Deterioration of murine embryonic fibroblasts and early embryos upon magnetic field deprivation

Osipenko, M. A.; Mezhevikina, L. M.; Krasts, I. V.; Yashin, V. A.; Novikov, V. V.; Фесенко, Е. Е.

doi:10.1134/s0006350908040167

Cited by 21 publications

(8 citation statements)

References 18 publications

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“…Even earlier before that discovery, there had been speculations that a long-term absence of the magnetic field could cause a serious change in their behaviour (cannibalism) and shorten their lifespan as well as bring about other physiological (infertility) and histological (diffuse tissue hyperplasia) dysfunctions (Dyke 1965;Conley 1969). Further studies also revealed that hypomagnetic conditions could inhibit early embryogenesis (Osipenko et al 2008a(Osipenko et al , 2008b and reproduction capacity (Fesenko et al 2010), impair learning abilities and memory of adult male mice (Wang et al 2003), and even inhibit stress-induced analgesia in male mice (Seppia et al 2000;Prato et al 2005). Other experiments demonstrated that even a short stay of living organisms in hypomagnetic conditions led to noticeable changes in enzymatic reactions and cell divisions of fibroblasts (Sosunov et al 1972) as well as animal behaviour, i.e.…”

Section: Studies On Life In Hypomagnetic Conditionsmentioning

confidence: 99%

How the Geomagnetic Field Influences Life on Earth – An Integrated Approach to Geomagnetobiology

Erdmann

Kmita

Kosicki

et al. 2021

Orig Life Evol Biosph

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Earth is one of the inner planets of the Solar System, but – unlike the others – it has an oxidising atmosphere, relatively stable temperature, and a constant geomagnetic field (GMF). The GMF does not only protect life on Earth against the solar wind and cosmic rays, but it also shields the atmosphere itself, thus creating relatively stable environmental conditions. What is more, the GMF could have influenced the origins of life: organisms from archaea to plants and animals may have been using the GMF as a source of spatial information since the very beginning. Although the GMF is constant, it does undergo various changes, some of which, e.g. a reversal of the poles, weaken the field significantly or even lead to its short-term disappearance. This may result in considerable climatic changes and an increased frequency of mutations caused by the solar wind and cosmic radiation. This review analyses data on the influence of the GMF on different aspects of life and it also presents current knowledge in the area. In conclusion, the GMF has a positive impact on living organisms, whereas a diminishing or disappearing GMF negatively affects living organisms. The influence of the GMF may also be an important factor determining both survival of terrestrial organisms outside Earth and the emergence of life on other planets.

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Section: Studies On Life In Hypomagnetic Conditionsmentioning

confidence: 99%

How the Geomagnetic Field Influences Life on Earth – An Integrated Approach to Geomagnetobiology

Erdmann

Kmita

Kosicki

et al. 2021

Orig Life Evol Biosph

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“…Abnormal morphogenesis, such as bi‐headedness and retarded larval development, has been observed in newt and Xenopus embryos growing in HMF [Asashima et al, 1991; Mo et al, 2012]. In addition to amphibians, in vitro studies indicated that the development of two‐cell murine embryos undergoes blastomere disorientation, permeabilization, and cytoskeletal alterations after 48 h of exposure [Osipenko et al, 2009]. In vivo studies revealed that the interaction between trophoblasts and the endometrium is impaired in pregnant mice at the zygote stage, resulting in the resorption of embryos in the uterus; thus, they completely lose their ability to bear offspring [Fesenko et al, 2010].…”

Section: The Biological Effects Of Hmfmentioning

confidence: 99%

Biological Effects of Hypomagnetic Field: Ground‐Based Data for Space Exploration

Zhang

Xue

Yang

et al. 2021

Bioelectromagnetics

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The future of mankind is tied to the exploration and eventual colonization of space. Currently, people have resided in orbit at a space station. In the future, we will have opportunities to stay on the moon, Mars, or in deeper space, where astronauts are exposed to the hypomagnetic field (HMF), which refers to an extremely weak magnetic field environment compared with the geomagnetic field. However, the potential risks of HMF exposure to human health are often overlooked. Here, we summarize the literature related to the biological effects of HMF and calculate the magnitude of the effect. Briefly, HMF impairs multiple animal systems, especially in the central nervous system. Additionally, HMF is a stress factor in plant growth and reproduction. Finally, HMF combined with other space environments, such as radiation and microgravity, can affect organisms. Further studies are required to explore (i) countermeasures to the adverse effects of HMF, (ii) combined effects of HMF with other factors, and (iii) the intensity‐effect relationship. © 2021 Bioelectromagnetics Society.

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“…Accumulated evidence has also revealed that HMF exposure impedes early embryonic and pup development of animals. For example, HMF damages the early development of rabbits leading to increased mortality [Kopanev et al, 1979], reduces the viability of Drosophila larvae after being injured [Portelli et al, 2012], affects the brood size and body length of daphnid neonates [Krylov et al, 2013], delays development time of planthopper eggs and larvae [Krylov et al, 2013; Wan et al, 2014, 2015], induces early developmental abnormalities in the newt Cynops pyrrhogaster [Asashima et al, 1991] and the frog Xenopus laevis [Mo et al, 2012], damages embryonic development of Japanese quail and the mollusk Planorbarius corneus [Trukhanov et al, 2014; Tsetlin et al, 2014], and even affects early embryogenesis and the reproduction capacity of mice with an increased rate of embryonic development termination and abortion [Osipenko et al, 2008; Fesenko et al, 2010].…”

Section: Effects Of Hmf Exposure On Animals or Cellsmentioning

confidence: 99%

Reactive Oxygen Species: Potential Regulatory Molecules in Response to Hypomagnetic Field Exposure

Zhang

Tian

2020

Bioelectromagnetics

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Organisms, including humans, could be exposed to hypomagnetic fields (HMFs, intensity <5 μT), e.g. in some artificially shielded magnetic environments and during deep-space flights. Previous studies have demonstrated that HMF exposure could have negative effects on the central nervous system and embryonic development in many animals. However, the underlying mechanisms remain unknown. Studies have revealed that HMFs affect cellular reactive oxygen species (ROS) levels and thereby alter physiological and biological processes in organisms. ROS, the major component of highly active free radicals, which are ubiquitous in biological systems, were hypothesized to be the candidate signaling molecules that regulate diverse physiological processes in response to changes in magnetic fields. Here, we summarize the recent advances in the study of HMF-induced negative effects on the central nervous system and early embryonic development in animals, focusing on cellular ROS and their role in response to HMFs. Furthermore, we discuss the potential mechanism through which HMFs regulate ROS levels in

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Deterioration of murine embryonic fibroblasts and early embryos upon magnetic field deprivation

Cited by 21 publications

References 18 publications

How the Geomagnetic Field Influences Life on Earth – An Integrated Approach to Geomagnetobiology

How the Geomagnetic Field Influences Life on Earth – An Integrated Approach to Geomagnetobiology

Biological Effects of Hypomagnetic Field: Ground‐Based Data for Space Exploration

Reactive Oxygen Species: Potential Regulatory Molecules in Response to Hypomagnetic Field Exposure

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