Determinants of health-related quality of life in people with Parkinson’s disease: a path analysis

Soh, Sze‐Ee; McGinley, Jennifer; Watts, Jennifer J.; Iansek, Robert; Murphy, Anna; Menz, Hylton B.; Huxham, Frances; Morris, Meg E.

doi:10.1007/s11136-012-0289-1

Cited by 107 publications

(105 citation statements)

References 43 publications

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“…Additionally, GABS scores had good correlations with measures of balance, disease severity, and functional independence. Th ese results are consonant with the view that balance and gait disturbances are strongly associated with disability and poor quality of life in patients with mild to moderate PD 8 . Balance defi cits and falls are frequent clinical problems in patients with PD 5,22 .…”

Section: Discussionsupporting

confidence: 85%

“…In the long term, most of the survivors experience falls and around 1/3 sustain fractures 6 . Gait and balance difficulties significantly affect the quality of life of patients with PD, and frequent falls are associated with greater disease severity and increased caregiver burden 5,7,8 . In this scenario, the analysis of balance and gait in patients with PD is an essential step in the context of the clinical evaluation.…”

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confidence: 99%

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Validation of the Brazilian version of the Clinical Gait and Balance Scale and comparison with the Berg Balance Scale

Baggio

Curtarelli

Rodrigues

et al. 2013

Arq. Neuro-Psiquiatr.

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Objective: To validate the Clinical Gait and Balance Scale (GABS) for a Brazilian population of patients with Parkinson's disease (PD) and to compare it to the Berg Balance Scale (BBS). Methods: One hundred and seven PD patients were evaluated by shortened UPDRS motor scale (sUPDRSm), Hoehn and Yahr (HY), Schwab and England scale (SE), Falls Efficacy Scale International (FES-I), Freezing of Gait Questionnaire (FOG-Q), BBS and GABS. Results: The internal consistency of the GABS was 0.94, the intra-rater and inter-rater reliability were 0.94 and 0.98 respectively. The area under the receiver operating characteristic (ROC) curve was 0.72, with a sensitivity of 0.75 and specificity of 0.6, to discriminate patients with a history of falls in the last twelve months, for a cut-off score of 13 points. Conclusions: Our study shows that the Brazilian version of the GABS is a reliable and valid instrument to assess gait and balance in PD.Key words: Parkinson's disease, balance, gait, validation studies. RESUMO Objetivo: Validar a Escala Clínica de Marcha e Equilíbrio (GABS) para a população brasileira com doença de Parkinson (DP) e compará-la com a Escala de Equilíbrio de Berg (BBS).Métodos: 107 pacientes com diagnóstico de DP foram avaliados através das escalas versão reduzida da UPDRS motora, Hoehn e Yahr, Schwab e England, Escala de Medo de Quedas Internacional, Escala de Congelamento da Marcha, GABS e BBS. Resultados: A consistência interna da escala foi 0,94, a confiabilidade inter-examinador 0,98 e intra-examinador 0,94. Curva ROC (receiver operating characteristic curve) de 0,72, com sensibilidade de 0,75 e especificidade de 0,60 para discriminar pacientes com história de queda nos últimos 12 meses, para uma nota de corte de 13 pontos. Conclusão: Nosso estudo demonstra que a versão brasileira da GABS é válida para avaliar a marcha e o equilíbrio em pacientes com DP.Palavras-Chave: doença de Parkinson, equilíbrio, marcha, estudos de validação.

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Section: Discussionsupporting

confidence: 85%

mentioning

confidence: 99%

Validation of the Brazilian version of the Clinical Gait and Balance Scale and comparison with the Berg Balance Scale

Baggio

Curtarelli

Rodrigues

et al. 2013

Arq. Neuro-Psiquiatr.

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“…Structural equation modeling was used to evaluate the fit of the final model by examining a number of statistics. To examine the magnitude of the discrepancy between the sample and fitted covariance matrices, the χ 2 test was used when a nonsignificant test indicated that the model and data were consistent [22] . The comparative fit index examines the difference in overall fit among the models, and values >0.95 indicate a good model fit.…”

Section: Discussionmentioning

confidence: 99%

“…The comparative fit index examines the difference in overall fit among the models, and values >0.95 indicate a good model fit. The root mean square error of approximation evaluates the approximate fit of the model, with values <0.005 suggesting a reasonable goodness of fit [22] . Table 1 presents the clinical characteristics and serum adipokine levels of the patients with CU classified into the responsive and refractory groups, as well as the healthy controls (controls).…”

Section: Discussionmentioning

confidence: 99%

Altered Systemic Adipokines in Patients with Chronic Urticaria

Trinh¹,

Pham²,

Ban³

et al. 2016

Int Arch Allergy Immunol

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Background: Increasing evidence suggests that adipokines affect immune responses and chronic urticaria (CU) is associated with an altered immune response related to chronic systemic inflammation. Our objectives were to investigate whether adipokines are involved in CU pathogenesis and to outline relationships between adipokines and urticaria severity and quality of life. Methods: Serum adiponectin, leptin, lipocalin-2 (LCN2), interleukin (IL)-10, IL-6, and tumor necrosis factor (TNF)-α concentrations were measured by enzyme-linked immunosorbent assays in 191 CU patients and 89 healthy controls. The effect of LCN2 on N-formyl-methionine-leucine-phenylalanine (fMLP)-induced neutrophil chemotaxis was assessed using migration assays. CU severity was assessed based on the urticaria activity score (UAS). To explore relationships between adipokines and UAS and the chronic urticaria-specific quality of life (CU-QoL) questionnaire, a structural equation model was used. Results: Mean levels of serum LCN2, TNF-α, IL-6, and IL-10 were significantly higher in CU patients than in controls. Adiponectin levels were significantly lower in patients with CU than in controls. While serum IL-6 levels were significantly higher in refractory CU patients, compared to responsive CU individuals, LCN2 levels were significantly lower. LCN2 inhibited fMLP-induced neutrophil migration. LCN2 showed a direct relationship with UAS (β = -0.274, p < 0.001), and UAS was found to contribute to CU-QoL (β = 0.417, p < 0.001). Conclusions: Our results highlighted an imbalance in pro- and anti-inflammatory adipokines in CU patients. We suggest that LCN2 could be a differential marker for disease activity and the clinical responses to antihistamine treatment in CU patients. Modulation of systemic inflammation may be a therapeutic strategy for treating severe, refractory CU.

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“…Reduced participation is a risk factor for lower QOL post-stroke and in PD [11][12][13], and is associated with increased incidence of depression [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Choral singing therapy following stroke or Parkinson’s disease: an exploration of participants’ experiences

Fogg‐Rogers

Buetow

Talmage

et al. 2015

Disability and Rehabilitation

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Determinants of health-related quality of life in people with Parkinson’s disease: a path analysis

Cited by 107 publications

References 43 publications

Validation of the Brazilian version of the Clinical Gait and Balance Scale and comparison with the Berg Balance Scale

Validation of the Brazilian version of the Clinical Gait and Balance Scale and comparison with the Berg Balance Scale

Altered Systemic Adipokines in Patients with Chronic Urticaria

Choral singing therapy following stroke or Parkinson’s disease: an exploration of participants’ experiences

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