“…Classification criteria have standardised definitions, which aim to include key features of disease to identify a homogenous population of patients with a high specificity for research [ 4 , 5 ]. Given that CTDs, beyond lupus, are associated with significant morbidity, mortality and impairment in health-related quality of life [ 6 , 7 ], clinical trials must be generalisable to our patient-population for them to be useful.…”