Determinação de tetraciclina em líquido sinovial de vacas com doença podal

Esteban, Cláudia; Rodrigues, Celso António; Nascimento, Elizabeth de Souza

doi:10.1590/s1516-93322007000200006

Cited by 4 publications

(2 citation statements)

References 11 publications

(12 reference statements)

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“…Coefficients of variation were <10% and 5%, for the smallest and largest concentrations, respectively. A recovery of 99.28% and accuracy of 98.78% were obtained (Esteban et al. , 2007).…”

Section: Methodsmentioning

confidence: 97%

Pharmacokinetics of tetracycline in plasma, synovial fluid and milk using single intravenous and single intravenous regional doses in dairy cattle with papillomatous digital dermatitis

Rodrigues

Hussni

Nascimento

et al. 2010

Vet Pharm & Therapeutics

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The purpose of this study was to compare the pharmacokinetics of tetracycline in plasma, synovial fluid, and milk following either a single systemic intravenous (i.v.) injection or a single i.v. regional antibiosis (IVRA) administration of tetracycline hydrochloride to dairy cattle with papillomatous digital dermatitis (PDD). To this end, plasma and synovial fluid tetracycline concentrations were compared with the minimal inhibitory concentration (MIC) values of the major bacteria, which are known to cause digital diseases and thus assess its efficacy in PDD. Residual tetracycline concentrations in milk from cows treated by both methods were also determined. Twelve Holstein cows with various stages of PDD were randomly assigned to two groups of six animals. Group 1 received a single systemic i.v. injection of 10 mg/kg of tetracycline hydrochloride. Group 2 received 1000 mg of tetracycline hydrochloride by IVRA of the affected limb. Blood, synovial fluid and milk samples were taken prior to tetracycline administration (time 0 control), and then at 22, 45 and 82 min, and 2, 3, 4, 6, 8, 12, 24, 48, 72, 96, and 120 h following drug administration. Tetracycline concentrations were determined by high-performance liquid chromatography. Mean tetracycline plasma and milk concentrations in Group 1 were higher than Group 2. The opposite was observed for synovial fluid concentrations. Group 2 synovial fluid concentrations were higher than the MIC value over 24 h for the bacteria most frequently responsible for claw disease. Compared with i.v. administration, IVRA administration of tetracycline produced very high synovial fluid and low plasma and milk concentrations.

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“…Coefficients of variation were <10% and 5%, for the smallest and largest concentrations, respectively. A recovery of 99.28% and accuracy of 98.78% were obtained (Esteban et al. , 2007).…”

Section: Methodsmentioning

confidence: 97%

Pharmacokinetics of tetracycline in plasma, synovial fluid and milk using single intravenous and single intravenous regional doses in dairy cattle with papillomatous digital dermatitis

Rodrigues

Hussni

Nascimento

et al. 2010

Vet Pharm & Therapeutics

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“…Reverse phase columns (C8 and C18) are commonly used for the chromatographic separation of these substances. The packing material allows tetracycline retention through the following mechanisms: ion pair formation, competition effects, active and inactive binding sites, ion exchange, interaction with silanol groups, among others [28,29].…”

Section: Analytical Techniquesmentioning

confidence: 99%

An overview of the main foodstuff sample preparation technologies for tetracycline residue determination

Pérez-Rodríguez

Pellerano

Pezza

et al. 2018

Talanta

137

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Tetracyclines are widely used for both the treatment and prevention of diseases in animals as well as for the promotion of rapid animal growth and weight gain. This practice may result in trace amounts of these drugs in products of animal origin, such as milk and eggs, posing serious risks to human health. The presence of tetracycline residues in foods can lead to the transmission of antibiotic-resistant pathogenic bacteria through the food chain. In order to ensure food safety and avoid exposure to these substances, national and international regulatory agencies have established tolerance levels for authorized veterinary drugs, including tetracycline antimicrobials. In view of that, numerous sensitive and specific methods have been developed for the quantification of these compounds in different food matrices. One will note, however, that the determination of trace residues in foods such as milk and eggs often requires extensive sample extraction and preparation prior to conducting instrumental analysis. Sample pretreatment is usually the most complicated step in the analytical process and covers both cleaning and pre-concentration. Optimal sample preparation can reduce analysis time and sources of error, enhance sensitivity, apart from enabling unequivocal identification, confirmation and quantification of target analytes. The development and implementation of more environmentally friendly analytical procedures, which involve the use of less hazardous solvents and smaller sample sizes compared to traditional methods, is a rapidly increasing trend in analytical chemistry. This review seeks to provide an updated overview of the main trends in sample preparation for the determination of tetracycline residues in foodstuffs. The applicability of several extraction and clean-up techniques employed in the analysis of foodstuffs, especially milk and egg samples, is also thoroughly discussed.

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Tetracyclines and an Overview of the Preconcentration/Extractions Method Based on Molecularly Imprinted Polymers

Rocha,

Tarley

2024

Molecularly Imprinted Polymers as Artificial Antibodies for the Environmental Health

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Determinação de tetraciclina em líquido sinovial de vacas com doença podal

Cited by 4 publications

References 11 publications

Pharmacokinetics of tetracycline in plasma, synovial fluid and milk using single intravenous and single intravenous regional doses in dairy cattle with papillomatous digital dermatitis

Pharmacokinetics of tetracycline in plasma, synovial fluid and milk using single intravenous and single intravenous regional doses in dairy cattle with papillomatous digital dermatitis

An overview of the main foodstuff sample preparation technologies for tetracycline residue determination

Tetracyclines and an Overview of the Preconcentration/Extractions Method Based on Molecularly Imprinted Polymers

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