Determinants of long-term health-related quality of life in adult patients with mild traumatic brain injury

Yousefzadeh-Chabok, Shahrokh; Kapourchali, Fatemeh Ramezani; Ramezani, Sara

doi:10.1007/s00068-019-01252-9

Cited by 16 publications

(10 citation statements)

References 33 publications

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“…Since this is the first study to explore the correlation between cognition and QoL in high-dose BZD/Z-drug users, our finding is difficult to compare to previous reports, being the effect on SF-36 scores also related to the underlying disease and the age class. Indeed, similar findings were reported in a sample of patients with mild traumatic brain injury with a similar age than ours (Yousefzadeh-Chabok et al 2019).…”

Section: The Influence Of Adult Adhd and Cognition On Qolsupporting

confidence: 91%

Adult attention-deficit/hyperactivity disorder symptoms, cognitive dysfunction and quality of life in high-dose use of benzodiazepine and Z-drug

et al. 2020

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High-dose use of benzodiazepines (BZDs) and Z-drugs was found to be associated with adult attention deficit/hyperactivity disorder (ADHD) and multidomain cognitive deficits, but the interplay between these factors and its effect on quality of life (QoL) is unclear. We explored (a) whether cognitive dysfunction differs in high-dose BZD/Z-drug users with and without adult ADHD and (b) the impact of cognitive deficits and adult ADHD on QoL in this substance-use disorder (SUD). From January 2015 to December 2019, we recruited 207 high-dose BZD/Z-drug users seeking treatment. We assessed the presence of adult ADHD with a screening tool, which was validated in SUD patients, and collected demographic, clinical and QoL data from the 76 included patients. A neuropsychological battery explored five cognitive domains. We found that: (a) screening for adult ADHD was frequently positive; (b) Short Form-36 (SF-36), a self-administered QoL questionnaire, was worse than the general population and worse in patients positive (ADHD+) vs. those negative (ADHD−) to ADHD screening tool; (c) executive function was significantly worse in ADHD+ than ADHD− patients; (d) some SF-36 dimensions were negatively influenced by executive dysfunction; (e) multivariate analysis showed an interplay between adult ADHD and cognitive dysfunction in worsening QoL. We documented a complex interplay between adult ADHD, cognitive dysfunction and QoL in high-dose BZD/Z-drug users. Assessing adult ADHD, neuropsychological measures and QoL may offer a full scenario of these patients, who are frequently impaired in everyday activities. Future research should explore whether pharmacological treatment might improve cognitive dysfunction and QoL in this SUD.

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Section: The Influence Of Adult Adhd and Cognition On Qolsupporting

confidence: 91%

Adult attention-deficit/hyperactivity disorder symptoms, cognitive dysfunction and quality of life in high-dose use of benzodiazepine and Z-drug

et al. 2020

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“…This differs from the findings of a study by Yousefzadeh-Chabok and colleagues, which found women and those of younger age 18–35 had significantly lower HRQOL scores 6 months post-concussion. 44 This study used a different measure of HRQOL, the Short Form-36, and it is possible that the difference in findings is due to different measurement tools. Additionally, this sample was recruited from patients who were admitted to hospital in Iran for their initial concussion, 44 in comparison to referral to a specialized outpatient concussion clinic in our study.…”

Section: Discussionmentioning

confidence: 99%

“…44 This study used a different measure of HRQOL, the Short Form-36, and it is possible that the difference in findings is due to different measurement tools. Additionally, this sample was recruited from patients who were admitted to hospital in Iran for their initial concussion, 44 in comparison to referral to a specialized outpatient concussion clinic in our study. Finally, Yousefzadeh-Chabok and colleagues’ data were collected at 6 months post-injury compared to our study in which the average participant was greater than 1-year post-injury, thus reflecting a more chronic condition that may not be influenced by age and sex.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Quality of Life in Adults with Persistent Post-Concussion Symptoms

Popov

Mercier

King

et al. 2021

Can. J. Neurol. Sci.

