Determinants and distributions of plasma total homocysteine concentrations among school children in Taiwan

Chang, Jia-Kan; Chu, Nain-Feng; Shen, Muh-Han; Wu, Der-Min; Liang, Yuanyuan; Shieh, Shyh‐Ming

doi:10.1023/a:1022504602101

Cited by 14 publications

(15 citation statements)

References 25 publications

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“…This is consistent with studies of healthy population (Lim and Heo, 2002;Chang et al, 2003;Fakhrzadeh et al, 2006;Taskin et al, 2006). Higher homocysteine concentrations in men than in women may be explained by differences in muscle mass, hormone and vitamin status (Refsum et al, 2006).…”

Section: Conventional Cardiovascular Risk Factorssupporting

confidence: 90%

Total cardiovascular risk profile of Taiwanese vegetarians

Chen

Lin

et al. 2007

Eur J Clin Nutr

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Background: Although the health benefits of vegetarian diets have been well documented among Western population, there are geographic differences of vegetarian diets and the health benefits of the Taiwanese vegetarian diet have not been studied extensively. In addition to conventional risk factors, homocysteine and high-sensitivity C-reactive protein (hs-CRP) levels have been found to predict first atherothrombotic events. We undertook this study to examine the total risk profile of Taiwanese vegetarians. Methods: A total of 198 healthy subjects (99 vegetarians and 99 omnivores) were recruited. Fasting blood samples were analyzed for glucose, cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), white blood cell count, hs-CRP and homocysteine. Results: There was no significant difference in age, body mass index, blood glucose, white blood cell count, triglyceride and HDL-C between the two groups. The vegetarian group had significantly more females (65.7 vs 46.5%); lower body weight (58.66711.13 vs 62.88712.24 kg); shorter height (159.1477.88 vs 162.53 78.14 cm); lower total cholesterol (184.74733.23 vs 202.01741.05 mg/dl); and lower LDL-C (119.63731.59 vs 135.89739.50 mg/dl). Hs-CRP was significantly lower (0.1470.23 vs 0.2370.44 mg/dl, P ¼ 0.025), whereas homocysteine was significantly higher (10.9776.69 vs 8.4472.50 mmol/l, P ¼ 0.001) in vegetarians than omnivores. Conclusions: Taiwanese vegetarians have lower total cholesterol, LDL-C and hs-CRP levels, and higher homocysteine levels than omnivores. Owing to different predictive value of each risk factor, the Taiwanese vegetarians had a better cardiovascular risk profile than omnivores. Whether the Taiwanese vegetarian diet should be supplemented with vitamin B 12 to lower serum homocysteine level remains to be addressed.

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Section: Conventional Cardiovascular Risk Factorssupporting

confidence: 90%

Total cardiovascular risk profile of Taiwanese vegetarians

Chen

Lin

et al. 2007

Eur J Clin Nutr

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“…Cutoffs have varied from 8.3 to 13.75 μmol/L and differ by age and ethnicity [19,20,21,22]. In adults, hyperhomocysteinemia is commonly defined as concentrations greater than 12.0 μmol/L [23] or 15.0 μmol/L [24].…”

Section: Methodsmentioning

confidence: 99%

“…In adults, hyperhomocysteinemia is commonly defined as concentrations greater than 12.0 μmol/L [23] or 15.0 μmol/L [24]. Because there is no specific cut-off for defining high plasma homocysteine level in children, population-specific 85th percentile values may guide the definition of hyperhomocysteinemia for children [22]. In this analysis the 85th percentile of Hcy was 12.6 μmol/L, close to the widely accepted cutoff for hyperhomocysteinemia in adults, and used in previously published reports [22].…”

Section: Methodsmentioning

confidence: 99%

“…Because there is no specific cut-off for defining high plasma homocysteine level in children, population-specific 85th percentile values may guide the definition of hyperhomocysteinemia for children [22]. In this analysis the 85th percentile of Hcy was 12.6 μmol/L, close to the widely accepted cutoff for hyperhomocysteinemia in adults, and used in previously published reports [22]. Therefore, we chose a cutoff of 12.0 μmol/L to indicate hyperhomocysteinemia, despite lower cutoffs sometimes used in children, because it better reflected the risk of higher homocysteine observed in Asian populations [22] and because it is conventionally used.…”

