Determinants of left ventricular mass in obesity; a cardiovascular magnetic resonance study

Rider, Oliver J; Francis, Jane M; Ali, Mohammed K.; Byrne, James P.; Clarke, Kieran; Neubauer, Stefan; Petersen, Steffen E.

doi:10.1186/1532-429x-11-9

Cited by 97 publications

(88 citation statements)

References 34 publications

(35 reference statements)

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“…Also, TAT correlated weakly with LV mass ( r = 0.26; p = 0.009). Both these relationships were weaker than those reported in the general population ( r = 0.5 for lean body mass and r = 0.6 for fat)5, 6 perhaps because chronic catabolic disease results in additional variation in organ mass not present in healthy individuals. We recently discussed that in human patients with chronic hypercatabolic diseases both atrophied and hypertrophied hearts could be significantly associated with severe muscle depletion 1.…”

mentioning

confidence: 58%

Concurrent depletion of skeletal muscle, fat, and left ventricular mass in patients with cirrhosis of the liver

Kazemi‐Bajestani

Becher

Ghosh³

et al. 2015

Journal of Cachexia, Sarcopenia and Muscle

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mentioning

confidence: 58%

Concurrent depletion of skeletal muscle, fat, and left ventricular mass in patients with cirrhosis of the liver

Kazemi‐Bajestani

Becher

Ghosh³

et al. 2015

Journal of Cachexia, Sarcopenia and Muscle

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“…лептин был положительно ас-социирован с ГЛЖ (R2=0,079, p=0,04) в ходе простого регрессионного анализа при изучении предикторов ГЛЖ у 38 пациентов с ожирением без сопутствующих ССЗ с помощью магнитно-резонансной томографии. Однако в множественной регрессии лептин не смог вы-ступить в качестве независимого предиктора ГЛЖ [8].…”

Section: Discussionunclassified

“…Роль избытка лептина или его дефицита в формировании ги-пертрофии миокарда остается противоречивой. Нами изучены работы, в которых в одном случае уровень лептина крови выступал независимым предик тором ГЛЖ [8], а в другом был отрицательно связан с увели-чением индекса (ИММЛЖ) [9]. Адипонектин является одним из адипоцитокинов, роль которого в патогенезе ожирения и ассоциированных с ним заболеваний ак-тивно изучается в настоящее время.…”

Section: ожирение и метаболизмunclassified

Analysis of left ventricular hypertrophy predictors in women with different levels of obesity

Постоева¹,

Викторовна²,

Dvoryashina³

et al. 2015

Obes. metabol.

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Introduction. Previous studies have shown that patients with obesity had left ventricular hypertrophy (LVH) in 27–69,4% cases along with normal geometry of left ventricle (LV).Aim. To investigate new possible clinical and hormonal predictors of LVH in women with obesity of different degrees.Materials and methods. We conducted trans-sectional study in women with obesity, we performed clinical examination and echocardiography with calculation of mass of myocardium of LV (MMLV), indexed MMLV (IMMLV) to body surface area and relative wall thickness (RWT). LVH was diagnosed at IMMLV≥95 g/m2, increase of RWT when RWT≥0.42. Blood levels of fasting insulin, leptin and adiponectin were investigated. Differences between groups were assessed with Student’s t-test for independent samples, U-criterion of Mann-Whitney and Chi-square test (χ2). Correlation was estimated with Spearman's coefficient (rs). Multiple and logistic regression analyses were performed for detection of predictors. Statistics were performed with SPSS (version 13.0), differences were significant at level p0.05.Results. We assessed the results in 113 women (age 44.34±11.18 years, body mass index 35.0±5.3 kg/m2). Total 67 women were diagnosed with LVH (59.3%), 56.5% among them had arterial hypertension (AH). Increase of RWT was revealed in 25 participants (22.1%), 80% of them had arterial hypertension (AH). Levels of fasting leptin, insulin and adiponectin did not differ in groups of women with or without LVH, with or without increase of RWT. In multiple regression age (β=1.67, p=0,005), body mass (BM) (β=2.63, p=0.004) and mean blood pressure (BP) (β=1.07, p=0.009) were independent predictors of MMLV increase; age (β=0.83, p=0.006) and mean BP (β=0.56 p=0.007) – predictors of IMMLV increase. In logistic regression age (odds ratio (OR)=1.058, p=0.036) and BM (OR=1.065, p=0.05) were independent predictors of LVH; presence of AH (OR=4.011, p=0.05) and level of adiponectin (OR=2.618, p=0.048) – predictors of RWT increase.Conclusions. Women with obesity with or without AH had LVH in 59.3% cases. Age and BM were independent positive predictors of LVH, presence of AH and adiponectin – independent positive predictors of increase of RWT of LV.

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“…15 Another study found that30 obese children aged 11.2 (SD 2.9) years had a mean left ventricular mass of 98.5 (36.4) g. 16 Left ventricular hypertrophy detected by echocardiography is a risk factor for morbidity and mortality in cardiovascular disease. Obesity in children and adolescents is the main factor that determines left ventricular mass.…”

Section: Discussionmentioning

confidence: 99%

High sensitivity C-reactive protein, left ventricular mass, and systolic function in obese adolescents

Kaunang

As’ad

Warouw

et al. 2016

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Determinants of left ventricular mass in obesity; a cardiovascular magnetic resonance study

Cited by 97 publications

References 34 publications

Concurrent depletion of skeletal muscle, fat, and left ventricular mass in patients with cirrhosis of the liver

Concurrent depletion of skeletal muscle, fat, and left ventricular mass in patients with cirrhosis of the liver

Analysis of left ventricular hypertrophy predictors in women with different levels of obesity

High sensitivity C-reactive protein, left ventricular mass, and systolic function in obese adolescents

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