Determinants of Long-Term Outcome after Radioiodine Therapy for Solitary Autonomous Thyroid Nodules

Bolusani, Hemanth; Okosieme, Onyebuchi; Velagapudi, Madhav; Parsons, Katherine E.; Lazarus, John H.

doi:10.4158/ep.14.5.543

Cited by 14 publications

(22 citation statements)

References 16 publications

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“…There are several possible explanations for and factors contributing to the higher incidence rate of hypothyroidism in our patients: First, the higher rate might be due to the longer follow‐up time in our study. When observation is limited to 12 months or less, as in several previous reports, 17,20,27 the overall hypothyroidism incidence rate of hypothyroidism may be lowered, as it increases with ongoing follow‐up time 15,19,21,25 . Second, pretreatment with antithyroid drugs is a possible confounder, because in case of stimulation of a previously suppressed TSH by antithyroid drugs, the risk of hypothyroidism may increase.…”

Section: Discussionmentioning

confidence: 95%

“…However, several limitations such as the heterogeneity of the studies included, the different formulas used for the estimation and calculation of the activity to apply, the different causes of hyperthyroidism and restriction of the follow‐up period to 12 months prevented a definitive conclusion being reached regarding the optimal dose regimen 14 . Other studies applied standard activities so that no preliminary radioiodine test was performed for the estimation of maximal uptake and half‐life 20,25 . In contrast, the results presented here have the major advantage of being the outcome of strict adherence to the prescribed radioiodine testing and peritherapeutic dosimetry protocol, including volumetric measurement by ultrasound, individual thyroidal radioiodine uptake and half‐life.…”

Section: Discussionmentioning

confidence: 98%

“…In a further analysis of 105 patients treated with radioiodine, Bolusani et al. 25 reported hypothyroidism to be a common outcome with an incidence of 33% at 5 years and 49% at 10 years after follow‐up. Comparing different fixed activities and calculated dose regimens in patients with hyperthyroidism, Zakavi et al.…”

Section: Discussionmentioning

confidence: 99%

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Development of hypothyroidism during long‐term follow‐up of patients with toxic nodular goitre after radioiodine therapy

Kahraman¹,

Keller

Schneider³

et al. 2012

Clinical Endocrinology

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Radioiodine treatment with a calculated dose regimen is a highly effective treatment option in patients with toxic goitre with an overall success rate of 98%. However, radioiodine treatment with an intended thyroid dose of 150 Gy leads to a high incidence of hypothyroidism on long-term follow-up. This finding supports the suggestion that in future intended thyroid doses could be lowered in patients treated with a calculated dose regimen for toxic nodular goitre.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 98%

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Development of hypothyroidism during long‐term follow‐up of patients with toxic nodular goitre after radioiodine therapy

Kahraman¹,

Keller

Schneider³

et al. 2012

Clinical Endocrinology

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“…Group A patients had lower serum FT3 ( ~ 0.6 pmol / L or 9 % ) and FT4 ( ~ 0.9 pmol / L or 4 % ) as compared to group B. It has been reported that positiveness for thyroid autoantibodies represents a signifi cant risk factor for the development of hypothyroidism after radioiodine treatment of nodular toxic goiter ( Mariotti et al, 1986 ;Bolusani et al, 2008 ). A positive correlation between nodule size and age was found only in group B ( P = 0.015).…”

Section: Introduction ▼mentioning

confidence: 99%

“…Conclusion: Even if diff erence in the size of nodules between groups A and B does not reach statistical signifi cance, the chronic intrathyroid lymphocytic infi ltration of HT may decrease the tendency of the AFTNs to grow and diminish their degree of functioning. Such a study would also be of interest for therapeutic implications, because of the above mentioned risk of post-radioiodine hypothyroidism ( Mariotti et al, 1986 ;Bolusani et al, 2008 ). the authors ( Bialas et al, 1976 ;Sulimani and el-Desouki, 1990 ; Hoogenberg and van Tol, 2001 ;Boi et al, 2002 ;Mousavi et al, 2002 ;Boughattas et al, 2003 ;Zengi et al, 2009 ) warn that the " hot " nodule is just thyroid tissue spared by lymphocytic infi ltration, not a truly AFTN.…”

Section: Introduction ▼mentioning

confidence: 99%

Determining the Waist Circumference Cut off which Best Predicts the Metabolic Syndrome components in urban Africans: The SABPA study

