Determinants of neonatal sepsis among neonates admitted in a neonatal intensive care unit at Jinka General Hospital, Southern Ethiopia

Ketema, Erkihun; Mamo, Mesfin; Miskir, Direslegn; Hussen, Sultan; Boti, Negussie

doi:10.5897/ijnm2018.0335

Cited by 13 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study revealed that the neonates who were born from the mothers who had a history of either STI/UTI during the index pregnancy were 9.44 times more likely to develop lateonset neonatal sepsis compared to those who had no history of either STI/UTI during the index pregnancy. The finding is similar to the studies conducted in Bishoftu, Debrezeyit-Ethiopia [18], Jinka, Southern Ethiopia [19] and study conducted in Mekelle, Northern Ethiopia [16]. This finding is also in line with the study conducted in India and Al-Nasiriayh city, Southern Iraq [20].…”

Section: Plos Onesupporting

confidence: 91%

“…Data were collected by using a Data extraction tool and interview. The tool was developed after reviewing different kinds of literature related to the title [16][17][18][19][20][21][22]. The data extraction tool has medical record number, socio-demographic characteristics of neonate and index mother and neonatal, maternal and breastfeeding health-related characteristics.…”

Section: Data Collection Tool and Proceduresmentioning

confidence: 99%

See 1 more Smart Citation

Determinants of late-onset neonatal sepsis among neonates admitted to the neonatal intensive care unit of Arba-Minch general hospital, southern Ethiopia

et al. 2022

View full text Add to dashboard Cite

Introduction Neonatal sepsis can be either early (<7 Days) or late-onset ≥7days) neonatal sepsis depending on the day of the occurrence. Despite the decrement in early onset neonatal sepsis, there is still an increment in late-onset neonatal sepsis. Ethiopian demography and health survey report showed an increment in neonatal mortality in 2019/20. Objective The objective of this study was to assess the determinants of late-onset neonatal sepsis among neonates admitted to the neonatal intensive care unit at Arba-Minch general hospital, southern Ethiopia. Methods An institution based study was conducted from March 1, 2021, to June 30, 2021 in Arba-Minch general hospital. Cases were neonates diagnosed with late-onset neonatal sepsis with their index mother chart and controls were neonates admitted with other diagnoses at the same period. Cases and controls were selected consecutively. Data extraction tool and interview which was developed by reviewing different kinds of literature was used to collect data. Data were entered by using Epi data version 3.1software and transformed to Statistical Package for Social Sciences version 25 software for analysis. The binary logistic regression model was used to assess determinants and variables with a p-value <0.2 were transformed to multivariable logistic regression then, a p-value < 0.05 with 95% confidence interval were used to declare significant association with the outcome variable. Result A total of 180 subjects (60 cases and 120 controls) were included in this study. The mean age of neonates was 12.1 days with standard deviations of 4.3. Multivariable logistic regression analysis showed that; history of either sexually transmitted disease /urinary tract infection [AOR = 9.4; 95%CI(3.1–28.5)], being preterm (gestational age of <37 weeks) [AOR = 4.9; 95%CI (1.7–13.7)], use of endotracheal intubation/mechanical intubation [AOR = 8.3; 95%CI (1.8–26.4)]and either mixed types of infant feeding option or formula feeding before admission [AOR = 12.7; 95%CI(3.7–42.8)]were significantly associated with late-onset neonatal sepsis. Conclusion and recommendations This study revealed that antenatal, intrapartum and postpartum factors have shown an association with late-onset neonatal sepsis. It is recommended to strengthen counseling and advice to mothers with specific risk factors of late-onset neonatal sepsis.

show abstract

Section: Plos Onesupporting

confidence: 91%

Section: Data Collection Tool and Proceduresmentioning

confidence: 99%

Determinants of late-onset neonatal sepsis among neonates admitted to the neonatal intensive care unit of Arba-Minch general hospital, southern Ethiopia

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Therefore, screening of pregnant women is essential to avoid the aforementioned complications through early diagnosis and treatment of urinary tract infection during pregnancy. In Ethiopia, variety of studies [49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75] revealed the prevalence of neonatal sepsis with great inconsistencies across different geographical regions ranging from 11.7% in Amhara region [62] to 77.9% in Oromia region [53]. This inconsistence necessitates nationally pooled evidence about the burden of neonatal sepsis.…”

Section: Records Identified Through Data Base Searching (N=1181)mentioning

confidence: 99%

“…Five of the overall 27 studies reported significance of antenatal urinary tract infection on neonatal sepsis. Besides, pooled effect sizes of these 5 different studies [51,54,64,67,68] showed that neonates delivered from mothers who experienced urinary tract infection during pregnancy were 3.55 times more likely to develop neonatal sepsis as compared to those neonates born to mothers who didn't experience antenatal urinary tract infection [AOR ¼ 3.55; 95% CI: 2.04, 5.06] [ Figure 9].…”

Section: The Effect Of Antenatal Urinary Tract Infection (Uti) On Thementioning

confidence: 99%

The burden of neonatal sepsis and its association with antenatal urinary tract infection and intra-partum fever among admitted neonates in Ethiopia: A systematic review and meta-analysis

