Deterioration of naming nouns versus verbs in primary progressive aphasia

Hillis, Argye E.; Oh, Sang-Jin; Ken, Lynda

doi:10.1002/ana.10812

Cited by 183 publications

(117 citation statements)

References 61 publications

Supporting

Mentioning

107

Contrasting

Unclassified

Order By: Relevance

“…Future studies will also need to employ a broader, multimodal assessment of noun and verb processing. For example, the inclusion of both oral and written verb generation tasks might provide insights into the contributions of phonological versus orthographic processing to the verb-based semantic memory deficit in SCZ (e.g., Hillis, Oh, & Ken, 2004b). Similarly, the use of action and object naming (e.g., Kemmerer & Tranel, 2000) and concept recognition (Damasio et al, 2004) tests that are matched on item frequency and difficulty level are needed to determine the relative contributions of word search, retrieval and/or conceptual knowledge to the observed verb generation deficit in SCZ.…”

Section: Discussionmentioning

confidence: 99%

Preliminary evidence for impaired rapid verb generation in schizophrenia☆

et al. 2007

View full text Add to dashboard Cite

It has been hypothesized that nouns and verbs are processed within relatively separable semantic memory networks. Although abnormal semantic processing is a common feature of schizophreniaspectrum disorders, no prior studies have specifically examined the comparability of noun and verb generation deficits in schizophrenia. In the current study, verb (action), noun (animal), and letter (f) fluency performance was evaluated in 22 inpatients with schizophrenia and 27 healthy comparison subjects. On average, individuals with schizophrenia performed approximately one standard deviation below the healthy comparison subjects on action, animal, and letter fluency. Action fluency -but not letter or animal fluency -was moderately correlated with tests of working memory, response inhibition, semantic memory, and cognitive flexibility. Findings suggest that verb-and noun-based fluency deficits are of comparable severity in schizophrenia, but that the impairment in verb generation may be driven by different underlying cognitive mechanisms. Further, hypothesis-driven research on the nature and extent of verb network disruption in schizophrenia appears warranted. KeywordsSchizophrenia; Neuropsychology; Cognitive processes; Verbal fluency; Verbs Abnormalities within frontotemporal systems are hypothesized to play an important role in the etiology and expression of schizophrenia-spectrum disorders (SCZ). For example, in addition to ventriculomegaly, neuroimaging studies reveal altered structure and function of the thalamus, medial temporal lobes, and prefrontal cortex in individuals with SCZ (Davidson & Henrichs, 2003;Shenton, Dickey, Frumin, & McCarley, 2001). SCZ is also associated with impairments in many aspects of cognition, most notably episodic memory, language, attention, working memory, and executive functions (e.g., Fioravanti, Carlone, Vitale, Cinti, & Clare, 2005). Another common feature of SCZ is impairment in semantic memory, which is an aspect of declarative memory in which information related to facts, symbols, and concepts are * Address correspondence and reprint requests to: Steven Paul Woods, Psy.D., Department of Psychiatry (0847), University of California, San Diego, 150 West Washington Street, 2 nd floor, San Diego, CA, USA 92103. Electronic mail may be sent to spwoods@ucsd.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. processed (e.g., McKay, McKenna, Bentham, Mortimer, Holbery, & Hodges, 1996). It has been argued that the thought disorder evident in some individuals with SCZ, which is often expressed as disorganized speech (e.g., loose associations)...

show abstract

Section: Discussionmentioning

confidence: 99%

Preliminary evidence for impaired rapid verb generation in schizophrenia☆

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Oral production of overlearned sequences such as counting and repetition of phrasesismore fluent than spontaneous speech. The ability to name orally and write a pictured object's nameto confrontation is performed relatively well,although there may be difficulty naming with verbs 39 . There is relatively good comprehension of single words presented orally and in writing, although there may be difficulty with verb comprehension 38 .…”

