Determinants of bone mass in end‐stage renal failure patients at the time of kidney transplantation

Dolgos, Szilveszter; Hartmann, Anders; Bønsnes, Stine; Ueland, Thor; Isaksen, Gunhild Aker; Godang, Kristin; Pfeffer, Per; Bollerslev, Jens

doi:10.1111/j.1399-0012.2008.00810.x

Cited by 38 publications

(26 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Finally, the non-linear association between serum iPTH and BMD could also, in part, be responsible for the conflicting results. A negative correlation between serum iPTH and BMD measured at different sites was reported by several researchers [9,23,26], but the linearity of this association was not analyzed. Gerakis et al reported that vertebral BMD was not different between the different types of renal osteodystrophy (ROD) assessed by bone biopsy.…”

Section: Discussionmentioning

confidence: 82%

Bone mineral density and parathyroid function in patients on maintenance hemodialysis

et al. 2010

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 82%

Bone mineral density and parathyroid function in patients on maintenance hemodialysis

et al. 2010

View full text Add to dashboard Cite

show abstract

“…This may be responsible for the lower than expected prevalence of osteopenia and osteoporosis as well as the lack of associations with other parameters [10]. In maintenance hemodialysis patients, the decrease in BMD is largely associated with aging, female gender, low body weight, elevated PTH, increased alkaline phosphatase, and prolonged dialysis vintage [11,12,13,14]. In the present study, total hip BMD showed negative relationship with aging and alkaline phosphatase levels while demonstrating positive associations with body weight and serum phosphate.…”

Section: Discussionmentioning

confidence: 99%

Low Hip Bone Mineral Density Predicts Mortality in Maintenance Hemodialysis Patients: A Five-Year Follow-Up Study

Disthabanchong¹,

Jongjirasiri²,

Adirekkiat³

et al. 2014

Blood Purif

View full text Add to dashboard Cite

Background: Bone loss is common among hemodialysis patients and contributes to mortality. The association between bone loss and vascular calcification may explain the increased mortality risk. Studies on the association between decreased bone mass and mortality in maintenance hemodialysis patients are limited. Methods: Eighty-three hemodialysis patients underwent bone mineral density (BMD) and coronary artery calcification (CAC) measurements. The relationship between BMD and mortality was analyzed after a 5-year follow-up period. Results: Eighty percent of the patients had reduced hip BMD. In univariate Cox regression analyses, age, cardiovascular disease, dyslipidemia, increased CAC score, increased comorbidity score and decreased hip BMD were associated with mortality. Low hip BMD remained independently associated with mortality after adjustments for cardiovascular risk factors, comorbidity score and CAC score. Patients with BMD in the lowest tertile had the worst survival. Conclusion: Low hip BMD predicted mortality in maintenance hemodialysis patients independent of CAC.

show abstract

“…Since the publication of our meta-analysis, three additional studies [46][47][48] have been published which report on the association between BMD and fracture in patients with stage 5 CKD and two of these [46,47] report an inverse association between BMD and prevalent fracture, but few other details are provided.…”

Section: The Role Of Bone Mass Measurements In Ckdmentioning

confidence: 99%

Fracture risk assessment in patients with chronic kidney disease

2011

View full text Add to dashboard Cite

Fractures are common in patients with chronic kidney disease (CKD) and associated with substantially high morbidity and mortality. Bone mass measurements are commonly used to assess fracture risk in the general population, but the utility of these measurements in patients with CKD, and specifically among those on hemodialysis, is unclear. This review will outline the epidemiology and etiology of fractures in patients with CKD with a particular emphasis on men and women on hemodialysis. As well, we will summarize the published data, which describes the association between risk factors for fracture (including bone mass measurements, biochemical markers of mineral metabolism, and muscle strength) and fractures in patients with CKD. Patients with CKD suffer from fractures due to impairments in bone quantity, bone quality, and abnormalities of neuromuscular function. There is a paucity of evidence on the associations between bone quality, bone turnover markers, neuromuscular function, and fractures in patients with CKD. Furthermore, the complex etiology of fractures combined with the technical limitations of bone mineral density testing, both by dual energy X-ray absorptiometry (DXA) and by peripheral quantitative tomography (pQCT), limits the clinical utility of bone mass measurements for fracture prediction in CKD; this is particularly true among patients with stages 4 and 5 CKD. Further prospective studies to identify noninvasive measures of bone strength that can be used for fracture risk assessment are needed.

show abstract

Determinants of bone mass in end‐stage renal failure patients at the time of kidney transplantation

Cited by 38 publications

References 18 publications

Bone mineral density and parathyroid function in patients on maintenance hemodialysis

Bone mineral density and parathyroid function in patients on maintenance hemodialysis

Low Hip Bone Mineral Density Predicts Mortality in Maintenance Hemodialysis Patients: A Five-Year Follow-Up Study

Fracture risk assessment in patients with chronic kidney disease

Contact Info

Product

Resources

About