Determinants of Brachial-Ankle Pulse Wave Velocity in Chinese Patients with Rheumatoid Arthritis

Li, Ping; Han, Cheng-xun; Ma, Cuili; Guo, Jialong; Liu, Bo; Du, Juan; Bi, Liqi

doi:10.1155/2013/342869

Cited by 6 publications

(5 citation statements)

References 38 publications

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“…We are not aware of studies who examined the relationship between ANA and cfPWV. Finally, our findings regarding the missing association between aortic stiffness and RA disease duration are in agreement with other RA/cfPWV studies (Mäki-Petäjä et al 2006 ; Provan et al 2011 ; Li et al 2013 ).…”

Section: Discussionsupporting

confidence: 93%

The count of tender rather than swollen joints correlates with aortic stiffness in patients with rheumatoid arthritis

et al. 2016

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BackgroundPatients with rheumatoid arthritis (RA) are at a higher cardiovascular (CV) risk in comparison to the general population. CV risk associates closely with aortic stiffness. Aim of this exploration was therefore to evaluate aortic stiffness in patients with RA and to examine its association with various RA associated parameters as well as with traditional CV risk factors.MethodsMeasurements of carotid-femoral pulse wave velocity (cfPWV) were analyzed retrospectively in 38 RA patients and 25 controls. We investigated the statistical difference between cfPWV values in the two groups. Furthermore, we analyzed the associations of cfPWV with laboratory and clinical RA parameters including Disease Activity Score 28 and its components, rheumatoid factor, cyclic citrullinated peptide antibodies, antinuclear antibodies and RA duration. Finally, we explored the relationship of cfPWV with traditional CV risk factors in the RA group.ResultscfPWV was not significantly higher in RA patients in comparison to controls in an adjusted statistical model for confounding factors [−0.587 95 % CI (−1.38 to 0.201), p = 0.144]. Among RA patients there was a statistically significant correlation of cfPWV with age (rho = 0.544, p = 0.001) and the count of tender joints [0.051 95 % CI (0.008–0.207), p = 0.034]. Finally, C-reactive protein associated only marginally with cfPWV [0.105 95 % CI (−0.410 to 0.003), p = 0.053].ConclusionsIn RA patients the number of tender, rather than swollen joints correlates with stiffness of the aorta, as measured through cfPWV. Therefore, RA associated joint pain might play a role in the development of aortic stiffness and thus increase CV risk.

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Section: Discussionsupporting

confidence: 93%

The count of tender rather than swollen joints correlates with aortic stiffness in patients with rheumatoid arthritis

et al. 2016

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“…In other studies, repeatability of AIx were examined, where intra-observer ICC ranged from 0.75 to 0.96 [47] – [49] and inter-observer ICC ranged from 0.92 to 0.93 [47] ; Intra-observer ICC of PWV ranged from 0.75 to 0.92 [50] – [52] and inter-observer ICC of PWV was 0.88 [53] ; The intra-observer ICC of central systolic blood pressure reconstruct from transfer function was 0.74 in resting state [48] . Comparing to other index of PWA, the harmonic components are competitive and reliable.…”

Section: Discussionmentioning

confidence: 99%

Development of a Standard Protocol for the Harmonic Analysis of Radial Pulse Wave and Assessing Its Reliability in Healthy Humans

Chang

Chen

Wang

2015

IEEE J. Transl. Eng. Health Med.