Section: Speech and Language Deficits In Nappamentioning

confidence: 99%

The non-fluent/agrammatic variant of primary progressive aphasia

Grossman¹

2016

The Behavioral Neurology of Dementia

View full text Add to dashboard Cite

In an era of disease-modifying treatments, the non-fluent/agrammatic variant of primary progressive aphasia (naPPA) may help screen for a specific cause of neurodegenerative disease. However, there are controversies surrounding the identification of naPPA. This review describes the characteristic features associated with this discrete, young-onset neurodegenerative condition. Patients with naPPA have a distinct limitation in language emphasizingtheir poor grammatical comprehension and expression, as well as a disorder of speech sound production. Imaging studies associate an impairment of this uniquely human language capacity with disruption of a large-scale neural network centered in left inferior frontal and anterior-superior temporal regions. This corresponds to thepathologic burden of disease anatomically focused in left inferior frontal and anterior-superior temporal regions. A review of the histopathology underlying naPPA relates this condition to frontotemporal lobar degeneration spectrum pathology involving the microtubuleassociated protein tau in a majority of cases. While much work remains to be done, these observations point to unique clinical-pathological correlations that can advance care for an important class of diseases while supplementing our knowledge of human cognitive neuroscience.

show abstract

“…Hutchinson, 2003 ;Lucas, 2000). Des données récentes, essentiellement issues d'études neuropsychologiques (e.g., Berndt, Mitchum, Haendiges et Sandson, 1997 ;Bird, Howard et Franklin, 2000 ;Caramazza et Hillis, 1991 ;Hillis, Oh et Ken, 2004 ;Shapiro et Caramazza, 2003) et d'imagerie fonctionnelle (e.g., Grossman et al, 2002 ;Shapiro et al, 2005 ;Tranel, Martin, Damasio, Grabowski et Hichwa, 2005), semblent toutefois confirmer l'existence de représentations lexico-sémantiques distinctes pour les verbes et les noms, ou au moins de structures d'accès différentes pour les deux types de mots (voir Druks, 2002, pour une revue de question). D'autres chercheurs ont étudié l'acquisition des verbes et leur rôle diffé-rentiel dans le développement conceptuel et l'apprentissage du langage chez l'enfant (Imai, Haryu et Okada, 2005 ;Lidz et Gleitman, 2004 ;Tomasello, 1992).…”

Section: Introductionunclassified

Normes d’associations verbales pour 151 verbes d’action

Duscherer¹,

Mounoud²

2006

Année psy

View full text Add to dashboard Cite

RÉSUMÉCet article rapporte des normes d'associations verbales pour 151 verbes d'action français. Ces normes ont été recueillies par écrit au moyen d'une procédure d'association verbale libre, chaque mot ayant été présenté à 100 adultes francophones, âgés de 19 à 42 ans. La constitution de ces normes a comme but principal de remédier à l'absence de données psycholinguistiques pour les verbes alors qu'il y a abondance de données pour les noms. Ces normes pourraient être particulièrement utiles pour les études portant sur la spécificité des représentations lexico-sémantiques des verbes, sur les représentations et le traitement des actions, ou encore sur les pathologies associées, comme les aphasies, les anomies ou les apraxies. Word association norms for 151 action verbs ABSTRACTThis paper presents word association norms for 151 French action verbs. These norms were collected in writing through a free association procedure, each word being presented to 100 French-speaking adults, aged between 19 and 42 years. The main aim of this collection is to compensate for the lack of psycholinguistic norms for verbs compared to nouns. These norms are particularly useful for studies focussing on lexico-semantic representations of verbs, on action representations and on action processing, as well as for the assessment of the associated pathologies, like aphasia, anomia or apraxia. Our results suggest that primary association responses for verbs are mainly constituted by nouns as are primary association responses for nouns.

show abstract

Deterioration of naming nouns versus verbs in primary progressive aphasia

Cited by 183 publications

References 61 publications

Preliminary evidence for impaired rapid verb generation in schizophrenia☆

Preliminary evidence for impaired rapid verb generation in schizophrenia☆

The non-fluent/agrammatic variant of primary progressive aphasia

Normes d’associations verbales pour 151 verbes d’action

Contact Info

Product

Resources

About