Determinants of neonatal mortality at neonatal intensive care unit in Northeast Ethiopia: unmatched case-control study

Alemu, Abebaw Yeshambel; Belay, Getaneh Mulualem; Gobeza, Mengistu Berhanu; Birhane, Binyam Minuye

doi:10.1186/s41182-020-00232-9

Cited by 18 publications

(22 citation statements)

References 23 publications

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“… 31 , 35 – 37 Similarly, neonates born to a mother with premature rupture of membrane (PROM) were more likely to have NNM, a finding supported by previous studies. 10 , 16 , 19 Since association of PROM with preterm birth, respiratory distress syndrome, intravascular hemorrhage, cord prolapse, reduced amniotic fluid volume, chorioamnionitis, neonatal sepsis, and birth asphyxia was reported, 38 – 40 this finding was expected. Similarly, obstructed labor 14 , 16 , 19 and non-vertex presentation were associated with NNM.…”

Section: Discussionmentioning

confidence: 95%

Magnitude of neonatal near miss in public hospitals in Eastern Ethiopia: A cross-sectional study

et al. 2022

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Objectives: Although neonatal near miss is an emerging concept and a tool for improving neonatal care, its magnitude and associated factors are less researched in Ethiopia. Thus, this study was aimed to uncover the magnitude of neonatal near miss and its associated factors in public hospitals in Eastern Ethiopia. Methods: A facility-based cross-sectional study was employed on a randomly selected 405 mother–neonate pairs. An interview using a structured questionnaire accompanied by review of medical records was used to collect data from the mothers and records of the neonates. Neonatal near miss was defined as having any of the pragmatic (gestational age < 33 weeks, birth weight < 1750 g, and fifth minutes Apgar score < 7) or management criteria. Crude and adjusted logistic regression analysis was done to identify associated factors and presented with adjusted odds ratio with 95% confidence interval. Results: Of 401 mother–neonate pairs included in the study, 126 (31.4%, 95% confidence interval = [26.9, 36.2]) neonates had at least one neonatal near miss event at discharge. Neonatal near miss was more likely among neonates from referred women (adjusted odds ratio = 2.24, 95% confidence interval = [1.25, 4.03]), no antenatal care (adjusted odds ratio = 2.08, 95% confidence interval = [1.10, 3.93]), antepartum hemorrhage (adjusted odds ratio = 4.29, 95% confidence interval = [2.16, 8.53]), premature rupture of membrane (adjusted odds ratio = 4.07, 95% confidence interval = [2.05, 8.07]), obstructed labor (adjusted odds ratio = 2.61, 95% confidence interval = [1.23, 5.52]), non-vertex presentation (adjusted odds ratio = 3.03, 95% confidence interval = [1.54, 5.95]), and primiparous (adjusted odd ratio = 2.67, 95% confidence interval = [1.49, 4.77]). Conclusions: In this study, we found that neonatal near miss is higher than previous findings in Ethiopia. Improving neonatal near miss requires promoting antenatal care, maternal referral system, and early identification and management of obstetric complications.

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Section: Discussionmentioning

confidence: 95%

Magnitude of neonatal near miss in public hospitals in Eastern Ethiopia: A cross-sectional study

et al. 2022

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“…We included 12 cohort-studies, 21, 22, 24, 26, 28, 30, 31, 4748495051 10 cross-sectional, 19, 25, 27, 29, 32, 5253545556 and 5 case-control studies. 23, 57585960 The sample size of the studies is ranged from 228 to 14,188. In this systematic review and meta-analysis, 6 countries of the Eastern African region were represented (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Antenatal Care Predicts Neonatal Mortality in Eastern Africa: A Systematic Review and Meta-analysis of Observational Studies

