Deterioration of Limb Muscle Function during Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Abdulai, Raolat M.; Jensen, Tina Jellesmark; Patel, Naimish; Polkey, Michael I.; Jansson, Paul; Celli, Bartolomé R.; Rennard, Stephen I.

doi:10.1164/rccm.201703-0615ci

Cited by 70 publications

(53 citation statements)

References 140 publications

(141 reference statements)

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“…Irrespective of the method used to assess muscle mass [8], it is well known that patients with COPD suffer from loss of muscle mass . Indeed, loss of muscle mass and muscle strength can be greater in patients with moderate-to severe COPD [7,30] or during acute COPD exacerbations [31], especially loss of muscle from the lower limbs [6,7,32].…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia in COPD: a systematic review and meta-analysis

et al. 2019

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COPD is associated with a progressive loss of muscle mass and function. However, there is an unmet need to define and standardise methods to estimate the prevalence of sarcopenia in COPD patients.We performed a systematic review and meta-analysis of the prevalence of this extrapulmonary manifestation in COPD patients. We searched Embase, Medline (Ovid), CINAHL (EBSCO), Web of Science, Scopus and Google Scholar for studies published up to January 17, 2019, assessing sarcopenia in COPD patients based on low muscle mass and decreased muscle function. Interventional studies, in vitro experiments, protocols or reviews and meta-analyses were excluded. We estimated heterogeneity (I2) and assessed significance (Q) using a Chi-squared test for estimates obtained from random-effects models.4465 articles were initially identified. After removing the duplicates and applying the selection criteria, we reviewed 62 full-text articles. Finally, 10 articles (n=2565 COPD patients) were included in this systematic review and meta-analyses. Overall, the prevalence of sarcopenia in patients with COPD was 21.6% (95% CI 14.6–30.9%, I2=94%), ranging from 8% in population-based to 21% in clinic-based studies, and 63% in COPD patients residing in nursing homes.Sarcopenia is frequently observed in COPD patients, with varying prevalence across population settings. Sarcopenia in COPD should be assessed using standardised tests and cut-off points from sarcopenia consensus criteria for clinical practice and international comparisons.

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Section: Introductionmentioning

confidence: 99%

Sarcopenia in COPD: a systematic review and meta-analysis

et al. 2019

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“…Capillarization and myofiber mitochondrial oxidative capacity of muscle fibers and motor units are positively correlated with their fatigue resistance (Degens and Veerkamp, 1994). Thus, in addition to reduced local tissue oxidative capacity, capillary rarefaction occurring in disuse may also lead to (i) lower fatigue resistance (Degens and Alway, 2006;Hendrickse and Degens, 2019), (ii) abnormal intramuscular fat infiltration (Pagano et al, 2018), and (iii) exacerbation of tissue inflammation and damage, as for example observed with chronic obstructive pulmonary disease (COPD) in the hypoactive patient (Abdulai et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Reactive Jumps Preserve Skeletal Muscle Structure, Phenotype, and Myofiber Oxidative Capacity in Bed Rest

et al. 2020

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Identification of countermeasures able to prevent disuse-induced muscle wasting is crucial to increase performance of crew members during space flight as well as ameliorate patient's clinical outcome after long immobilization periods. We report on the outcome of short but high-impact reactive jumps (JUMP) as countermeasure during 60 days of 6 • head-down tilt (HDT) bed rest on myofiber size, type composition, capillarization, and oxidative capacity in tissue biopsies (pre/post/recovery) from the knee extensor vastus lateralis (VL) and deep calf soleus (SOL) muscle of 22 healthy male participants (Reactive jumps in a sledge, RSL-study 2015-2016, DLR:envihab, Cologne). Bed rest induced a slow-to-fast myofiber shift (type I ->II) with an increased prevalence of hybrid fibers in SOL after bed rest without jumps (control, CTRL, p = 0.016). In SOL, JUMP countermeasure in bed rest prevented both fast and slow myofiber cross-sectional area (CSA) decrements (p = 0.005) in CTRL group. In VL, bed rest only induced capillary rarefaction, as reflected by the decrease in local capillaryto-fiber ratio (LCFR) for both type II (pre vs. post/R + 10, p = 0.028/0.028) and type I myofibers (pre vs. R + 10, p = 0.012), which was not seen in the JUMP group. VO 2maxFiber (pL × mm −1 × min −1 ) calculated from succinate dehydrogenase (SDH)stained cryosections (OD 660 nm ) showed no significant differences between groups. High-impact jump training in bed rest did not prevent disuse-induced myofiber atrophy in VL, mitigated phenotype transition (type I ->II) in SOL, and attenuated capillary rarefaction in the prime knee extensor VL however with little impact on oxidative capacity changes.

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“…Both hypo-and hypercapnia are associated with increased mortality in COPD patients with hypocapnia hypothesized to lead to respiratory muscle fatigue and subsequent failure (34). Patients often experience pulmonary cachexia with hypercapnia associated with deterioration of muscle function (35). Pulmonary hypertension (PH) is prevalent in advanced disease and is associated with increased mortality (36).…”

Section: Chronic Obstructive Pulmonary Diseasementioning

confidence: 99%

Contemporary approaches in the use of extracorporeal membrane oxygenation to support patients waiting for lung transplantation

Keller

2020

Ann Cardiothorac Surg

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The introduction of the lung allocation score in 2005 prioritized patients with decreased transplant-free survival as the recipients of donor organs and effectively increased the number of critically-ill patients with end-stage lung disease waiting for transplantation. This change presented transplant programs with the challenge of how to both extend the lives of critically-ill, end-stage lung disease patients waiting for donor organs and maintain patient vitality to survival through the rigors of surgery and post-transplant recovery. Motivated by the dismal outcomes of patients maintained on mechanical ventilation pre-transplant, transplant centers increasingly deploy extracorporeal membrane oxygenation (ECMO) as a means of supporting patients with advanced disease as a bridge to successful lung transplantation. ECMO is an extracorporeal gas exchange device providing delivery of oxygen and removal of carbon dioxide from blood passed through the circuit. The specific cannulation strategy determines whether ECMO provides primarily respiratory or circulatory support. The cannulation approach is tailored to the specific physiological manifestations of the pre-lung transplant candidate's disease process. For patients with profound hypoxic respiratory failure, a cannulation strategy that captures a large fraction of the venous return is required to maintain adequate support whereas lower circuit flows are sufficient for patients with predominantly hypercapnic respiratory failure. Improving outcomes and increasing experience with ECMO is motivating transplant centers to initiate support before patients require mechanical ventilation. Awake cannulation is increasingly common and is used to avoid the complications associated with intubation in advanced lung failure. Determining criteria for initiation of support and identifying the optimal approach to support patients with right heart failure in need of circulatory support are avenues of active investigation. Use of ECMO and other forms of extracorporeal support are rapidly becoming a mainstay in the care of the prelung transplant patient with advanced disease.

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Deterioration of Limb Muscle Function during Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Cited by 70 publications

References 140 publications

Sarcopenia in COPD: a systematic review and meta-analysis

Sarcopenia in COPD: a systematic review and meta-analysis

Reactive Jumps Preserve Skeletal Muscle Structure, Phenotype, and Myofiber Oxidative Capacity in Bed Rest

Contemporary approaches in the use of extracorporeal membrane oxygenation to support patients waiting for lung transplantation

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