Determinants of 1‐year changes in disease‐specific health status in patients with advanced chronic obstructive pulmonary disease: A 1‐year observational study

Abstract

We aimed to identify baseline and longitudinal determinants of change in disease-specific health status in patients with advanced chronic obstructive pulmonary disease (COPD). Demographic and clinical characteristics as well as disease-specific health status (St George's Respiratory Questionnaire, SGRQ) were assessed in 105 outpatients with advanced COPD at baseline and at 4, 8 and 12 months. Eighty-five patients (81.0%) had complete SGRQ data at baseline and 12 months and were included in analyses. Stepwise multiple regression analysis revealed that lower SGRQ total score, higher depression scores and longer time needed to complete the Timed Up and Go (TUG) test at baseline, as well as increase in time needed to complete the TUG test and increase in dyspnoea during the 1-year follow-up period, were predictors of deterioration in disease-specific health status. The current study reinforces the stimulation of physical mobility and the targeting of dyspnoea as components for treatment programs to optimize disease-specific health status in patients with advanced COPD.

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“…Because worse health status has been shown to be associated with diminished physical functioning (44,45), it is not unexpected that the impairment in health status corresponded to the functional impairment in our cohort. Indeed, impairments in health status were most pronounced in the SGRQ activity domain.…”

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“…Cruz et al 30 Jacome et al 33 Butcher Rausch-Osthoff et al 38 Canuto et al 35 Ozalevli et al 36 Puhan et al 37 Rocco et al 40 Van To stand up and sit down on the 46 to 48 cm chair as many times as possible within 1 minute..…”

“…32 Mesquita et al 31 Horie et al 20 Beauchamp et al 29 Butcher et al 19 n= 85 (34.3±13.6%) n=95 (33 [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] To stand up from a chair and walk 3 meters at usual speed, turn and walk back to the chair and sit down again.…”