Determinants of Heterogeneous Adherence to HIV-Antiretroviral Therapies in the Multicenter AIDS Cohort Study

Kleeberger, Cynthia A.; Phair, John P.; Strathdee, Steffanie A.; Detels, Roger; Kingsley, Lawrence; Jacobson, Lisa P.

doi:10.1097/00042560-200101010-00012

Cited by 115 publications

(72 citation statements)

References 37 publications

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“…The majority (67%) had started treatment with HAART in the previous three years and 66% were symptomatic when the treatment was prescribed. Alcohol consumption was referred by 30% of the patients, past use of illicit drugs by 16.5% and present use by 6%.…”

Section: Resultsmentioning

confidence: 99%

“…The association between socioeconomic condition and non-adherence is controversial, although divergences can be partly explained by the differences among the groups studied 16,21,33 . There is, however, an increasing inclination to consider socioeconomic condition (as assessed through income, level of education, job and housing conditions) as having a poor predictive power, except in cases of extreme poverty 9,14 .…”

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confidence: 99%

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Risk-factors for non-adherence to antiretroviral therapy

Silva

Ximenes

Filho

et al. 2009

Rev. Inst. Med. trop. S. Paulo

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SUMMARYCross-sectional study analyzed as case-control to identify risk factors for non-adherence to antiretroviral therapy. We studied 412 out-clinics HIV infected subjects of three public hospitals of Recife, Pernambuco. The objective was to examine the association between non-adherence to the antiretroviral therapy and biological, social-behavior and demographics and economic factors, factors related to the disease and/or treatment, factors related to life habits and depression symptoms. Variables significantly associated with non-adherence to antiretroviral therapy were: time elapsed since HIV diagnosis (p = 0.002), daily dose (p = 0.046), use of alcohol (p = 0.030) and past drug use (p = 0.048), and borderline p-values were found for educational level (p = 0.093) and family monthly income (p = 0.08). In the multivariable analysis, the factors that remained in the final model were family monthly income, time period with HIV infection and use of alcohol. No association was observed between non-adherence to antiretroviral therapy and gender, age, sexual orientation, marital status, educational level and place of residence.Based on our results and the local situation we suggest: assessment of social needs; training of partners and/or families on supporting adherence, creation of "adherence groups" to motivate and to reassure patients on the benefits of treatment; counseling and/or psychotherapy for alcohol drinkers.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Risk-factors for non-adherence to antiretroviral therapy

Silva

Ximenes

Filho

et al. 2009

Rev. Inst. Med. trop. S. Paulo

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“…Ese tiempo puede variar de una persona a otra y depende, entre otras cosas, del lapso transcurrido desde el diagnóstico de seropositividad al VIH, de los antecedentes clínicos -especialmente de algunas afecciones asociadas con esta infección-, del tipo de tratamiento empleado o de la cantidad de medicamentos que se consume diariamente (25)(26)(27).…”

Section: Discussionunclassified

Asociación entre los niveles de estrés y depresión y la adhesión al tratamiento en personas seropositivas al VIH en Hermosillo, México

López¹,

Tapia²,

Sosa³

et al. 2008

Rev Panam Salud Publica

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“…In addition, previous research indicates that patient factors related to socioeconomic status (SES), such as child/family care concerns, literacy/education levels, and lack of transportation, may contribute to noncompliance among patients in the treatment of breast carcinoma and other diseases. [31][32][33][34][35] Noncompliance may contribute to the significantly poorer survival among African-American women who receive equivalent treatment.…”

Section: Discussionmentioning

confidence: 99%

Racial differences in treatment and survival from early‐stage breast carcinoma

Joslyn

2002

Cancer

108

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BACKGROUNDAfrican‐American women have a significantly worse prognosis from breast carcinoma compared with white women, even when the stage at diagnosis is equivalent. The purpose of this study was to analyze racial differences in the treatment (use of breast‐conserving surgery and radiation therapy) of women with early‐stage breast carcinoma and the resulting effects on survival rates.METHODSSubjects included 10,073 African‐American and 123,127 white women diagnosed with Stage I, IIA, or IIB breast carcinoma in the National Cancer Institute's Surveillance, Epidemiology, and End Results program between 1988 and 1998. Comparisons were made by race with treatment, age, hormone receptor status, and stage at the time of diagnosis. Survival analyses were conducted to compare risk of death for African‐American and white women while controlling for age, stage, and hormone receptor status.RESULTSAmong women diagnosed with early‐stage breast carcinoma who receive breast‐conserving surgery, African‐American women were significantly less likely to receive follow‐up radiation therapy in every 10‐year age group except in the older than 85 age group. Whether treatment was equivalent or suboptimal, survival for African‐American women with early‐stage breast carcinoma was significantly worse. However, when treatment was equivalent, the effects of racial differences on survival were significantly less compared with survival associated with suboptimal treatment.CONCLUSIONSSignificant racial differences exist in the treatment of women with early‐stage breast carcinoma. Public health efforts to eliminate suboptimal treatment would reduce, but not eliminate, racial disparity in survival. Cancer 2002;95:1759–66. © 2002 American Cancer Society.DOI 10.1002/cncr.10827

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Determinants of Heterogeneous Adherence to HIV-Antiretroviral Therapies in the Multicenter AIDS Cohort Study

Cited by 115 publications

References 37 publications

Risk-factors for non-adherence to antiretroviral therapy

Risk-factors for non-adherence to antiretroviral therapy

Asociación entre los niveles de estrés y depresión y la adhesión al tratamiento en personas seropositivas al VIH en Hermosillo, México

Racial differences in treatment and survival from early‐stage breast carcinoma

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