2022
DOI: 10.1101/2022.12.23.521820
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Determinants of Motor Neuron Functional Subtypes Important for Locomotor Speed

Abstract: Locomotion requires precise control of the strength and speed of muscle contraction and is achieved by recruiting functionally-distinct subtypes of motor neurons (MNs). MNs are essential to movement and differentially susceptible in disease, but little is known about how MNs acquire functional subtype-specific molecular features during development. Using single cell RNA profiling in larval zebrafish, we identify novel and conserved molecular signatures for MN functional subtypes, and identify genes expressed i… Show more

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