Determinants and seasonality of major structural birth defects among newborns delivered at primary and referral hospital of East and West Gojjam zones, Northwest Ethiopia 2017–2018: case–control study

Tsehay, Binalfew; Shitie, Desalegn; Lake, Akilog; Abebaw, Erimiyas; Taye, Amisalu; Essa, Enatinesh

doi:10.1186/s13104-019-4541-4

Cited by 18 publications

(41 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From these studies, one study from the Tigray region revealed that the incidence of NTDs was related to dietary diversity scores. 20 The other case-control study done 41 at selected hospitals of East and West Gojjam zones of the Amhara region found 58 NTDs from a total of 100 cases (all forms of congenital anomalies). This study revealed that folic acid supplementation, being alcoholic, and the use of herbal medicine was associated with all forms of congenital malformations.…”

Section: Resultsmentioning

confidence: 99%

“…Risk factors for NTDs were reported by 6 case-control studies, 20,25,26,32,40,41 which were done in different regions of the country. In the 6 studies, a total of 476 cases (NTDs) and 1472 controls were analyzed.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, a study done at selected hospitals of the Amhara region reported that being alcoholic and the use of herbal medicine were found to have an association with all forms of congenital malformations. 41 This could be due to alcohol-induced abnormal embryogenesis and the teratogenic effect of alcohol, which may cause the abnormal formation of the nervous system. 58 …”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, the current work is the first systematic review and meta-analysis that explored the prevalence of NTDs and associated factors among children in Ethiopia. After intense searching, data were explored and analyzed from a total of 15 studies 20,23-27,29,31,32,36-41 conducted in different regions of the country. From these studies, 10 studies 23,24,26,27,29,31,36-39 were used to compute the pooled prevalence of NTDs and 6 studies 20,25,26,32,40,41 were used for identifying the risk factor of NTDs.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, we explored data from 6 studies 20,25,26,32,40,41 to identify the risk and protective factors associated with NTDs among children by reviewing 476 cases and 1472 controls. Accordingly, sex of the child, age of the mother during pregnancy, parity >3, and a history of stillbirth were found to not be associated with NTDs using random-effect model.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Magnitude and Associated Factors of Neural Tube Defects in Ethiopia: A Systematic Review and Meta-Analysis

Bitew

Worku

Alebel

et al. 2020

Global Pediatric Health

View full text Add to dashboard Cite

Neural tube defects remain a major problem in developing countries, but there are limited comprehensive national reports to date in Ethiopia. Therefore, this study aimed to assess the prevalence of neural tube defects and associated factors in Ethiopia. Electronic databases and other sources were used to retrieve studies. Fifteen out of 862 studies were included in the final analysis. The estimated pooled prevalence of neural tube defects among children in Ethiopia was 63.3 cases per 10 000 children. The pooled prevalence of spinal bifida, anencephaly, and encephalocele was 41.09, 18.90, and 1.07 per 10 000 children, respectively. Previous family history and unplanned pregnancy were risk factors for neural tube defects. Folic acid supplementation during the first trimester of pregnancy was found to be protective. Neural tube defects are widespread in Ethiopia. Hence, fortification of food with folic acid or folic acid supplementation during childbearing age is recommended.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Magnitude and Associated Factors of Neural Tube Defects in Ethiopia: A Systematic Review and Meta-Analysis

Bitew

Worku

Alebel

et al. 2020

Global Pediatric Health

View full text Add to dashboard Cite

show abstract

The effect of substance use during pregnancy on neonatal outcomes in Ethiopia: A systematic review and meta-analysis

