Determinación inmunohistoquímica de CD117/c-kit en el GIST (tumor estromal gastrointestinal)

Forcelledo, F. Fresno

doi:10.4321/s0378-48352004000400023

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…It consists of an extracellular ligand-binding domain, made up of 5 immuno-globulin-like repeats, a transmembrane hydrophobic region, and a cytoplasmic domain with tyrosine kinase (TK) activity. 3,22,27 Stem cell factor (SCF), the ligand of the KIT protein, is a cytokine that stimulates mast cell growth and differentiation. In the skin, SCF is produced by fibroblasts, keratinocytes, and endothelial cells.…”

Section: Introductionmentioning

confidence: 99%

Expression of KIT Receptor in Feline Cutaneous Mast Cell Tumors

et al. 2009

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Abstract. Twenty-seven feline cutaneous mast cell tumors (MCTs) were selected for this retrospective study. Samples were routinely processed and stained with hematoxylin and eosin (HE) and toluidine blue, and tumors were classified as well-differentiated (19/27), atypical or poorly granulate (7/27), and pleomorphic (1/27). Immunohistochemistry to detect KIT protein was performed on all samples. The immunoreactivity was recorded by distribution within the tumor, cellular location, and intensity. Well-differentiated MCTs were predominantly characterized by diffuse cytoplasmic (8/19) and membranous stain (7/19); a diffuse distribution of KIT positive cells was displayed in most of these tumors as well (15/19). Atypical MCTs showed diffuse distribution of labeled cells (4/7), and diffuse cytoplasm immunostaining was seen most (5/7). The pleomorphic MCT showed diffuse cytoplasmic KIT stain, with moderate labeling intensity, typically displaying focal distribution in deeper areas of the neoplasm. According to the results, there was no correlation between the type of MCTs and KIT expression, although the use of feline KIT immunohistochemistry could be useful to assess the mast cell origin.

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Section: Introductionmentioning

confidence: 99%