Determinants of microbial colonization in the premature gut

Chen, Xiaoyu; Shi, Yongyan

doi:10.1186/s10020-023-00689-4

Cited by 4 publications

(3 citation statements)

References 176 publications

(234 reference statements)

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“…During a vaginal birth, neonates traverse the birth canal, encountering a diverse array of maternal microorganisms that confer an early inoculation of the infant's gut [58][59][60].…”

Section: Mechanisms Involvedmentioning

confidence: 99%

The Impact of Cesarean Section Delivery on Intestinal Microbiota: Mechanisms, Consequences, and Perspectives—A Systematic Review

Inchingolo,

Palumbo

et al. 2024

IJMS

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The relationship between cesarean section (CS) delivery and intestinal microbiota is increasingly studied. CS-born infants display distinct gut microbial compositions due to the absence of maternal birth canal microorganisms. These alterations potentially link to long-term health implications like immune-related disorders and allergies. This correlation underscores the intricate connection between birth mode and the establishment of diverse intestinal microbiota. A systematic literature review was conducted on the PubMed, Scopus, and Web of Science databases by analyzing the articles and examining the intricate interactions between CS delivery and the infant’s intestinal microbiota. The analysis, based on a wide-ranging selection of studies, elucidates the multifaceted dynamics involved in CS-associated shifts in the establishment of fetal microbiota. We also explore the potential ramifications of these microbial changes on neonatal health and development, providing a comprehensive overview for clinicians and researchers. By synthesizing current findings, this review contributes to a deeper understanding of the interplay between delivery mode and early microbial colonization, paving the way for informed clinical decisions and future investigations in the field of perinatal medicine.

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“…During a vaginal birth, neonates traverse the birth canal, encountering a diverse array of maternal microorganisms that confer an early inoculation of the infant's gut [58][59][60].…”

Section: Mechanisms Involvedmentioning

confidence: 99%

The Impact of Cesarean Section Delivery on Intestinal Microbiota: Mechanisms, Consequences, and Perspectives—A Systematic Review

Inchingolo,

Palumbo

et al. 2024

IJMS

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“…Nuntnarumit et al reported [ 14 ] that CRP is indicative for the diagnosis of EOS, leading to prolonged antibiotic use in neonatal intensive care units (NICUs) usually due to high CRP status. This inevitably leads to overuse of antibiotics, resulting in the development and spread of antibiotic resistance [ 15 ] and other adverse outcomes such as neonatal necrotizing enterocolitis (NEC) and late-onset sepsis (LOS) [ 16 ]. And excessive antibiotic therapy increases the risk of abnormal bacterial colonization, increase in resistant bacteria, and allergic manifestations [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…This inevitably leads to overuse of antibiotics, resulting in the development and spread of antibiotic resistance [ 15 ] and other adverse outcomes such as neonatal necrotizing enterocolitis (NEC) and late-onset sepsis (LOS) [ 16 ]. And excessive antibiotic therapy increases the risk of abnormal bacterial colonization, increase in resistant bacteria, and allergic manifestations [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Factors influencing C-reactive protein status on admission in neonates after birth

Cao,

Wang,

Liu

et al. 2024

BMC Pediatr

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Objective To explore the factors influencing C-reactive protein (CRP) status in neonates on admission after birth. Methods 820 newborns born and hospitalized at Xiangya Hospital of Central South University from Jan. 2020 to Dec. 2020 were retrospectively analyzed. Maternal medical history and medication use during pregnancy, neonatal demographic information and status at birth were collected through the electronic medical record system. Statistical software was used to analyze the possible relationship between perinatal factors and CRP on admission after birth. Results A total of 820 neonates were analyzed, including 463 males and 357 females with a mean gestational age (GA) of 36.07 ± 3.30 weeks. (1) Multifactor Logistic regression analysis: larger GA (OR: 1.13, 95%CI: 1.00-1.28, P = 0.042), premature rupture of membranes (PROM) ≥ 18 h (OR: 2.39, 95%CI: 1.35–4.23, P = 0.003) and maternal autoimmune diseases (OR: 5.30, 95%CI: 2.15–13.07, P < 0.001) were independent risk factors for CRP ≥ 8 mg/L. Cesarean delivery (OR 0.40, 95%CI: 0.26–0.60, P < 0.001) was independent protective factor for CRP ≥ 8 mg/L. (2) Threshold effect analysis: A non-linear relationship was found between GA and CRP. When GA is less than 33.9 weeks, the risk of CRP ≥ 8 mg/L was reduced by 28% with one week increased (P < 0.001), and when GA is more than 33.9 weeks, the risk of CRP ≥ 8 mg/L was increased by 61% with one week increased (P < 0.001). Conclusions GA, PROM, maternal autoimmune diseases and cesarean delivery were all independent influences neonatal CRP ≥ 8 mg/L on admission, and there was a nonlinear relationship between GA and neonatal CRP ≥ 8 mg/L on admission.

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Microbiote intestinal : de la stérilité chez les nouveau-nés à la complexité des interactions chez l’adulte

Comtet-Marre,

Chakoory,

Rochette

et al. 2024

Cahiers de Nutrition et de Diététique

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Determinants of microbial colonization in the premature gut

Cited by 4 publications

References 176 publications

The Impact of Cesarean Section Delivery on Intestinal Microbiota: Mechanisms, Consequences, and Perspectives—A Systematic Review

The Impact of Cesarean Section Delivery on Intestinal Microbiota: Mechanisms, Consequences, and Perspectives—A Systematic Review

Factors influencing C-reactive protein status on admission in neonates after birth

Microbiote intestinal : de la stérilité chez les nouveau-nés à la complexité des interactions chez l’adulte

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