Determinantes da marcha independente na osteogênese imperfeita

Abstract

Objectives: Investigation of the locomotion process in patients with osteogenesis imperfecta (OI), and the factors that influence it, with special attention to clinical aspects relating to motor rehabilitation. Methods: a retrospective, cross-sectional study was carried out at the physical therapy outpatient clinic of the Instituto Fernandes Figueira. All patients with a clinical diagnosis of OI were included. Patients with other diseases, and those aged under two years, old were excluded. Epi-Info version 3.4 was used to construct the database, and SPSS version 15 for the statistical analysis. Results: The odds-ratio was used to measure the association between independent walking and clinical characteristics, adopting a level of significance of 5% for the analysis. Results: 69 patients were included. Of these, 43.5% were classified as OI type I; 37.7% as type III and 18.8% as type IV. 76.8% presented long bone deformities. A negative association was observed between hypotonia, number of fractures, and independent walking. A positive association was observed between independent walking and OI type I. Conclusions: physical therapy, as a complementary approach to orthopedics, and the administration of medications of the biophosphonates class, are of fundamental importance for the rehabilitation of motor capacity of individuals with OI. Level of Evidence, cross sectional.

Investigation on the Current Situation and Health-Related Quality of Life of Children and adolescents with OI in southwest China

“…A study found a negative correlation between HRQoL and number of fractures in OI patients [4] .Multiple fractures could lead to bone deformities, which would reduce the steep walking ability. A negative association was observed between hypotonia, number of fractures, and independent walking [25] . It always took more time for OI patients to regain walking ability after lower limb long-bone fracture.…”

Identifying the concepts in outcome measures of clinical trials on osteogenesis imperfecta using the International Classification of Functioning, Disability and Health - version for children and youth

“…The literature still lacks studies that investigate whether the benefits of this type of intervention in the structure and function of the body translates into benefits to other areas of functionality such as activity and participation of individuals with OI. 25 It is important to investigate these components, because there is no way to presume a direct relationship between a deficiency at the level of function and structure of the body and the limitations of daily life activity and restriction of social participation.…”