Bayih

Ayalew

Chanie

et al. 2021

Heliyon

View full text Add to dashboard Cite

Background: More than one-third of the neonatal death in Ethiopia has been attributed to neonatal sepsis. However, there is no recent national evidence about the burden of neonatal sepsis and its association with antenatal urinary tract infection and intra-partum fever, which are commonly reported maternal morbidities in Ethiopia. Therefore, the aim of this systematic review and meta-analysis was to assess the pooled burden of neonatal sepsis and its association with antenatal urinary tract infection as well as intra-partum fever in the country. Methods: Primary studies were accessed through Google scholar, HINARI, SCOPUS and PubMed databases. The methodological and evidence quality of the included studies were critically appraised by the modified Newcastle-Ottawa quality assessment tool scale adapted for observational studies. From eligible studies, two authors extracted author/ year, study region, study design, sample size, reported prevalence of neonatal sepsis, antenatal urinary tract infection and intrapartum fever on an excel spreadsheet. During critical appraisal and data extraction, disagreements between the two authors were resolved by the involvement of a third author. The extracted data were then exported to stata version 14. Effect sizes were pooled using the random inverse varience-effects model due to significant heterogeneity between studies (I 2 ¼ 99.2%). Subgroup analysis was performed for evidence of heterogeneity. Sensitivity analyses were performed. Absence of publication bias was declared from symmetry of funnel plot and Egger's test (p ¼ 0.244). Results: In this systematic review and meta-analysis, a total of 36,016 admitted neonates were included from 27 studies. Of these 27 studies, 23 employed cross-sectional design whereas 3 studies had case control type and only one study had cohort design. The prevalence of neonatal sepsis among admitted Ethiopian neonates at different regions of the country ranged from 11.7%-77.9%. However, the pooled prevalence of neonatal sepsis was 40.25% [95% CI: 34.00%, 46.50%; I 2 ¼ 99.2%]. From regional subgroup analysis, the highest prevalence was observed in the Oromiya region. Neonates born to mothers who had antenatal urinary tract infection were at 3.55 times (95% CI: 2.04, 5.06) higher risk of developing neonatal sepsis as compared to those neonates born to mothers who didn't have antenatal urinary tract infection. Moreover, neonates born to mothers having intra-partum fever were 3.63 times (95% CI: 1.64, 5.62) more likely to develop neonatal sepsis as compared to those born to mothers who were nonfebrile during intrapartum. Conclusion: Neonatal sepsis has remained a problem of public health importance in Ethiopia. Both antenatal urinary tract infection and intra-partum fever were positively associated with neonatal sepsis. Therefore, preventing maternal urinary tract infection during pregnancy and optimizing the intra-partum care are recommended to mitigate the burden of neonatal sepsis in Ethiopia.

show abstract

“…In Sub-Saharan Africa, neonatal sepsis is responsible for 17% of neonatal mortality. Neonatal sepsis, which causes over 37% of newborn mortality in Ethiopia and more than one-third of all neonatal deaths, is to blame [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Treatment outcome of neonatal sepsis and associated factors among neonates admitted to neonatal intensive care unit in public hospitals, Addis Ababa, Ethiopia, 2021. Multi-center cross-sectional study

Endazanaw,

Mulugeta,

Abebe

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Background Globally, neonatal sepsis is the leading cause of neonatal mortality and morbidity, particularly in developing countries. Despite studies that revealed the prevalence of neonatal sepsis in developing countries, the outcome of the diseases, barriers for poor outcomes were inconclusive. The aim of this study was to assess the treatment outcome of neonatal sepsis and its associated factors among neonates admitted to neonatal intensive care unit in public hospitals, Addis Ababa, Ethiopia, 2021. Methods A cross-sectional study was carried out from February 15 to May 10, 2021 on 308 neonates admitted to neonatal intensive care units of Addis Ababa city public hospitals. Hospitals and study participants were selected by lottery and systematic random sampling techniques, respectively. Data were collected through face-to-face interviews with a structured, pretested questionnaire and by reviewing both the maternal and newborn profile cards. Epi-data version 4.6 was used to enter the collected data, which was then exported to SPSS version 26 for analysis. The 95% CI odds ratio is used to determine the direction and strength of the association between the dependent and independent variables. Results Among the total study 308 neonates, 75(24.4%) were died. Regarding the poor treatment outcome of neonatal sepsis, neonates whose mothers <37 weeks of gestational age (AOR = 4.87, 95% CI: 1.23–19.22), Grunting (AOR 6.94: 1.48–32.54), Meconium amniotic stained (AOR = 3.03, 95% CI: 1.02–9.01), Duration of rupture of membrane >18hours (AOR = 3.66, 95% CI: (1.20–11.15), Hypertensive PIH/ Eclampsia (AOR = 3.54, 95% CI: 1.24–10.09), Meropenum (AOR = 4.16, 95% CI: 1.22–14.21) and CRP positive result (AOR = 5.87, 95% CI: 1.53–22.56) were significantly associated with poor treatment outcome of neonatal sepsis. Conclusion and recommendation The treatment outcomes of neonates were 75.6% recovered and 24.4% died. In this setting, empirical treatment was the cornerstone for managing neonatal sepsis. Professionals who are working in labor and delivery ward screened for mothers preeclampsia and duration of rupture of membrane >18hrs /PROM/ treated with antihypertensive drug and antibiotics for the prevention of neonatal sepsis.

show abstract

Determinants of neonatal sepsis among neonates admitted in a neonatal intensive care unit at Jinka General Hospital, Southern Ethiopia

Cited by 13 publications

References 6 publications

Determinants of late-onset neonatal sepsis among neonates admitted to the neonatal intensive care unit of Arba-Minch general hospital, southern Ethiopia

Determinants of late-onset neonatal sepsis among neonates admitted to the neonatal intensive care unit of Arba-Minch general hospital, southern Ethiopia

The burden of neonatal sepsis and its association with antenatal urinary tract infection and intra-partum fever among admitted neonates in Ethiopia: A systematic review and meta-analysis

Treatment outcome of neonatal sepsis and associated factors among neonates admitted to neonatal intensive care unit in public hospitals, Addis Ababa, Ethiopia, 2021. Multi-center cross-sectional study

Contact Info

Product

Resources

About