Determinants of drug-related problems among ambulatory type 2 diabetes patients with hypertension comorbidity in Southwest Ethiopia: a prospective cross sectional study

Yimama, Mohammed; Jarso, Habtemu; Desse, Tigestu Alemu

doi:10.1186/s13104-018-3785-8

Cited by 30 publications

(49 citation statements)

References 22 publications

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“…This was also supported by the study done in Wolaita, Ethiopia and Jimma, Ethiopia. 13,14 The reason might be the presence of comorbidity influencing the desired outcome of other diseases by increasing the number of drugs, causing disease-disease interactions, drug-drug interactions, drug-disease interactions which collectively results in increased likelihood of experiencing DRPs in the study patients.…”

Section: Discussionmentioning

confidence: 99%

“…11,12 In Ethiopia, the majority of studies related to DRPs in diabetic patients were conducted among patients with type 2 diabetes. [13][14][15] However, understanding the magnitude of the DRPs and their predictors among patients with type 1 and type 2 diabetes would be important in achieving the desired therapeutic outcome. 16 In addition, it may be helpful to reveal the gap in pharmaceutical care service so as to empower the focus of healthcare providers and policy makers in designing strategies to prevent the occurrence of DRP.…”

Section: Introductionmentioning

confidence: 99%

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<p>Drug-Related Problems and Their Predictors Among Patients with Diabetes Attending the Ambulatory Clinic of Gebre Tsadik Shawo General Hospital, Southwest Ethiopia</p>

Feyissa

Kebede

2020

DMSO

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Background: Patients with diabetes are vulnerable to experiencing drug-related problems. Thus, this study aimed to assess drug-related problems and their predictors among patients with diabetes attending the ambulatory clinic of Gebre Tsadik Shawo General Hospital. Methods: A cross-sectional study was conducted from September 1, 2019 to November 30, 2019. Drug-related problems were identified using the Pharmaceutical Care Network Europe version 5.01. Patient's written informed consent was obtained after explaining the purpose of the study. The data were collected using structured questionnaires and entered into Epi data version 4.0.2. Then, it was exported to SPSS version 21.0 for analysis. To identify predictors of the occurrence of drug-related problems, multiple stepwise backward logistic regression analysis was done. For the accuracy of data analysis, a 95% confidence interval was used, and statistical significance was considered at p-values <0.05. Results: From a total of 141 patients with diabetes included in the study, 58.2% of them had at least one drug-related problem during the 3-month study period. A total of 156 drugrelated problems were identified in 141 patients. Drug interactions (30.76%) and drug choice problems (25%) were the most common type of drug-related problems identified. Presence of disease comorbidity (AOR=4.12, 95% CI=1.71-9.91), poly-pharmacy (AOR=6.27, 95% CI=1.67-23.52) and more than 5 years diabetes duration (AOR=3.89, 95% CI=1.52-9.95) were independent predictors of drug-related problems. Conclusion: Drug-related problems were high among patients with diabetes in the study setting. Early detection of drug-related problems ensures the appropriateness of drug therapy. Therefore, a sustainable pharmaceutical care service is needed for early identification, prevention and resolution of drug-related problems.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Drug-Related Problems and Their Predictors Among Patients with Diabetes Attending the Ambulatory Clinic of Gebre Tsadik Shawo General Hospital, Southwest Ethiopia</p>

Feyissa

Kebede

2020

DMSO

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“…[21][22][23] Various studies have shown that age, medication non-adherence, comorbidity, polypharmacy, and history of hospitalization were independent predictors of DTPs. 16,24,25 In Ethiopia, studies revealed that DTPs are common in the healthcare system. However, there is a lack of data regarding the magnitude of DTPs and associated factors in T2DM patients with hypertension.…”

Section: Introductionmentioning

confidence: 99%

Magnitude and determinants of drug therapy problems among type 2 diabetes mellitus patients with hypertension in Ethiopia

