Determinants of Arterial Stiffness in Female Patients with Takayasu Arteritis

Neto, Nilton Salles Rosa; Levy‐Neto, Maurício; Tolezani, Elaine Cristina; Bonfá, Eloísa; Bortolotto, Luiz Aparecido; Pereira, Rosa Maria Rodrigues

doi:10.3899/jrheum.131110

Cited by 17 publications

(29 citation statements)

References 34 publications

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“…Moreover, TAK was significantly associated with ba-PWV independently of age, blood pressure, or lipid profile. Two previous studies demonstrated that TAK is associated with higher arterial stiffness, which was measured by cf-PWV and cr-PWV (carotid-radial PWV) in one study 14) and cf-PWV in another study 15) . They have relatively small sample sizes (10 14) and 27 15) patients with TAK).…”

Section: Discussionmentioning

confidence: 96%

“…Two previous studies demonstrated that TAK is associated with higher arterial stiffness, which was measured by cf-PWV and cr-PWV (carotid-radial PWV) in one study 14) and cf-PWV in another study 15) . They have relatively small sample sizes (10 14) and 27 15) patients with TAK). The arterial stiffness was demonstrated higher in patients with TAK comparing with normal controls, and it did not correlate with ESR or CRP.…”

Section: Discussionmentioning

confidence: 96%

“…Arterial stiffness may be an important risk factor with important clinical application value for patients with TAK. Previous studies demonstrated that the arterial stiffness, measured as carotid-femoral pulse wave velocity (cf-PWV), was increased in patients with TAK 14,15) . However, these studies are limited because of their small sample sizes of patients with TAK (10 14) and 27 15) patients with TAK).…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Previous studies demonstrated that the arterial stiffness, measured as carotid-femoral pulse wave velocity (cf-PWV), was increased in patients with TAK 14,15) . However, these studies are limited because of their small sample sizes of patients with TAK (10 14) and 27 15) patients with TAK). Moreover, the use of cf-PWV as a measurement of arterial stiffness in the patients with TAK is probably not appropriate because of its low reproducibility.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…At present, both cf-PWV and ba-PWV are a widely used measure of arterial stiffness in clinical settings. Cf-PWV was used as a measure of arterial stiffness in the previous two studies 14,15) , and ba-PWV was used in the present study. Cf-PWV reflects the arterial stiffness in large central arteries between carotid and femoral arteries.…”

Section: Ba-pwv and The Disease Activity Of Takmentioning

confidence: 99%

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Brachial-Ankle Pulse Wave Velocity is Increased and Associated with Disease Activity in Patients with Takayasu Arteritis

Dang

2020

JAT

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Takayasu arteritis (TAK) is a rare inflammatory large-vessel vasculitis with increased cardiovascular morbidity and mortality. Brachial-ankle pulse wave velocity (ba-PWV) is a widely used measure of arterial stiffness and serves as an indicator of either cardiovascular risk or severity of vascular damage. However, the studies about the relationship between TAK and ba-PWV are limited. This study aimed to investigate the use of ba-PWV in the patients with TAK. Methods: Sixty-seven patients with TAK and 67 age and sex matched healthy controls were recruited. Patients with TAK were grouped according to disease activity. The routine hematological parameters and ba-PWV were summarized. Results: Ba-PWV was significantly higher in the patients with TAK than in the healthy controls (P 0.001). Ba-PWV was significantly higher in the patients with active TAK than in the patients with inactive TAK (P 0.04). Multiple liner regression analysis indicated that TAK (363.97, P 0.013), and mean arterial pressure (MAP) (8.52, P 0.012) were independently related to ba-PWV. Ba-PWV did not correlate with C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in overall patients with TAK (both P 0.05). In patients with TAK without immunosuppressive therapy, ba-PWV significantly correlated with CRP (r 0.419, P 0.008) but not ESR (P 0.05). Multiple logistic regression analysis indicated that ba-PWV was an independent predictor of active TAK in overall patients with TAK (OR 1.003, 95% CI 1.000-1.007; P 0.040) and patients with TAK without immunosuppressive therapy (OR 1.006, 95% CI 1.001-1.012; P 0.031). Conclusions: Being significantly increased in patients with TAK, ba-PWV is significantly associated with TAK disease activity, and it probably correlates with systematic inflammation. by adventitial thickening and cellular infiltration of the tunica media, with local destruction of vascular smooth muscle cells and elastin 3). It causes blood-vessel wall thickening, dilation or aneurysm, arterial stenosis, and progressive occlusion, resulting in hypertension, ischemia, aortic regurgitation, and absent or reduced pulses. TAK is associated with a significantly increased risk of cardiovascular diseases 4-6). Arterial stiffness is an important and independent predictor of future cardiovascular events and all-Copyright©2019 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.

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Section: Discussionmentioning

confidence: 96%