Bayih

Belay

Ayalew

et al. 2021

Heliyon

View full text Add to dashboard Cite

Background Substance use during pregnancy mainly khat chewing (20%) and alcohol drinking (18.1%) are commonly practiced in Ethiopia. However, the effect of using these substances has not been studied nationally yet. Thus, this study was aimed to examine national evidence about the effect of substance use during pregnancy on birth outcome in the country, 2020. Methods Primary studies were accessed through Google scholar, HINARI, SCOPUS and PubMed databases. The methodological and evidence quality of the included studies were critically appraised by the modified Newcastle-Ottawa quality assessment tool scale adapted for observational studies. From eligible studies, two authors extracted author/year, study region, study design, sample size and reported effect of antenatal substance use on birth outcome on an excel spreadsheet. During critical appraisal and data extraction, disagreements between the two authors were resolved by the involvement of a third author. The extracted data were then exported to stata version 14. Effect sizes were pooled using the fixed-effects model due to homogenous primary studies (I 2 = 0.0%). Presence of publication bias was detected from asymmetry of funnel plot and statistically significant Egger's test (p = 0.000). Results In this systematic review and meta-analysis, a total of 5,343 mother-neonate pairs were included from 15 studies. Alcohol, khat, cigarette and narghile were used during pregnancy, and significant adverse birth outcomes attributable to these substances were reported. From the pooled effect of alcohol use, drinking mothers were twice (95%CI: AOR = 2.16; 1.16, 3.17) likely to have newborns with birth defect; 9 times (95% CI: AOR = 9.39; 2.84, 15.94) more prone to own low birth weight neonates; and 1.9 times more prone to deliver preterm neonates (95% CI: AOR = 1.93; 0.52, 3.33) than the nondrinkers. Khat users were 2.4 times (95%CI: AOR = 2.4; 1.11, 5.19) more likely to have congenitally defected neonates; and 3.1 times (95%CI: AOR = 3.19; 1.01, 5.37) more risked to possess low birth weight neonates. Furthermore, antenatal cigarette smokers (95% CI: AOR = 4.36 (1.75, 6.98)) and narghile users (95% CI: AOR = 20.1; 3.94, 103) were at 4 and 20 times more likelihood of having low birth weight neonates as compared to their counterparts. Conclusion Prematurity, low birth weight and congenital malformation were the investigated adverse effects of antenatal substance use in Ethiopia. Therefore, the existing public health efforts should be encouraged to help women stop using these substances completely before pregnancy. Moreover, increasing public awareness about the potential negative impacts of substance use during pregnancy on birth outcome would be of greatest importance for comprehensive prevention of the problem.

show abstract

Birth prevalence and risk factors of neural tube defects in Ethiopia: a systematic review and meta-analysis

Tesfay,

Hailu,

Habtetsion

et al. 2023

BMJ Open

View full text Add to dashboard Cite

ObjectiveThis study aims to estimate the prevalence of neural tube defects (NTDs) and to identify potential risk factors in the Ethiopian context.Study designSystematic review and meta-analysis.Study participantsA total of 611 064 participants were included in the review obtained from 42 studies.MethodsPubMed (Medline), Embase and Cochrane Library databases in combination with other potential sources of literature were systematically searched, whereby studies conducted between January 2010 and December 2022 were targeted in the review process. All observational studies were included and heterogeneity between studies was verified using Cochrane Q test statistics and I2test statistics. Small study effects were checked using Egger’s statistical test at a 5% significance level.ResultThe pooled prevalence of all NTDs per 10 000 births in Ethiopia was 71.48 (95% CI 57.80 to 86.58). The between-study heterogeneity was high (I2= 97.49%, p<0.0001). Birth prevalence of spina bifida (33.99 per 10 000) was higher than anencephaly (23.70 per 10 000), and encephalocele (4.22 per 10 000). Unbooked antenatal care (AOR 2.26, 95% CI (1.30 to 3.94)), preconception intake of folic acid (AOR 0.41, 95% CI (0.26 to 0.66)), having chronic medical illness (AOR 2.06, 95% CI (1.42 to 2.99)), drinking alcohol (AOR 2.70, 95% CI (1.89 to 3.85)), smoking cigarette (AOR 2.49, 95% CI (1.51 to 4.11)), chewing khat (AOR 3.30, 95% CI (1.88 to 5.80)), exposure to pesticides (AOR 3.87, 95% CI (2.63 to 5.71)), maternal age ≥35 (AOR 1.90, 95% CI (1.13 to 3.25)), maternal low educational status (AOR 1.60, 95% CI (1.13 to 2.24)), residing in urban areas (AOR 0.75, 95% CI (0.58 to 0.97))and family history of NTDs (AOR 2.51, 95% CI (1.36 to 4.62)) were associated with NTD cases.ConclusionThe prevalence of NTDs in Ethiopia is seven times as high as in other Western countries where prevention measures are put in place. Heredity, maternal and environmental factors are associated with a high prevalence of NTDs. Mandatory fortification of staple food with folic acid should be taken as a priority intervention to curb the burden of NTDs. To smoothen and overlook the pace of implementation of mass fortification, screening, and monitoring surveillance systems should be in place along with awareness-raising measures.PROSPERO registration numberCRD42023413490.

show abstract

Determinants and seasonality of major structural birth defects among newborns delivered at primary and referral hospital of East and West Gojjam zones, Northwest Ethiopia 2017–2018: case–control study

Cited by 18 publications

References 34 publications

Magnitude and Associated Factors of Neural Tube Defects in Ethiopia: A Systematic Review and Meta-Analysis

Magnitude and Associated Factors of Neural Tube Defects in Ethiopia: A Systematic Review and Meta-Analysis

The effect of substance use during pregnancy on neonatal outcomes in Ethiopia: A systematic review and meta-analysis

Birth prevalence and risk factors of neural tube defects in Ethiopia: a systematic review and meta-analysis

Contact Info

Product

Resources

About