Determinants of Blood Uric Acid Levels in a Dyslipidemic Arab Population

Abstract

Objectives: The objective of this study was to explore the relationships between circulating uric acid and lipid levels and components of the metabolic syndrome (MetS) in Arab dyslipidemic patients, a group already at high coronary artery disease risk. Subjects and Methods: The medical records of 1,229 subjects (632 men, 597 women) referred for treatment of dyslipidemia and followed up for at least 12 months were reviewed. Serum levels of uric acid and lipids (total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein) and other variables in the National Cholesterol Education Program ATP III criteria definition of MetS were assessed at initial presentation and every 4– 6 months, under specific lipid-lowering treatment (statins and/or fibrates), in each of the subjects. Their respective associations were explored by appropriate logistic regression techniques with control for confounding risk factors, including age, gender and body mass index. Results: 306 subjects (24.9%) of the study population were hyperuricemic; they were more likely to be men, obese and diabetic. Also the serum uric acid level (mean ± SD) was greater in men with MetS compared with men without (377.0 ± 98.0 vs. 361.6 ± 83.1 µmol/l, p < 0.05), an observation not reproduced in women. Uric acid levels had significant associations with the presence of fasting hyperglycemia, hypertension and large waist circumference (WC) in men, but only with large WC in women. With statin treatment, uric acid levels decreased by 10% within 1 year of treatment; with fibrates, uric acid levels remained unchanged or slightly increased. Conclusion: The data showed that hyperuricemia is common in dyslipidemic patients in Kuwait, where its important determinants are male sex, obesity, diabetes and statin treatment.

Role of Serum Uric Acid in the Assessment of Stroke

“…In this study significant relationship was observed between uric acid and dyslipidaemia similar results were also found in cross sectional study conducted with acute stroke patients Firoozgar Hospital, [5] cross-sectional study with 60 cases of acute ischemic stroke, [8] retrospective and crosssectional, longitudinal component, the database of the lipid clinic, Mubarak Al-Kabeer hospital, Kuwait, [18] a study group comprised of 100 newly detected type 2 diabetic patients in the age group of 30-60 years control group 100 age and sex matched healthy participants, [19] a cross-sectional study conducted with 280 general adult participants recruited from university staff, university students, city people and individuals who went to the local clinic for the routine health check-up in Sylhet and Dhaka cities of Bangladesh. [20] Elevated SUA levels were significantly found among those with dyslipidaemia with high triglycerides.…”

Association of hyperuricemia with metabolic syndrome among university workers: sex and occupational differences

“…This observation concurs with findings from a previous longitudinal study17. Al-Meshaweh et al,26 also reported that hyperuricemia was common in dyslipidemic patients. A plausible explanation may be related to dietary factors since hypertriglyceridemia and hyperuricemia are linked by a common denominator: a diet rich in fructose.…”

Increased Serum Uric Acid Levels Are Correlated with Decreased Left Atrial Appendage Peak Flow Velocity in Patients with Atrial Fibrillation

“…Elevated serum uric acid levels have been suggested as a simple and independent predictor of morbidity and mortality in patients with congestive heart failure [ 10 ]. Elevated serum uric acid levels were also found as an independent predictor of cardiovascular events and mortality in patients with coronary artery disease, ST-elevation myocardial infarction [ 11 ], hypertension [ 12 ], stroke [ 13 ], diabetes mellitus [ 14 ], metabolic syndrome [ 15 ], insulin resistance [ 14 ], obesity [ 16 ] and renal failure [ 17 ]. These findings pointed out that serum uric acid is not only an indicator of the catabolic phase of purine nucleotides but also a manifestation of systemic inflammation in many cardiovascular diseases.…”