The study examined the determinants of commercial banks profit efficiency in Nigeria. Annual data were employed and sourced from Central Bank of Nigeria Statistical Bulletin Various Issues and bank' annual financial statement of account. The data covered the period 2002-2019. The study used panel analytical techniques, such as panel unit root analysis, and panel regression. The empirical findings revealed that GTB, Skybank, Sterling bank, Union bank, Unity bank, Wema bank, and Zenith bank were profit efficient, while Access bank, Diamond bank, FCMB, Fidelity bank, First bank, and UBA were profit inefficient. Loan loss provision to net interest revenue was found to be negatively related to banks profitability. The result of banks efficiency ratio indicate that GTB, Skybank, Sterling bank, Union bank, Unity bank, Wema bank, and Zenith bank were profit efficient, while Access bank, Diamond bank, FCMB, Fidelity bank, First bank, and UBA were profit inefficient. Loan loss provision to net interest revenue was found to be negatively related to banks profitability. High incidence of nonperforming loans and overhead cost constitutes a critical element in the banking financial crisis. It is therefore recommended that banks management are advised to properly assess and monitor loans and advances, regularly review their credit policies to further reduce the incidence of non-performing loan, also constitute effective financial and legal sanction on default, exorbitant chief executive officer's and other top staff members' salaries that are not tied to performance should be reduced. Other strategies for desolation of non-performing loan should be put in place since AMCOM has not lived up to expectation. If checked, this will significantly reduce banking industry costs