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This study was aimed to establish a standard protocol and to quantitatively assess the reliability of harmonic analysis of the radial pulse wave measured by a harmonic wave analyzer (TD01C system). Both intraobserver and interobserver assessments were conducted to investigate whether the values of harmonics are stable in successive measurements. An intraclass correlation coefficient (ICC) and a Bland–Altman plot were used for this purpose. For the reliability assessments of the intraobserver and the interobserver, 22 subjects (mean age 45 ± 14 years; 14 males and 8 females) were enrolled. The first eleven harmonics of the radial pulse wave presented excellent repeatability (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$\text {ICCs}>0.9$ \end{document} and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$\text {p}<0.001$ \end{document}) for the intraobserver assessment and high reproducibility (ICCs range from 0.83 to 0.96 and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$\text {p}<0.001$ \end{document}) for the interobserver assessment. The Bland–Altman plot indicated that more than 90% of harmonic values fell within two standard deviations of the mean difference. Thus, we concluded that the harmonic analysis of the radial pulse wave using the TD01C system is a feasible and reliable method to assess a hemodynamic characteristic in clinical trial.

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“…Higher arterial stiffness correlated with elevated nighttime SBP and the non-dipping pattern [ 21 ]. In addition, higher levels of triglycerides, total cholesterol, low-density lipoprotein (LDL), glucose, and increased body mass index (BMI) were seen in our discussed population [ 3 , 5 , 6 , 13 , 22 , 23 , 24 ]. Many studies ruled out smokers from study groups because of the evident vasoconstrictor effect, and only some studies showed a higher prevalence of smokers [ 5 , 6 ].…”

Section: Reviewmentioning

confidence: 92%

“…Prevalence does not necessarily mean causation. High SBP, DBP, total serum cholesterol, LDL, BMI, insulin resistance, and smoking are related to vascular morphological characteristics, measured by pulse wave velocity (PWV), augmentation index (Aix), and ankle-brachial Index (ABI) [ 5 , 6 , 18 - 20 , 23 , 25 ]. ED is associated with SBP, LDL, smoking, and age [ 2 , 24 , 28 ].…”

Section: Reviewmentioning

confidence: 99%

Evaluation of the Risk of Getting Peripheral Artery Disease in Rheumatoid Arthritis and the Selection of Appropriate Diagnostic Methods

Sedrakyan

Fatima

Khatun

et al. 2020

Cureus

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This study aims to review the evidence regarding the association between peripheral artery disease (PAD) and rheumatoid arthritis (RA), as well as influential underlying factors and diagnostic options. Eligible literature was searched in PubMed published up to June 1, 2020, in English. Case studies, case series, reviews, and meta-analyses were excluded. We also excluded non-human studies and those 20 years and older. A total of 44 studies were finally incorporated in the narrative review. The results indicated that compared to controls, RA patients are more prone to PAD. Traditional risk factors, disease-characteristics, vitamin D deficiency, therapy used, and other relevant conditions have a variable effect on overall PAD progression. Studies comparing diagnostic options revealed that vascular function and morphology are connected but are still distinctive processes. In early-stage disease, there are functional alterations in the endothelium that can be controlled by anti-inflammatory medications. Ankle-Brachial Index (ABI) <0.9 might not be quite susceptible to PAD evaluation. Supplemental diagnostic tools could detect vascular disease in the preclinical stage. Most risk factors are adjustable, and the management will have a good impact on vascular health. PAD is mostly subclinical when the therapeutic options have a better impact. Diagnostic modalities should be chosen depending on the features of RA. In addition, multiple diagnostic options increase the accuracy of PAD diagnosis. Future prospective studies with larger populations at different age groups and different disease activity duration are essential to make firm conclusions and better understand the phenomenon of RA and PAD.

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Determinants of Brachial-Ankle Pulse Wave Velocity in Chinese Patients with Rheumatoid Arthritis

Cited by 6 publications

References 38 publications

The count of tender rather than swollen joints correlates with aortic stiffness in patients with rheumatoid arthritis

The count of tender rather than swollen joints correlates with aortic stiffness in patients with rheumatoid arthritis

Development of a Standard Protocol for the Harmonic Analysis of Radial Pulse Wave and Assessing Its Reliability in Healthy Humans

Evaluation of the Risk of Getting Peripheral Artery Disease in Rheumatoid Arthritis and the Selection of Appropriate Diagnostic Methods

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