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Objective: To assess demographic, clinical, and injury characteristics associated with health-related quality of life (HRQOL) in adults with persistent post-concussion symptoms (PPCS). Methods: Adults with PPCS presenting to a specialized brain injury clinic completed demographic, injury, and clinical outcome questionnaires at the initial clinic assessment. Clinical outcome measures were collected including the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder Scale-7 (GAD-7), and the Fatigue Severity Scale (FSS). HRQOL was measured using the Quality of Life after Brain Injury (QOLIBRI) questionnaire. Stepwise hierarchical multiple regression analysis adjusting for age, sex, and months since injury was used to determine associations between quality of life and clinical outcome measures. Results: Overall, 125 participants were included. The PHQ-9, FSS, and GAD-7 were significant predictors of QOLIBRI scores (R2 = 0.481, p < .001), indicating that participants with higher levels of depressive symptoms, fatigue, and anxiety reported poorer HRQOL. The PHQ-9 score was the strongest predictor, accounting for 42.0% of the variance in QOLIBRI scores. No demographic or injury characteristics significantly predicted QOLIBRI scores. There was a high prevalence of depressive symptoms with 72.8% of participants having PHQ-9 scores ≥ 10. Conclusion: Among patients with PPCS, mental health and fatigue are important contributors to HRQOL. As there is a high burden of mood disorders and fatigue in this population, targeted treatments for these concerns may impact the quality of life.

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“…On the other hand, when parental supervision is reduced, as, in the case of students in the present study, the use of student restraint is less. However, in the north of Iran, with such a high rate of motor vehicle accidents [ 29 ], we had one of the lowest rates of use of seatbelts among students. Therefore, the need for parental education is palpable.…”

Section: Discussionmentioning

confidence: 99%

A study of students’ use of restraint systems in school transportation services in primary and secondary schools in northern Iran: an observational study

Yousefzade-Chabok

Azari

Kouchakinejad–Eramsadati

et al. 2021

BMC Pediatr

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Background Traffic accidents are one of the leading causes of death and severe injury among child occupants of vehicles in most countries. This has led to the consideration of how to use restraint systems for students in school buses. The purpose of the present study was to determine the percentage of students’ use of restraint systems in school transportation services in 2020. Methods In the present cross-sectional observational study, seatbelt use was assessed in 400 students in school transport vehicles using a checklist. The observation team sat at their vehicle, at the nearest location on one of the three sides of the school’s entrance: they had by manually registering the variable in the checklist. They focused on exactly the first vehicle parked next to the school entrance. There were two other observers to validate the observations. Data were analyzed by SPSS software (version 21). Results The rate of using restraint systems was 11.3%, use of restraint systems in the Sport Utility Vehicles (SUVs) was significantly higher (P < 0.03), in areas with medium income (P < 0.009) and low income (p < 0.012) as well as when the students were sitting in the rear seats, using the seatbelt were significantly lower (P < 0.001). Seatbelt use in students was less in services driven by drivers over the age of 40 (P < 0.01) and more in vehicles driven by female drivers (P < 0.003) and newer vehicles (p < 0.001). Conclusion School authorities must enforce traffic safety rules for school transportation services. These rules should be taught to drivers, families, and students. A restraint system must be mandatory for all students. School officials must equip their buses with seatbelts and employ school bus assistants to encourage wearing seatbelts and prevent students from standing.

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Determinants of long-term health-related quality of life in adult patients with mild traumatic brain injury

Cited by 16 publications

References 33 publications

Adult attention-deficit/hyperactivity disorder symptoms, cognitive dysfunction and quality of life in high-dose use of benzodiazepine and Z-drug

Adult attention-deficit/hyperactivity disorder symptoms, cognitive dysfunction and quality of life in high-dose use of benzodiazepine and Z-drug

Factors Associated with Quality of Life in Adults with Persistent Post-Concussion Symptoms

A study of students’ use of restraint systems in school transportation services in primary and secondary schools in northern Iran: an observational study

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