Determinants of Bone Mineral Density in Transgender Youth

Marwa, Albara; Misra, Madhusmita; López, Ximena

doi:10.1089/trgh.2020.0111

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…Nonetheless, we found no association between vitamin D values and BMD, in contrast with previously reported data [26][27][28]. This discrepancy with previous studies could be due to: a) young age of participants in the COMET study, which could diminish the cumulative effect of hypovitaminosis D on bone density over lifetime and b) the average level of vitamin D in our sample falls under the category of insufficiency -not deficiency.…”

Section: Discussioncontrasting

confidence: 99%

Bone health and body composition in transgender adults before gender-affirming hormonal therapy: data from the COMET study

Ceolin,

Scala,

Dall’Agnol

et al. 2023

J Endocrinol Invest

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Purpose Preliminary data suggested that bone mineral density (BMD) in transgender adults before initiating gender-affirming hormone therapy (GAHT) is lower when compared to cisgender controls. In this study, we analyzed bone metabolism in a sample of transgender adults before GAHT, and its possible correlation with biochemical profile, body composition and lifestyle habits (i.e., tobacco smoke and physical activity). Methods Medical data, smoking habits, phospho-calcic and hormonal blood tests and densitometric parameters were collected in a sample of 125 transgender adults, 78 Assigned Females At Birth (AFAB) and 47 Assigned Males At Birth (AMAB) before GAHT initiation and 146 cisgender controls (57 females and 89 males) matched by sex assigned at birth and age. 55 transgender and 46 cisgender controls also underwent a complete body composition evaluation and assessment of physical activity using the International Physical Activity Questionnaire (IPAQ). Results 14.3% of transgender and 6.2% of cisgender sample, respectively, had z-score values < -2 (p = 0.04). We observed only lower vitamin D values in transgender sample regarding biochemical/hormonal profile. AFAB transgender people had more total fat mass, while AMAB transgender individuals had reduced total lean mass as compared to cisgender people (53.94 ± 7.74 vs 58.38 ± 6.91, p < 0.05). AFAB transgender adults were more likely to be active smokers and tend to spend more time indoor. Fat Mass Index (FMI) was correlated with lumbar and femur BMD both in transgender individuals, while no correlations were found between lean mass parameters and BMD in AMAB transgender people. Conclusions Body composition and lifestyle factors could contribute to low BMD in transgender adults before GAHT.

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Section: Discussioncontrasting

confidence: 99%

Bone health and body composition in transgender adults before gender-affirming hormonal therapy: data from the COMET study

Ceolin,

Scala,

Dall’Agnol

et al. 2023

J Endocrinol Invest

View full text Add to dashboard Cite

show abstract

“…Retrospective and small uncontrolled cohort studies in trans youth have shown that even prior to GnRHa, bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) may be lower than in age-matched youth. (1)(2)(3) This is largely determined by factors such as lower body mass index, low vitamin D, suboptimal calcium intake, and lower physical activity. (1)(2)(3) After GnRHa treatment, BMD declines, but there are also associated increases in body fat including in bone marrow adipose tissue.…”

mentioning

confidence: 99%

“…(1)(2)(3) This is largely determined by factors such as lower body mass index, low vitamin D, suboptimal calcium intake, and lower physical activity. (1)(2)(3) After GnRHa treatment, BMD declines, but there are also associated increases in body fat including in bone marrow adipose tissue. (4) After gender-affirming hormone therapy, BMD Z-scores increase but may well remain below age-matched peers.…”

mentioning

confidence: 99%