Determinants of Morbidity and Mortality of Systemic Sclerosis in Canada

Al-Dhaher, Firas F.; Pope, Janet; Ouimet, Janine

doi:10.1016/j.semarthrit.2008.06.002

Cited by 192 publications

(126 citation statements)

References 47 publications

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“…There are 2 subtypes of SSc, i.e., diffuse cutaneous SSc (dcSSc) and limited cutaneous SSc (lcSSc), according to the extent of cutaneous involvement (2); dcSSc has more extensive skin involvement, including the trunk or proximal extremities, and is associated with more internal organ involvement such as significant interstitial lung disease (ILD), cardiomyopathy, and scleroderma renal crisis (SRC) and with increased mortality (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Association of C‐reactive protein with high disease activity in systemic sclerosis: Results from the Canadian Scleroderma Research Group

Muangchan¹,

Harding²,

Khimdas³

et al. 2012

Arthritis Care & Research

101

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Section: Introductionmentioning

confidence: 99%

Association of C‐reactive protein with high disease activity in systemic sclerosis: Results from the Canadian Scleroderma Research Group

Muangchan¹,

Harding²,

Khimdas³

et al. 2012

Arthritis Care & Research

101

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“…L'eziologia della SSc è sconosciuta e, nonostante i recenti progressi nella comprensione dei meccanismi patogenetici che ne sono alla base (2), la prevenzione ed il trattamento delle complicanze d'organo rappresentano ancora oggi una sfida per il clinico reumatologo, con conseguente impatto sulla qualità di vita e la sopravvivenza dei pazienti (3). Gli studi epidemiologici relativi agli ultimi decenni hanno registrato, in realtà, un miglioramento della sopravvivenza dei pazienti di SSc, sia a breve che a lungo termine, ed un cambiamento nelle principali cause di morte, sebbene con differenze legate all'area geografica di provenienza dei pazienti (4)(5)(6)(7)(8)(9)(10)(11)(12). Tra questi, uno studio italiano multicentrico, pubblicato nel 2002, ha riportato la sopravvivenza a breve, medio e lungo termine (5, 10 e 20 anni), e Reumatismo, 2010;62(3) (4).…”

Section: Introduzioneunclassified

Survival and death causes in 251 systemic sclerosis patients from a single Italian center

Vettori¹,

Cuomo²,

Abignano³

et al. 2011

Reumatismo

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INTRODUZIONEL a sclerosi sistemica (SSc) è una malattia acquisita del tessuto connettivo caratterizzata da una tipica vasculopatia del microcircolo, attivazione del sistema immunitario e fibrosi della cute e degli organi interni (cuore, polmoni, reni, apparato gastrointestinale, muscoli, articolazioni, tendini) (1). L'eziologia della SSc è sconosciuta e, nonostante i recenti progressi nella comprensione dei meccanismi patogenetici che ne sono alla base (2), la prevenzione ed il trattamento delle complicanze d'organo rappresentano ancora oggi una sfida per il clinico reumatologo, con conseguente impatto sulla qualità di vita e la sopravvivenza dei pazienti (3). Gli studi epidemiologici relativi agli ultimi decenni hanno registrato, in realtà, un miglioramento della sopravvivenza dei pazienti di SSc, sia a breve che a lungo termine, ed un cambiamento nelle principali cause di morte, sebbene con differenze legate all'area geografica di provenienza dei pazienti (4-12). Tra questi, uno studio italiano multicentrico, pubblicato nel 2002, ha riportato la sopravvivenza a breve, medio e lungo termine (5, 10 e 20 anni), e Reumatismo, 2010; 62(3):202-209

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“…Lung involvement and sclerodermal renal crisis were found to be independently associated with reduced survival [15]. Cardiac involvement, diffuse cutaneous SSc, and hypertension are associated with worse survival [16]. Other studies have confirmed the presence of diffuse cutaneous forms and renal involvement as independent risk factors for SSc-related mortality [17].…”

Section: Survival In Sscmentioning

confidence: 96%

Incidence and prevalence of Systemic Sclerosis (SSc) in Poland – differences between rural and urban regions

Kanecki

Goryński

Tarka

et al. 2017

Ann Agric Environ Med.

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Kanecki K, Goryński P,Tarka P, WierzbaW, Tyszko P. Incidence and prevalence of Systemic Sclerosis (SSc) in Poland -differences between rural and urban regions. Ann Agric Environ Med. 2017; 24(2): 240-244. doi: 10.5604/12321966.1233570 Abstract Introduction. Systemic sclerosis (SSc) is a rare and potentially severe connective tissue disease, characterized by skin fibrosis and involvement of internal organs. Because of its rarity and heterogeneous clinical presentation, reliable epidemiological studies on SSc have been particularly difficult to carry out. Objectives. The purpose of this study was to present SSc epidemiology among hospitalized patients in Poland. Materials and method. The analysis was based on population-based administrative data, taken from a Polish hospital morbidity study carried out by the National Institute of Public Health between January 2008 -December 2012. Results. Analyzed data covered 9,049 hospitalization records. The final sample comprised 3,653 patients with first-time hospitalizations for SSc. The average age of the sample was 53 years (SD 16.2; range 0-91 years); 84% of patients were female and 16% male. Based on hospitalization registers, the average SSc incidence was estimated to be 1.9/100,000 per year and peak age of incidence was 55 years. The point prevalence was estimated to be 9.4/100,000 at the end of 2012. SSc was more common in females, with F:M ratio ranging from 6.2:1-4.6:1 depending on the year. Analysis of hospitalization trends revealed that overall numbers of SSc hospitalizations increased, while first-time hospitalizations decreased between 2008-2012. Clusters of higher incidence were observed in more rural regions vs. urban regions. Conclusion. Estimated incidence of SSc in Poland was comparable to reported incidence in other European countries. Analysis of demographic factors and reports of clusters of higher incidence may suggest the existence of environmental risk factors for the development of SSc. These observations may require further research.

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Determinants of Morbidity and Mortality of Systemic Sclerosis in Canada

Cited by 192 publications

References 47 publications

Association of C‐reactive protein with high disease activity in systemic sclerosis: Results from the Canadian Scleroderma Research Group

Association of C‐reactive protein with high disease activity in systemic sclerosis: Results from the Canadian Scleroderma Research Group

Survival and death causes in 251 systemic sclerosis patients from a single Italian center

Incidence and prevalence of Systemic Sclerosis (SSc) in Poland – differences between rural and urban regions

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