We present a new family {S n (x; q)} n≥0 of monic polynomials in x, orthogonal with respect to a Sobolev-type inner product related to the q-Hermite I orthogonal polynomials, involving a first-order q-derivative on a mass-point α ∈ R located out of the corresponding orthogonality interval [−1, 1], for some fixed real number q ∈ (0, 1). We present connection formulas, and the annihilation operator for this non-standard orthogonal polynomial family.