Section: Methodsmentioning

confidence: 99%

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High Plasma Homocysteine Increases Risk of Metabolic Syndrome in 6 to 8 Year Old Children in Rural Nepal

Yakub

Schulze

Khatry³

et al. 2014

Nutrients

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Little attention has been given to the association of plasma homocysteine (Hcy) and metabolic syndrome (MetS) in children. We have evaluated the risk of MetS with plasma Hcy in a cohort of 6 to 8 year old rural Nepalese children, born to mothers who had participated in an antenatal micronutrient supplementation trial. We assessed Hcy in plasma from a random selection of n = 1000 children and determined the relationship of elevated Hcy (>12.0 μmol/L) to MetS (defined as the presence of any three of the following: abdominal adiposity (waist circumference ≥ 85th percentile of the study population), high plasma glucose (≥85th percentile), high systolic or diastolic blood pressure (≥90th percentile of reference population), triglyceride ≥ 1.7 mmol/L and high density lipoprotein < 0.9 mmol/L.) and its components. There was an increased risk of low high-density lipoproteins (HDL), [odds ratios (OR) = 1.77, 95% confidence intervals (CI) = 1.08–2.88; p = 0.020], high blood pressure [OR = 1.60, 95% CI = 1.10–2.46; p = 0.015] and high body mass index (BMI) [OR = 1.98, 95% CI = 1.33–2.96; p = 0.001] with elevated Hcy. We observed an increased risk of MetS (OR = 1.75, 95% CI = 1.06–2.90; p = 0.029) with elevated Hcy in age and gender-adjusted logistic regression models. High plasma Hcy is associated with increased risk of MetS and may have implications for chronic disease later in life.

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“…Chang et al (31) performed a randomized study in Taiwan and studied homocysteine, vitamin B12, and folic acid levels in 1234 children in the 12-15-year age group. Homocysteine levels were higher and folic acid and vitamin B12 levels were lower in males than in females, and an increase in homocysteine levels was observed with aging.…”

Section: Discussionmentioning

confidence: 99%

Homocysteine levels in normotensive children of hypertensive parents

Yıldırım¹,

Keles²,

Özdemir³

et al. 2015

Anatol J Cardiol

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Objective:There are several studies showing an association between an increase in the plasma levels of homocysteine and the pathogenesis of hypertension. In this study, we assessed normotensive children of hypertensive adult parents to determine whether there is any change in homocysteine levels prior to the onset of hypertension.Methods:A total of 79 normotensive children of essential hypertensive parents who were followed-up at the cardiology department and 72 healthy children of normotensive parents who presented to the department of pediatrics at our clinic with complaints such as nonspecific chest pain and innocent murmur were included in the study. The participants’ complete blood count and low-density lipoprotein, high-density lipoprotein, triglyceride, total cholesterol, folic acid, vitamin B12, and homocysteine levels were noted.Results:No statistically significant differences were noted between the two groups in terms of age, gender, height, weight, body mass index, or levels of fasting lipids, folic acid, and vitamin B12 (p>0.05). Although the mean systolic and diastolic blood pressures were within the normal limits in both groups, they were significantly higher in children with a family history of hypertension than in controls (p<0.05). Similarly, homocysteine levels of children with a family history of hypertension were significantly higher than those of controls (p<0.01).Conclusion:Homocysteine levels of normotensive children of hypertensive parents are elevated before they develop hypertension. Homocysteine levels may be predictive of the subsequent development of hypertension in normotensive children of hypertensive parents.

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Determinants and distributions of plasma total homocysteine concentrations among school children in Taiwan

Cited by 14 publications

References 25 publications

Total cardiovascular risk profile of Taiwanese vegetarians

Total cardiovascular risk profile of Taiwanese vegetarians

High Plasma Homocysteine Increases Risk of Metabolic Syndrome in 6 to 8 Year Old Children in Rural Nepal

Homocysteine levels in normotensive children of hypertensive parents

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