Determinants of bone mineral density in obese premenopausal women

Bredella, Miriam A.; Torriani, Martin; Ghomi, Reza Hosseini; Thomas, Bijoy J.; Brick, Danielle J.; Gerweck, Anu V.; Harrington, Lindsey M.; Breggia, Anne; Rosen, Clifford J.; Miller, Karen K.

doi:10.1016/j.bone.2010.12.011

Cited by 154 publications

(148 citation statements)

References 50 publications

(57 reference statements)

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“…Quantitative computed tomography (QCT) was used to assess body composition and lumbar trabecular BMD. There was an inverse association between BMD and VAT, independent of age and BMI (88). Finally, in unpublished work, Shane and colleagues have shown that trunk fat, as measured by DXA, was inversely related to trabecular bone volume fraction and bone formation rate by histomorphometry (Cohen, 2012 submitted).…”

Section: Bone and Energy Metabolismmentioning

confidence: 95%

“…In Korean healthy men and women, it was found that visceral fat, measured by computed tomography, was independently and negatively associated with bone mass (87). Aligned with these studies, Bredella et al evaluated in 68 obese (BMI=36.7±4.2 kg·m -2 ) premenopausal women the differential effects of abdominal fat depots and muscle on trabecular BMD of the lumbar spine (88). Quantitative computed tomography (QCT) was used to assess body composition and lumbar trabecular BMD.…”

Section: Bone and Energy Metabolismmentioning

confidence: 99%

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Bone Remodeling and Energy Metabolism: New Perspectives

Paula

Rosen

2013

Bone Res.

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Bone mineral, adipose tissue and energy metabolism are interconnected by a complex and multilevel series of networks. Calcium and phosphorus are utilized for insulin secretion and synthesis of high energy compounds. Adipose tissue store lipids and cholecalciferol, which, in turn, can influence calcium balance and energy expenditure. Hormones long-thought to solely modulate energy and mineral homeostasis may influence adipocytic function. Osteoblasts are a target of insulin action in bone. Moreover, endocrine mediators, such as osteocalcin, are synthesized in the skeleton but regulate carbohydrate disposal and insulin secretion. Finally, osteoblasts and adipocytes originate from the same mesenchymal progenitor. The mutual crosstalk between osteoblasts and adipocytes within the bone marrow microenvironment plays a crucial role in bone remodeling. In the present review we provide an overview of the reciprocal control between bone and energy metabolism and its clinical implications.

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Section: Bone and Energy Metabolismmentioning

confidence: 95%

Section: Bone and Energy Metabolismmentioning

confidence: 99%

Bone Remodeling and Energy Metabolism: New Perspectives

Paula

Rosen

2013

Bone Res.

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“…15 There is a strong correlation between BMD and BMI, and several studies have shown that a decrease in body weight leads to bone loss. 81 A recent meta-analysis investigated the association between BMI and future fracture risk at different skeletal sites and concluded that low BMI remains a risk factor for hip and all osteoporotic fractures. 80 Even when adjusted for BMD, low BMI remains a risk factor for hip fracture.…”

Section: Body Mass Indexmentioning

confidence: 99%

A review of lifestyle, smoking and other modifiable risk factors for osteoporotic fractures

Abrahamsen¹,

Brask-Lindemann

Rubin

et al. 2014

BoneKEy Reports

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Although many strong risk factors for osteoporosis-such as family history, fracture history and age-are not modifiable, a number of important risk factors are potential targets for intervention. Thus, simple, non-pharmacological intervention in patients at increased risk of osteoporotic fractures could include reduction of excessive alcohol intake, smoking cessation, adequate nutrition, patient education, daily physical activity and a careful review of medications that could increase the risk of falls and fractures. There remains, however, an unmet need for high-quality intervention studies in most of these areas.

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“…New reports, however, show that abdominal obesity may actually be an independent risk factor for bone mass loss and development of osteoporosis [26].…”

Section: Obesitymentioning

confidence: 99%

Impact of eating disorders on quality of life of women during the perimenopausal period

Ostrzyżek¹

2013

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SummaryEating disorders pose a serious medical, clinical and social problem. In the recent years cases of the lack of appetite are more often diagnosed in reference to middle-aged and elderly women. A situation like this may result from an existing disease process, a continuation of experiencing such problems in the past, and also a reflection of the trends being created by the modern media advocating the need for keeping a woman's physical attractiveness in her late adulthood. It happens more and more often that the effort to reduce weight achieve a slimmer look is taken by women in their 50s, and even 60s. There is also an existing view that eating disorders among elderly women appear in a close connection to psychical disorders. Many women perceive menopause as a loss and a sign of an oncoming old age, thus they are focused mainly on negative emotions in this period of life. On the basis of depression-like disorders, there appear problems with controlling and maintaining the body mass. Although the scale of the phenomenon has still a limited range and character, its significant impact on life quality of women's population in the menopausal period justifies the execution of the current review of the subject literature in this matter.Key words: menopause, eating disorders, quality of life. StreszczenieZaburzenia odżywiania stanowią istotny problem medyczny, kliniczny i społeczny. W ostatnich latach przypadki występowania zaburzeń łaknienia coraz częściej diagnozuje się u kobiet w średnim i starszym wieku. Sytuacja taka może być wynikiem istniejącego procesu chorobowego, kontynuacją doświadczania problemów tego typu w przeszłości, jak również odzwierciedleniem kreowanych przez współczesne media trendów, głoszą-cych potrzebę zachowania atrakcyjności fizycznej przez kobiety w późnej dojrzałości. Coraz częściej zdarza się, że wysiłek obniżenia wagi i uzyskania szczupłego wyglądu podejmują kobiety po 50., a nawet 60. roku życia. Istnieje również pogląd, że zaburzenia odżywiania u kobiet w starszym wieku pojawiają się w ścisłym związku z innymi zaburzeniami psychicznymi. Wiele kobiet postrzega menopauzę w kategoriach straty i zapowiedzi bliskiej starości, dlatego skupia się w tym okresie życia głównie na negatywnych emocjach. Na podłożu zaburzeń o typie depresji pojawiają się problemy z kontrolą i utrzymaniem masy ciała. Jakkolwiek skala zjawiska ma wciąż ograniczony zasięg i charakter, jej znaczący wpływ na jakość życia populacji kobiet w okresie menopauzalnym uzasadnia dokonanie aktualnego przeglądu literatury przedmiotu w tym zakresie.Słowa kluczowe: menopauza, zaburzenia odżywiania, jakość życia. Impact of eating disorders on quality of life of women during the perimenopausal periodWp³yw zaburzeñ od¿ywiania na jakooeae ¿ycia kobiet w okresie oko³omenopauzalnym

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Determinants of bone mineral density in obese premenopausal women

Cited by 154 publications

References 50 publications

Bone Remodeling and Energy Metabolism: New Perspectives

Bone Remodeling and Energy Metabolism: New Perspectives

A review of lifestyle, smoking and other modifiable risk factors for osteoporotic fractures

Impact of eating disorders on quality of life of women during the perimenopausal period

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