Determinants of Exercise Tolerance After Acute Myocardial Infarction in Older Persons.

The effect of major depression on postexercise cardiovascular recovery

“…The study had several strengths, including a large sample size and clinical assessment of MDD. Also, while corroborating previous findings indicating poorer fitness in many depressed individuals (Lavoie et al, 2004; Marchionni et al, 2000; Ruo, Rumsfeld, Pipkin, & Whooley, 2004), by statistically adjusting for exercise capacity, the results indicate that the association between MDD and HR recovery is unlikely to be solely due to differences in fitness. In this respect, the results are consistent with Hughes et al's (2008) second study.…”

Relationship between cardiopulmonary fitness and depressive symptoms in cardiac rehabilitation patients with coronary artery disease

“…A significant correlation between VO 2 peak and CES-D scores was identified in a population of patients with CAD entering rehabilitation. This finding is consistent with the few available reports of correlations between reduced cardiopulmonary fitness and depressive symptoms in patients with CAD (4,18). A correlation between VO 2 peak and depressive symptoms has also been identified in women showing no clinical evidence of cardiovascular disease (16) suggesting that the relationship between depressive symptoms and fitness may be of broad clinical importance.…”

“…To determine which clinical variables were the most significant independent predictors of depressive symptoms, a backward elimination linear regression model was performed. Variables associated with depression or depressive symptoms in previous studies of patients with CAD were entered into the model including the sociodemographic characteristics age, sex, smoking status and marital status, the anthropometric characteristics BMI and WHtR, resting physiology including heart rate, systolic and diastolic blood pressure, and cardiopulmonary fitness parameters, including VO 2 peak, maximum heart rate, and maximum systolic and diastolic blood pressures (4)(5)(6)(7)(8)(17)(18)(19)(20). Cardiac factors, including history of MI, PCI, CABG, congestive heart failure and cardiac arrest, and the presence of hypertension and angina pectoris, and the medical co-morbidities diabetes, COPD, cancer, renal disease and stroke that have been previously associated with depression or depressive symptoms were also entered (5,21).…”

Aging and chronic disorders

“…Using data from 265 post-MI patients in the Cardiac Rehabilitation in Advanced study, Marchionni, et al (2000) analyzed the determinants of exercise tolerance following AMI in older patients. According to their results, older age, female gender, a small body surface area, a low amount of physical activity prior to the MI, and post-MI depressive symptoms predicted lower exercise tolerance.…”