et al. 2020

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Introduction: Type 2 diabetes mellitus patients with hypertension are at high risk of drug therapy problems since they are subject to receive multiple drug therapies due to comorbidities. Objectives: To determine the magnitude of drug therapy problems and its determinants among Type 2 diabetes mellitus patients with hypertension. Methods: A cross-sectional study was employed among 423 randomly selected participants based on the inclusion criteria. A structured questionnaire and review of patients’ medical record were employed in the data collection. The classification system used by Cipolle was used to classify and evaluate drug therapy problems. Data were analyzed using Statistical Package for the social sciences version 25.0 software. Multivariate logistic regression analysis was used to identify determinants of drug therapy problems with a statistical significance of p ⩽ 0.05. Results: A total of 491 drug therapy problems with a mean of 1.86 ± 0.53 drug therapy problems per patient were identified, and 62.4% (264) of them experienced at least one drug therapy problem. Non-compliance (197, 40.1%), needs of additional drug therapy (119, 24.2%), and dosage too low (91, 18.5%) were the most frequently observed drug therapy problems in the study setting. Anti-diabetic medications (88.4%), statins (44.5%), and aspirin (33.5%) were the most commonly involved drugs in drug therapy problems. The determinants of drug therapy problems were very low family income (adjusted odds ratio = 4.64, p = 0.010), age (45–65 years old) (adjusted odds ratio = 2.55, p = 0.008), presence of comorbidity (adjusted odds ratio = 9.19, p < 0.001), and taking ⩾5 medications (adjusted odds ratio = 2.84, p = 0.001). Conclusion: Approximately three out of five patients had one or more drug therapy problems encountered. In this study, the most common types of drug therapy problems were non-compliance, needs additional drug therapy, and dosage too low. Family monthly income, age, comorbidities, and number of medications were the significant determinants of drug therapy problems. Therefore, patient education regarding medication adherence, routine medication review, and strengthening clinical pharmacy services should be promoted.

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“…Notably, none of these prior investigations involved the identi cation of MRPs and were conducted in ambulatory pregnant patients. Although few MRPs identi cation studies were performed among hospitalized patients in the country, all focused on the non-pregnant patient population [14][15][16][17]. Thus far, no study has investigated MRPs in an obstetrics group in a hospital setting in Ethiopia.…”

Section: Introductionmentioning

confidence: 99%

Medication-related problems among hospitalized pregnant women in a tertiary teaching hospital in Ethiopia: A prospective observational study

AHMED

Sundby

Aragaw

et al. 2020

Preprint

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Background Studies on medication-related problems (MRPs) among pregnant women are scarce, despite the potential consequences for both mother and child. This study aimed to describe the prevalence, clinical significance, and risk factors for MRPs among hospitalized pregnant or postpartum women at Jimma University Medical Centre (JUMC) in Ethiopia. Methods A prospective follow-up and clinical audit of 1,117 hospitalized pregnant or postpartum women in the maternity and gynaecology wards at JUMC was carried out between February and June 2017. Patients were followed throughout their stay in the hospital to assess the presence and development of MRPs. Pre-tested data extraction form and an interview-guided structured questionnaire were used to collect data. Descriptive statistics were used to describe MRPs. Logistic regression analysis was used to identify factors associated with MRPs. Results One or more MRPs occurred among 323 (28.9%) study participants, mostly in relation to lack of iron supplementation. A total of 278 (70.6%) of all MRPs were considered to be of moderate to high clinical significance. Nulliparous women were more likely to experience MRPs than their counterparts (adjusted OR 1.82; 95% CI 1.23, 2.69). When excluding MRPs due to iron from the analysis, nulliparous women (adjusted OR 1.99; 95% CI 1.22, 3.24) and previous medication use were significantly associated with experiencing an MRP (adjusted OR 2.38; 95% CI 1.24, 4.56). Conclusions Nearly 3 out of 10 hospitalized pregnant women at JUMC had one or more MRPs. The need for additional iron therapy was by far the most common type of MRP. Improved adherence to guidelines on iron supplementation are required. Multidisciplinary approaches including physicians, nurses, and clinical pharmacists in the maternity and gynaecology wards could possibly prevent MRPs and promote patient safety for women and children.

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Determinants of drug-related problems among ambulatory type 2 diabetes patients with hypertension comorbidity in Southwest Ethiopia: a prospective cross sectional study

Cited by 30 publications

References 22 publications

<p>Drug-Related Problems and Their Predictors Among Patients with Diabetes Attending the Ambulatory Clinic of Gebre Tsadik Shawo General Hospital, Southwest Ethiopia</p>

<p>Drug-Related Problems and Their Predictors Among Patients with Diabetes Attending the Ambulatory Clinic of Gebre Tsadik Shawo General Hospital, Southwest Ethiopia</p>

Magnitude and determinants of drug therapy problems among type 2 diabetes mellitus patients with hypertension in Ethiopia

Medication-related problems among hospitalized pregnant women in a tertiary teaching hospital in Ethiopia: A prospective observational study

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