Determinants and prognostic value of left atrial volume in patients with dilated cardiomyopathy

Rossi, Andrea; Cicoira, Mariantonietta; Zanolla, Luisa; Sandrini, Rita; Golia, Giorgio; Zardini, Piero; Enríquez-Sarano, Maurice

doi:10.1016/s0735-1097(02)02305-7

Cited by 320 publications

(217 citation statements)

References 31 publications

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“…In a previous study by Christiaens et al [17], the LAVmax, LAVmin and LAEF were measured using 64-MSCT, but the other left atrial functional variables were not evaluated. The left atrial function is impaired in a number of cardiovascular outcomes [2][3][4][5][18][19][20]. With abnormal LV relaxation, the relative contribution of the LA reservoir and the LA contractile function increases, and the conduit function decreases.…”

Section: Discussionmentioning

confidence: 99%

“…The principal function of the LA is to modulate left ventricular (LV) filling and the cardiovascular performance. It has been demonstrated that changes in the LA size and function are closely related to such cardiovascular diseases as diastolic dysfunction, cardiomyopathy, ischemic heart disease and valvular disease, and these changes act as barometers of cardiovascular outcomes [2][3][4][5][6]. The LA size and function are important factors in the development of atrial fibrillation and for determining the long term results of cardioversion.…”

Section: Introductionmentioning

confidence: 99%

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Assessing the left atrial phasic volume and function with dual-source CT: comparison with 3T MRI

Wen

Zhang

et al. 2010

Int J Cardiovasc Imaging

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We wanted to assess the performance of dual-source CT (DSCT) for evaluating the left atrial volume and function and we compared this performance to that of the standard reference technique,cardiac cine MR (CMR). Fifty-one patients who were referred for CT coronary angiography were included in the study. Two were subsequently excluded for having un-analyzable MR images at the onset of left atrial contraction. For the remaining 49 patients, the DSCT data sets and FIESTA (fast imaging employing steady-state acquisition) cines of the vertical long axis covering the left atrium and the short axis covering the left ventricle were obtained on the same day. All the images were analyzed to obtain the maximal left atrial volume (LAVmax), the minimal left atrial volume (LAVmin), the left atrial volume just before left atrium contraction (LAVp), the left atrial reservoir volume (LARV), the left atrial ejection fraction (LAEF), the left atrial passive emptying volume (LAPV), the left atrial active emptying volume(LAAV), the left atrial conduit volume (LACV), the left ventricular end-diastolic volume (LVEDV), the left ventricular end-systolic volume (LVESV) and the left ventricular stroke volume (LVSV) by using 3D semi-segmentation software and Report Card 2.0 software, respectively, for the DSCT and CMR. All the parameters were normalized to the body surface area. Intermodality agreement was tested through linear regression and Bland-Altman analyses.Repeated measurements were performed to determine the interobserver variability. The DSCT measurements resulted in good correlation (r > 0.75) compared with those of CMR. However, DSCT slightly,but insignificantly overestimated the indexed LAVmax, LAVmin, LAVp, LARV, LAPV, LAAV and LACV, as reflected by biases of 1.2, 0.9, 1.1, 0.3, 0.1,0.2 and 0.4 ml/m(2), respectively. The LAEF was minimally, but insignificantly underestimated as reflected by a bias of -0.6% (P = ns). The variability of the DSCT measurements was lower than that of the CMR values. DSCT provides highly reliable and reproducible measurements of the left atrial phasic volume and function in patients who are referred for coronary CT imaging.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessing the left atrial phasic volume and function with dual-source CT: comparison with 3T MRI

Wen

Zhang

et al. 2010

Int J Cardiovasc Imaging

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“…The greater left atrial diameter seems to reflect reduced left ventricular compliance, but in this respect, it has been previously reported that the left atrial diameter is associated with the prognosis of patients with dilated cardiomyopathy or hypertrophic cardiomyopathy. 13,14 In hypertensive patients, particularly hypertensive men, it has been reported that the left atrial diameter correlates with the degree of obesity and the left ventricular myocardial mass, 15 and serves as a predictor of the risk of stroke or atrial fibrillation. 16,17 However, in the present study, in which data at a single point in time were analyzed, it is not possible to discuss the relationship of these parameters to prognosis.…”

Section: Discussionmentioning

confidence: 99%

Aging and transmitral flow pattern in patients with systemic hypertension

et al. 2006

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“…It is associated with an increased risk of death in patients with dilated cardiomyopathy, LV dysfunction and postmyocardial infarction [33,88,89,90]. Interestingly, in a study of 273 patients with heart failure (age 62 ± 9 years and 13% female) who underwent echocardiographic analysis and exercise testing with VO 2 max determination, LA volume normalized for body surface area (LAV/BSA) was strongly associated with mortality (HR 1.027 and 95% CI 1.018-1.04; p < 0.0001).…”

Section: La: a Marker Of Adverse Prognosismentioning

confidence: 99%

The Left Atrium: From the Research Laboratory to the Clinic

et al. 2014

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Studies of left atrial (LA) function, until the latter part of the 20th century, were mostly limited to experimental animal models and to studies related to clinical research in the cardiac catheterization laboratory. For this reason, LA function has received considerably less attention than left ventricular (LV) functions, even though evidence suggests that LA myopathy and failure may exist as an isolated entity, precede and/or coexist with LV myopathy. The introduction of echocardiography and Doppler echocardiography in clinical practice has contributed significantly to our understanding of LA function and its interrelationships with the LV, aorta, pulmonary artery and other parts of the cardiovascular system. In addition, LA with the secretion of atrial natriuretic peptides is playing an important role in cardiovascular and neurohumoral homeostasis. Today, it is well known that LA structural and functional abnormalities that are present in many diseases and disorders constitute a powerful prognostic indicator. As technology (echocardiography, magnetic resonance imaging, computed tomography and others) continues to evolve, it is expected that, in the near future, LA structure and function will be routinely used as LV function is used today.

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Determinants and prognostic value of left atrial volume in patients with dilated cardiomyopathy

Abstract: In patients with DCM, LA volume is associated with LV remodeling, diastolic dysfunction, and the degree of MR. The maximal volume of the LA has an independent and incremental prognostic value, compared with all its determinants.

Cited by 320 publications

References 31 publications

Assessing the left atrial phasic volume and function with dual-source CT: comparison with 3T MRI

Assessing the left atrial phasic volume and function with dual-source CT: comparison with 3T MRI

Aging and transmitral flow pattern in patients with systemic hypertension

The Left Atrium: From the Research Laboratory to the Clinic

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