Determinants of left ventricular untwisting behaviour in patients with dilated cardiomyopathy: analysis by two-dimensional speckle tracking

Saito, Makoto; Okayama, Hideki; Nishimura, Kazuhisa; Ogimoto, Akiyoshi; Ohtsuka, Tomoaki; Inoue, Kentaro; Hiasa, Go; Sumimoto, Takumi; Funada, Junichi; Shigematsu, Yuji; Higaki, Jitsuo

doi:10.1136/hrt.2008.145979

Cited by 44 publications

(41 citation statements)

References 36 publications

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“…Currently, 2DST is available to detect regional myocardial deformation in various cardiac diseases. [3][4][5][6][7][8][9] Furthermore, the sensitivity of high-frame 2DST in the circumferential direction was recently assessed in rat and mouse models with very thin myocardial thickness, 12,13 and this technique can be used in the clinical setting. Therefore, we applied it to the carotid arterial wall, because this technique enables the measurement of strain in very thin tissue segments with high reproducibility.…”

Section: Discussionmentioning

confidence: 99%

“…However, CS was semi-automatically measured using 2DST software with high reproducibility. [3][4][5][6][7][8][9]12,13 The difference in measurement methods may account for the significantly better reproducibility of e circ compared with b. Second, e circ is a parameter Carotid arterial circumferential strain M Saito et al that directly measures the elasticity of the carotid arterial wall in the circumferential direction, whereas b is an indirect parameter that measures the change of the internal luminal diameter of the artery in the radial direction.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9] Although this method can be applied to the human carotid arterial wall to directly assess arterial elasticity, it has not been well assessed. Therefore, the aims of this study were to evaluate the feasibility of direct measurement of peak circumferential strain (CS) of the carotid arterial wall using 2DST, to compare the reproducibility of CS with conventional arterial stiffness parameters in healthy subjects, and to compare CS between subjects with and without hypertension.…”

Section: Introductionmentioning

confidence: 99%

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Carotid arterial circumferential strain by two-dimensional speckle tracking: a novel parameter of arterial elasticity

Saito¹,

Okayama

Inoue

et al. 2012

Hypertens Res

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Recently, the development of two-dimensional speckle-tracking (2DST) technology has allowed the direct measurement of the elastic parameters of the carotid arterial wall. The aims of this study were to determine the feasibility of measuring peak circumferential strain (CS) of the carotid arterial wall using 2DST and to compare this value with conventional arterial stiffness parameters in subjects with and without hypertension. The study included 90 healthy subjects and 40 age-and sex-matched patients with hypertension. The short-axis view of the right common carotid artery was recorded. The CS in the posterior region of the carotid artery was calculated by 2DST using special software and corrected by the following equation: e circ ¼ ln (systolic blood pressure/diastolic blood pressure)/CS. We simultaneously measured the stiffness index b (b) at the same location and the brachial-ankle pulse wave velocity (baPWV). Sixty randomly selected healthy subjects were used to assess the inter/ intra-observer variability of e circ and b. In healthy subjects, e circ was significantly correlated with b, age and baPWV. These correlations were slightly better than the corresponding correlations of b with age and baPWV. The hypertensive patients had a significantly larger e circ than the healthy subjects (0.112 ± 0.074 vs. 0.066 ± 0.029/%, Po0.001). The inter/intra-observer variability for e circ was significantly lower than that for b. Our data suggest that the measurement of carotid e circ using 2DST is feasible and has better reproducibility than conventional carotid arterial stiffness.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Carotid arterial circumferential strain by two-dimensional speckle tracking: a novel parameter of arterial elasticity

Saito¹,

Okayama

Inoue

et al. 2012

Hypertens Res

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“…2,3 It has been proposed that LV twist is a sensitive marker of changes in both regional and global LV function. [4][5][6] Recently, efforts have focused on 2D speckle-tracking imaging (STI) to assess LVrot. [7][8][9] Several studies have shown that 2D STI gives equivalent results when compared to magnetic resonance imaging (MRI) or Doppler tissue imaging (DTI) for measuring LVrot.…”

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confidence: 99%

Three-Dimensional Speckle-Tracking Imaging for Left Ventricular Rotation Measurement

Zhou

Ashraf

et al. 2010

Journal of Ultrasound in Medicine

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Objective. Left ventricular (LV) twist is manifested in oppositely directed apical and basal rotation. We studied a new 3-dimensional (3D) echocardiography program (wall motion tracking; Toshiba America Medical Systems, Inc, Tustin, CA) for left ventricular rotation. Methods. We used a rotation model with a variable-speed motor to rotate hearts in a water bath. We studied 10 freshly harvested pig hearts, which were mounted on the rotary actuator of our twist phantom with the heart base rotating and the apex held fixed to avoid translational motion, at rotations of 0°, 15°, 20°, and 25°. Full-volume 3D image loops were acquired on a Toshiba Aplio Artida ultrasound system at a maximized frame rate. Results. As the actual heart rotation increased, computed segmental and global rotation also increased accordingly, with the measured rotations of the basal and middle segments greater than that of the apex (both P < .001). Segmental and global rotation at all 3 levels correlated well with the actual rotation (base: r = 0.93; middle: r = 0.92; apex: r = 0.82; global: r = 0.95; all P < .001). Conclusions. The new 3D program tracked LV rotation accurately. Key words: left ventricular rotation; speckle tracking; 3-dimensional imaging. esearch in clinical deformation cardiac mechanics has recently been focused on 2-dimensional (2D) left ventricular (LV) deformation studies, including LV twist and LV rotation (LVrot). 1 Left ventricular twist may be related to the helical fiber orientation of the LV, which results in opposing rotational directions of the apex and the base and which determines the magnitude of this torsional deformation. 2,3 It has been proposed that LV twist is a sensitive marker of changes in both regional and global LV function. [4][5][6] Recently, efforts have focused on 2D speckle-tracking imaging (STI) to assess LVrot. [7][8][9] Several studies have shown that 2D STI gives equivalent results when compared to magnetic resonance imaging (MRI) or Doppler tissue imaging (DTI) for measuring LVrot. 9 However, because of the 3-dimensional (3D) nature of cardiac deformation, 2D STI based on 2D imaging may not be robust enough for LVrot measurement because of speckle decorrelation or the loss of some speckles due to elevational

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“…The magnitude of untwisting rate also correlated with systolic torsion, relaxation time constant, and intraventricular pressure gradient. A reduced and delayed peak untwisting rate was found to occur with increasing age ) and in patients with dilated cardiomyopathy (Saito et al 2009). However, in patients with isolated diastolic dysfunction, peak untwisting increased in mild cases, but was depressed in severe cases (Park et al 2008).…”

Section: Rotational Motionmentioning

confidence: 99%

Right Ventricular Pacing and Mechanical Dyssynchrony

Burns¹,

Gage²,

Bank³

2012

Electrophysiology - From Plants to Heart

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Determinants of left ventricular untwisting behaviour in patients with dilated cardiomyopathy: analysis by two-dimensional speckle tracking

Abstract: These results suggest that strain-based LV radial dyssynchrony and E/e' as well as LV torsion are related to diastolic untwisting behaviour in patients with DCM.

Cited by 44 publications

References 36 publications

Carotid arterial circumferential strain by two-dimensional speckle tracking: a novel parameter of arterial elasticity

Carotid arterial circumferential strain by two-dimensional speckle tracking: a novel parameter of arterial elasticity

Three-Dimensional Speckle-Tracking Imaging for Left Ventricular Rotation Measurement

Right Ventricular Pacing and Mechanical Dyssynchrony

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