Tiruye

Shiferaw

Shunu

et al. 2022

Journal of Neonatology

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Background Sub-Saharan African countries, especially the Eastern region, present the dismal picture of neonatal mortality (NM) in the globe. The majority of these deaths could be avoided if effective health measures are provided throughout pregnancy and childbirth. Although antenatal care (ANC) is assumed as one of the viable interventions that contribute to neonatal survival, the effect of ANC on NM was not systematically analyzed in Eastern Africa. Thus, the study aimed to determine the pooled effect of ANC on NM in Eastern Africa. Methods PubMed, EMBASE, CINAHL, and HINARI databases were searched using appropriate keywords from January 1, 1990 to February 12, 2021. Independent authors selected eligible articles and extracted data. The risk of a bias assessment tool for nonrandomized studies was used to assess the quality of the study. Comprehensive meta-analysis version 2 was used for meta-analysis. The random-effect model was employed, and the outcome is expressed as a risk ratio with 95% confidence interval (CI). Results In total, 1149 studies were identified through database search, and only 27 studies were included in the meta-analysis. Having at least 1 ANC visit during pregnancy reduced the risk of neonatal death by 42% compared to their counterparts (RR = 0.58, 95% CI [0.47, 0.71]). The pooled prevalence of NM was 8.5% (95% CI [7.3, 9.6]), with NM rate of 46.3/1000 live births. Conclusion The study indicated that NM might be decreased even with a single ANC visit when compared to no visits. Scaling up ANC services through ANC promotion and tackling service-related barriers could potentially reduce NM in Eastern Africa.

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“…Being born preterm increases risk of dying because of immature organs [6,7]. Hyaline membrane disease (HMD) is the leading cause of mortality and morbidity in preterm newborn babies [8][9][10][11][12], 45% of cause of death in Ethiopia [13], 46.9% in Nigeria [14], 12.8% in Poland [15]. In addition, the burden of NRDS among neonates reported as 52.9% of total admission in Egypt [16], 26.2% in Nigeria [14], 34.7% in Iraq [17], 57% in north India [18], 23.5% in nepal [19],11.9% in Jimma [20].…”

Section: Introductionmentioning

confidence: 99%

The burden of hyaline membrane disease, mortality and its determinant factors among preterm neonates admitted at Debre Tabor General Hospital, North Central Ethiopia: A retrospective follow up study

et al. 2021

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Background Hyaline membrane disease (HMD) is a leading cause of morbidity and mortality in preterm newborn babies. Though, there are studies related to Hyaline membrane disease inclusive of all neonates, studies related to the burden among preterm neonates were limited. In addition, increasing neonatal mortality in Ethiopia could be related to increase in the burden of hyaline membrane disease among preterm neonates. Therefore, this study was aimed to assess the burden of hyaline membrane disease, mortality and its associated factors among preterm neonate admitted at neonatal intensive care unit, North Central Ethiopia. Methodology An institution-based retrospective follow-up study was conducted among 535 preterm neonates admitted at neonatal intensive care unit from January 1, 2014-December 30, 2017. Data were entered into EPi-data 4.2.0.0 and transferred to STATA version 14 statistical software for statistical analysis. Binary logistic regression was used for the analysis. All variables with P-value < 0.25 during bi-variable analysis were considered for multivariable logistic regression. Level of statistical significance was declared at P value ≤0.05. Results In the current study, proportion of hyaline membrane disease was 40% (95% CI; 35.8, 44.3) of which 49.5% died. Preterm neonate born with Gestational age of less than 34 weeks of age (Adjusted odd ratio (AOR = 2.64; 95 CI: 1.49, 4.66)), 5th minute Apgar score less than 7 (AOR = 2.2; 95% CI: 1.20, 4.07), and newborn with birth weight of less than 1500 gram (AOR = 2.4, 95% CI: 1.3, 4.3) were predictors of hyaline membrane disease. Conclusions The mean gestational age (±) was 33.46 (±2.55) weeks. The incidence of hyaline membrane disease among preterm admissions was high. Preterm neonate born with gestational age of less than 34 weeks of age, asphyxiated newborns and newborn with birth weight of less than 1500 gram were predictors of hyaline membrane disease. So, emphasis should be given on early screening, follow up and timely interventions for preterm neonate.

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Determinants of neonatal mortality at neonatal intensive care unit in Northeast Ethiopia: unmatched case-control study

Cited by 18 publications

References 23 publications

Magnitude of neonatal near miss in public hospitals in Eastern Ethiopia: A cross-sectional study

Magnitude of neonatal near miss in public hospitals in Eastern Ethiopia: A cross-sectional study

Antenatal Care Predicts Neonatal Mortality in Eastern Africa: A Systematic Review and Meta-analysis of Observational Studies

The burden of hyaline membrane disease, mortality and its determinant factors among preterm neonates admitted at Debre Tabor General Hospital, North Central Ethiopia: A retrospective follow up study

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