confounding factors. In addition, regression analysis showed that vitamin D could act as a predictor for sleep disorders in RLS patients (odds ratio [OR] = 0.008, p = 0.004). The area under the curve (AUC), cut-off value, sensitivity, and specificity of serum vitamin D was 0.967 (95% CI 0.935–0.998), 16.84 ng/ml, 87.5%, and 93.7% by receiver operating characteristic (ROC) analysis.ConclusionOur study confirmed the relationship between poorer sleep quality and vitamin D in RLS. However, the causal relationship between vitamin D deficiency and RLS is currently inconclusive. The effect of vitamin D supplementation is needed to confirm as the therapeutic strategies for sleep disorders in RLS patients in future work.

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Section: Discussionmentioning

confidence: 99%

Correlation between vitamin D and poor sleep status in restless legs syndrome

et al. 2022

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“…The repeated increase in nocturnal heart rate and blood pressure are considered to be the reason for the negative influence of PLMS on the cardiovascular system. Nevertheless, some researchers deny the existence of persistent sympathetic hyperactivity in the absence of movement (in other words, sympathetic hyperactivity exists only when PLMS occurs) ( 37 , 38 ). On the other hand, other authors highlighted the primary role of the sympathetic nervous system in the generation of PLMS ( 39 ).…”

Section: Introductionmentioning

confidence: 99%

Periodic Limb Movements Syndrome in Patients With Cerebral Small Vessel Disease: Protocol for a Prospective Observational Study

2021

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Background: Cerebrovascular diseases are the leading cause of cognitive decline and dementia. Therefore, the investigation of the potential ways to slow down the disease progression is an important research field. Periodic limb movements in sleep (PLMS) are known to be associated with transient changes in heart rate and blood pressure. These changes might influence the course of cerebral small vessel disease (cSVD). Nevertheless, the clinical significance of PLMS, particularly its influence on cardiovascular diseases course, is still controversial and underinvestigated.Methods/design: Patients from 60 to 75 years old diagnosed with cSVD will undergo nocturnal polysomnography. Subjects with apnea/hypopnea index under 5 will be enrolled. Sleep quality and daytime functioning will be assessed at baseline with self-reported questionnaires. Brain MRI and cognitive assessment will be performed at baseline and in the 2-year follow-up. Progression of cSVD markers and cognitive dysfunction will be compared between patients with PLMS index (PLMI) equal to or more than 15 movements per hour of sleep and controls (PLMI <15/h).Discussion: The negative role of PLMS in cSVD progression and related cognitive decline is expected. We suppose that patients with PLMS tend to worsen in cognitive performance more rapidly than age-, gender-, and comorbidity-matched controls. We also expect them to have more rapid white matter hyperintensities and other cSVD marker progression. The limitations of the study protocol are the short follow-up period, the absence of a treatment group, and inability to make a conclusion about causality.

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“…In fact, three papers explored the role of ANS in acute and chronic neurological disorders, such as Restless Legs Syndrome/Periodic Limb Movements, stroke, and multiple sclerosis. The study by Sforza and colleagues showed that a significant increase in sympathetic activity occurred in periods with periodic limb movements and electromyogram power is the factor that affects sympathetic control [ 5 ]. Lin et al observed that baroreflex sensitivity can predict functional outcomes and complications after acute ischemic stroke [ 6 ].…”

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confidence: 99%