Prinsloo¹,

Malan²,

Ridder³

et al. 2011

Exp Clin Endocrinol Diabetes

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Various studies have shown that the relationship between waist circumference (WC) and abdominal obesity is age, gender as well as ethnicity-dependent. WC criteria for Sub Saharan Africans have not been defined by the International Diabetes Federation (IDF). The aim was to determine which WC cut off best predicted Metabolic Syndrome (MetS) in a group of urban African teachers (80 males and 93 females). We determined sphygmomanometer blood pressure, WC, glucose, high density lipoprotein cholesterol (HdL) and triglyceride (TRIG) values. The males' MetS profile was less favourable as their glucose, TRIG and blood pressure levels were higher than the proposed cut off for MetS. The females could be classified as obese, based on their mean BMI (32.78±6.36) and WC (93.48±15.68). Receiver operating characteristic (ROC) WC cut offs of 90, 91, 94 and 96 cm for the respective MetS components in males (blood pressure, HdL, glucose and TRIG) were suggested. In the females, cut offs of 92, 98, 94 and 94 cm for TRIG, blood pressure, HdL and glucose respectively, were put forward. Odds ratios revealed that increased blood pressure best predicted ROC WC in both males (OR 9.59; 95% CI 3.14-29.32) and females (OR 3.11; 95% CI 1.30-7.42) irrespective of age. We suggest that the optimal cut off point for the males be set at 90 cm, as opposed to the current 94 cm; whilst the female cut off be set at 98 cm as opposed to the existing cut off of 80 cm. Larger sample groups are recommended to justify our data.

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Single‐Fiber Laser Ablation in Treating Selected Metastatic Lymph Nodes of Papillary Thyroid Carcinoma and Benign Cold Thyroid Nodules—Preliminary Results

Guo

Wang

et al. 2019

Lasers Surg Med

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Background and Objectives To evaluate the feasibility and efficacy of single‐fiber laser ablation (LA) under ultrasound guidance and appropriate ablation modes in the treatment of selected metastatic lymph nodes of papillary thyroid carcinoma (PTC) and benign cold thyroid nodules Study Design/Materials and Methods A total of 18 patients (consisting of 8 patients with 18 metastatic lymph nodes of PTC and 10 patients with 10 benign cold thyroid nodules) each underwent one session of single‐fiber LA under ultrasound guidance. On the basis of the sizes of the nodules, the ablation modes were chosen accordingly. The single‐dot ablation mode was used in the nodules with three orthogonal diameters measuring no greater than 10 mm in diameter, with a dot, a level and an insertion. The double‐dots overlapping ablation mode was used in the nodules with the largest diameters measuring greater than 10 mm (in which the nodules measured no more than 15 mm in diameter and with the other two perpendicular diameters measuring no greater than 10 mm in diameter) with two dots, a level and two insertions. The multiple levels and dots overlapping ablation mode was used in the nodules with the three orthogonal diameters all measuring larger than 10 mm, with multiple dots, levels and insertions. Results After 12 months of follow‐up in the treated nodules of the metastatic lymph nodes of PTC and benign cold thyroid nodules, the mean baseline volumes decreased from 0.29 ± 0.12 to 0.03 ± 0.03 ml and 3.85 ± 0.64 to 1.1 ± 0.37 ml, respectively, and the mean volume reduction ratios (VRRs), which was calculated as {[(initial volume−final volume) × 100%]/initial volume}, were 90.3 ± 7.6% and 72 ± 5.8%, respectively. There were six ablative zones that completely disappeared, whereas the ablative zones that still existed presented as scar‐like areas or small hyperechoic areas that were compatible with scar tissue among the 18 malignant nodules at the last follow‐up. Conclusions Single‐fiber LA under ultrasound guidance, with the appropriate ablation modes, is feasible and effective for the treatment of selected metastatic lymph nodes of PTC and benign cold thyroid nodules. This study suggests that single‐fiber LA may be applied to selected cases with appropriate ablation modes. Lasers Surg. Med. 2019 © 2019 Wiley Periodicals, Inc.

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Determinants of Long-Term Outcome after Radioiodine Therapy for Solitary Autonomous Thyroid Nodules

Cited by 14 publications

References 16 publications

Development of hypothyroidism during long‐term follow‐up of patients with toxic nodular goitre after radioiodine therapy

Development of hypothyroidism during long‐term follow‐up of patients with toxic nodular goitre after radioiodine therapy

Determining the Waist Circumference Cut off which Best Predicts the Metabolic Syndrome components in urban Africans: The SABPA study

Single‐Fiber Laser Ablation in Treating Selected Metastatic Lymph Nodes of Papillary Thyroid Carcinoma and Benign Cold Thyroid Nodules—Preliminary Results

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