Determinants of Health-Related Quality of Life in Long-Term Survivors of Hodgkin's Lymphoma

Wettergren, Lena; Björkholm, Magnus; Axdorph, Ulla; Langius‐Eklöf, Ann

doi:10.1023/b:qure.0000040790.43372.69

Cited by 103 publications

(121 citation statements)

References 41 publications

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“…The Pearson Mean, standard deviation and range of the SCT group of adults (n ¼ 53) as compared with average stature and weight (mean) of men and women in Sweden. 25 product moment correlation coefficient was used to assess construct validity by correlating SWED-QUAL and SOC-13 with HAD. Inter-correlation between health variables and the HRQL instrument and SOC and HAD were also examined.…”

Section: Discussionmentioning

confidence: 99%

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Health-related quality of life in adult survivors after paediatric allo-SCT

Löf

Winiarski

Giesecke

et al. 2008

Bone Marrow Transplant

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Fifty-three adults who had received SCT as children responded to questionnaires on health-related quality of life (HRQoL) (Swedish HRQoL survey (SWED-QUAL)), sense of coherence (SOC), anxiety and depression (HAD) and a health and symptom inventory. Late effects were classified following the Common Terminology Criteria for Adverse Events (CTCAE) v. 3.0. HRQoL was below norm in 9 of 13 SWED-QUAL domains. Poorest domains (Po0.001) were satisfaction with physical health, general health, partner relations and sexual function, whereas emotional wellbeing and satisfaction with family life were on par with the norm. Older age, time elapsed post-SCT and fewer self-reported symptoms correlated with better HRQoL. Unfavourable late effect scores had no or limited impact, whereas age at SCT or TBI did not adversely affect HRQoL. Most subjects were well subjectively and objectively, whereas 24% had more complicated late effects. The median Karnofsky score was 90, 13% of subjects having scores below 80. In total, 53% reported pain, whereas 42.5% had memory and concentration problems. Anxiety and/or depression, reported by 35%, were associated with lower HRQoL and SOC ratings. Overall, 55% reported infertility and expressed difficulty with this. To conclude, childhood SCT did not negatively affect overall health for most of these adult long-term survivors, although poorer HRQoL with psychological and cognitive problems are common.

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Section: Discussionmentioning

confidence: 99%

“…A score sum of 8-10 indicates possible clinical problems, and greater than 11 suggests a clear clinical case. [23][24][25] In the current study, the Cronbach's alpha coefficient was 0.85 for the anxiety scale and 0.87 for the depression scale.…”

Section: Assessment Of Health and Disabilitymentioning

confidence: 99%

Health-related quality of life in adult survivors after paediatric allo-SCT

Löf

Winiarski

Giesecke

et al. 2008

Bone Marrow Transplant

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“…12 It has subsequently been successfully used in numerous studies of QoL as part of the SEIQoL-DW interview. 10,[13][14][15][16] In this study the direct-weighting procedure was applied to the five domains of QoL included in the FACT-P interview. Subjects were asked to weight the relative importance of each of these domains using a pie chart.…”

Section: Assessmentsmentioning

confidence: 99%

Quality of life in patients with prostate cancer: development and application of a hybrid assessment method

Stone

Matar

et al. 2008

Prostate Cancer Prostatic Dis

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Investigator-derived quality of life (QoL) instruments such as the Functional Assessment of Cancer Therapy-Prostate (FACT-P) questionnaire do not allow participants to weight the relative importance of QoL domains. We investigated the effect of allowing patients the ability to weight the relative importance of the five areas included in the FACT-P (Physical, Social, Emotional and Functional well-being, and Additional concerns). Patients (n ¼ 150) completed the FACT-P and gauged the relative importance of each QoL domain using a direct-weighting approach. This was then used to provide an adjusted Hybrid QoL score. Patients also completed a Visual Analogue Scale. Patients considered Social well-being to be the most important domain and Additional concerns to be the least important. When patient weightings were taken into account overall QoL scores increased. The validity of the Hybrid score was supported by its ability to distinguish between patients with metastatic and locoregional disease and its ability to detect expected decreases in global QoL over time. Application of the direct-weighting approach to the FACT-P allows assessments to more accurately reflect individual QoL. Unadjusted QoL scores may lead researchers to incorrectly estimate the true QoL of respondents.

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“…In a study out of the Southwest Oncology Group in the United States, a comparison of HRQOL in patients treated with either EFRT or CMT found persistent fatigue reported by survivors of each treatment modality, but again without differences according to treatment. [87] Effects seem to wane as length of time post-treatment increases; HL survivor 10 years from treatment continue to report lower general health scores, but many specific QOL domains no longer differ between treated patients and age-matched controls. [88,89] …”

Section: Health Related Quality Of Lifementioning

confidence: 99%

“…[86,87,90] Chronic fatigue is three times more likely in HL survivors than in age matched controls, and is less likely to be associated with poor mental health than in untreated patients who experience chronic fatigue. [89,91] Retrospective studies have attempted to characterize pre-existing risk factors that can predict post-treatment chronic fatigue, and reports have implicated B symptoms at diagnosis, social isolation, and presence of treatment-related pulmonary toxicity.…”

Section: Chronic Fatiguementioning

confidence: 99%