Determinants of immunity to murine salmonellosis: studies involving immunization with lipopolysaccharide-lipid A-associated protein complexes in C3H/HeJ mice

Protection against the lethal effect and arthritogenic capacity of serovar O: 3 for mice

“…Comparison of results between active and passive humoral protection experiments suggests that pertinent amounts of homologous antibodies to the LPS are sufficient to neutralize the lethal effect of Ca2+-dependent bacterial cells. C3H/HeJ mice are currently considered as hyporesponsive to the O determinants of LPS [20][21][22]; however, if appropriately stimulated, they do respond [23][24][25]. Following vaccination with live bacterial cells, they produced antibodies to the 0:3 antigen in a degree comparable to Swiss and even higher than BALB/c mice.…”