Determinants of methicillin-resistant Staphylococcus aureus (MRSA) prevalence in the Asia-Pacific region: A systematic review and meta-analysis

Lim, Wey Wen; Wu, Peng; Bond, Helen S.; Wong, Jessica Y.; Ni, Kaiwen; Seto, W. H.; Jit, Mark; Cowling, Benjamin J.

doi:10.1016/j.jgar.2018.08.014

Cited by 39 publications

(27 citation statements)

References 64 publications

(48 reference statements)

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“…The World Bank collates information on 10,000+ standardized metrics across all world countries over time ( 6 ). Various previous works showed significant correlations between AMR prevalence and socioeconomic factors for a large number of countries, including LMICs (19 to 103 countries per study) ( 7 – 15 ). Examples of socioeconomic determinants of AMR prevalence are the income status of individual countries ( 8 ), the extent of their out-of-pocket health expenditure ( 7 ), and poor governance and corruption ( 11 ).…”

mentioning

confidence: 92%

Filling the gaps in the global prevalence map of clinical antimicrobial resistance

Oldenkamp

Schultsz

Mancini

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

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Surveillance is critical in containing globally increasing antimicrobial resistance (AMR). Affordable methodologies to prioritize AMR surveillance efforts are urgently needed, especially in low- and middle-income countries (LMICs), where resources are limited. While socioeconomic characteristics correlate with clinical AMR prevalence, this correlation has not yet been used to estimate AMR prevalence in countries lacking surveillance. We captured the statistical relationship between AMR prevalence and socioeconomic characteristics in a suite of beta-binomial principal component regression models for nine pathogens resistant to 19 (classes of) antibiotics. Prevalence data from ResistanceMap were combined with socioeconomic profiles constructed from 5,595 World Bank indicators. Cross-validated models were used to estimate clinical AMR prevalence and temporal trends for countries lacking data. Our approach provides robust estimates of clinical AMR prevalence in LMICs for most priority pathogens (cross-validated q2 > 0.78 for six out of nine pathogens). By supplementing surveillance data, 87% of all countries worldwide, which represent 99% of the global population, are now informed. Depending on priority pathogen, our estimates benefit 2.1 to 4.9 billion people living in countries with currently insufficient diagnostic capacity. By estimating AMR prevalence worldwide, our approach allows for a data-driven prioritization of surveillance efforts. For carbapenem-resistant Acinetobacter baumannii and third-generation cephalosporin-resistant Escherichia coli, specific countries of interest are located in the Middle East, based on the magnitude of estimates; sub-Saharan Africa, based on the relative prevalence increase over 1998 to 2017; and the Pacific Islands, based on improving overall model coverage and performance.

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mentioning

confidence: 92%

Filling the gaps in the global prevalence map of clinical antimicrobial resistance

Oldenkamp

Schultsz

Mancini

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

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“…Within Asia, MRSA infections have been prevalent, reaching a peak in the late 1900s and thereafter remaining at a plateau amid the 2000s with an estimation of about 70% of hospitalacquired (HA) S. aureus infections between 2004-2006(Chen and Huang, 2014, Song et al, 2011. Due to the high population and resource limitations, there is a high risk of the spread of infectious diseases in Asia including MRSA infection (Lim et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Methicillin-resistant Staphylococcus aureus in Nepal: A systematic review and meta-analysis

Khanal

Sulochan

Gaire

et al. 2021

International Journal of Infectious Diseases

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…In another study, conducted in 26 public hospitals in Hong Kong between January 2010 and December 2012, an increasing rate of MRSA was reported 38. In a recent meta-analysis report from Asia Pacific regions, the proportion of MRSA among all tested samples was reported to be up to 39% and the proportion of MRSA among all S. aureus isolates was reported to be up to 89% 39. Multi-drug-resistant S. aureus, including MRSA, can easily spread from the hospital setting to the community and within the community and poses additional problems for infection control strategies 40.…”

Section: Introductionmentioning

confidence: 97%

<p>Recent advances in <em>Staphylococcus aureus</em> infection: focus on vaccine development</p>

Ansari

Jha

Mishra

et al. 2019

IDR

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Staphylococcus aureus normally colonizes the nasal cavity and pharynx. After breaching the normal habitat, the organism is able to cause a number of infections at any site of the body. The development of antibiotic resistance has created a global challenge for treating infections. Therefore, protection by vaccines may provide valuable measures. Currently, several vaccine candidates have been prepared which are either in preclinical phase or in early clinical phase, whereas several candidates have failed to show a protective efficacy in human subjects. Approaches have also been made in the development of monoclonal or polyclonal antibodies for passive immunization to protect from S. aureus infections. Therefore, in this review we have summarized the findings of recently published scientific literature to make a concise report.

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Determinants of methicillin-resistant Staphylococcus aureus (MRSA) prevalence in the Asia-Pacific region: A systematic review and meta-analysis

Cited by 39 publications

References 64 publications

Filling the gaps in the global prevalence map of clinical antimicrobial resistance

Filling the gaps in the global prevalence map of clinical antimicrobial resistance

Methicillin-resistant Staphylococcus aureus in Nepal: A systematic review and meta-analysis

<p>Recent advances in <em>Staphylococcus aureus</em> infection: focus on vaccine development</p>

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