Deteriorating tactile sensation in patients with hand syndromes associated with diabetes: A two-year observational study

Redmond, Christine L.; Bain, Gregory I.; Laslett, Laura L; McNeil, Julian

doi:10.1016/j.jdiacomp.2012.04.009

Cited by 16 publications

(14 citation statements)

References 51 publications

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“…Savas et al noted similar decreases in grip strength (16%) and key pinch strength (9%) in patients with diabetes compared with those without diabetes [17]. Significant differences in grip strength and sensation in the hand have also been recorded in other studies [11,18–20,35]. Individuals with diminished protective sensation may have decreased hand function, leading to difficulty in manipulation of small objects and a tendency to drop objects [11,32].…”

Section: Discussionmentioning

confidence: 61%

“…Light touch perception was measured in the peripheral nerve supply of the hand using Semmes Weinstein monofilaments (Tactile sensory evaluator, Baseline, Elmsford, NY, USA) [20,32,33]. Filaments ranging from 2.83 to 6.65 (0.07 to 330 g force) were applied until they bent and #6.65 was applied just to bending.…”

Section: Methodsmentioning

confidence: 99%

“…Studies have examined shoulder [7,14–16] or hand [11,17–20] impairments in patients with diabetes, but the combined influence of shoulder and hand impairments on upper extremity pain and disability has not, to the authors’ knowledge, been studied to date. A few studies have examined limited joint mobility of the shoulder and reported differences in range of motion (ROM) between patients with diabetes and those without diabetes [7,14–16], but studies of shoulder strength and upper extremity function are lacking.…”

Section: Introductionmentioning

confidence: 99%

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Upper extremity impairments, pain and disability in patients with diabetes mellitus

et al. 2015

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Objectives To determine the severity of, and relationships between, upper extremity impairments, pain and disability in patients with diabetes mellitus, and to compare upper extremity impairments in patients with diabetes with non-diabetic controls. Design Case–control, cross-sectional design. Setting University-based, outpatient diabetes centre and physical therapy research clinic. Participants Two hundred and thirty-six patients with diabetes attending an outpatient diabetes clinic completed the Shoulder Pain and Disability Index (SPADI) questionnaire. A detailed shoulder and hand examination was conducted on a subgroup of 29 volunteers with type 2 diabetes, and 27 controls matched for age, sex and body mass index. Interventions None. Main outcome measures SPADI score, passive shoulder range of motion (ROM) and strength, grip strength, hand sensation, dexterity and limited joint mobility of the hand. Results Sixty-three percent (149/236) of patients with diabetes reported shoulder pain and/or disability [median SPADI score 10.0 (interquartile range 0.0 to 39.6)]. Compared with the control group, the subgroup of patients with diabetes had substantial reductions in shoulder ROM, shoulder muscle strength, grip and key pinch strength (P<0.05). Patients with diabetes had a greater prevalence of decreased sensation (26/27 vs 14/27) and limited joint mobility of the hand (17/27 vs 4/27) compared with the control group. Total SPADI score was negatively correlated (P<0.05) with shoulder ROM (r= −0.42 to −0.74) and strength measures (r= −0.44 to −0.63) in patients with diabetes. Conclusions Upper extremity impairments in this sample of patients with diabetes were common, severe and related to complaints of pain and disability. Additional research is needed to understand the unique reasons for upper extremity problems in patients with diabetes, and to identify preventative treatments.

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Section: Discussionmentioning

confidence: 61%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Upper extremity impairments, pain and disability in patients with diabetes mellitus

et al. 2015

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“…A study of tactile sensation showed that it was reduced during the 2-year follow-up period in Ty2DM patients. Tactile dysfunction detected by clinical examination, however, was associated with attenuated metabolic control (Redmond et al 2012).…”

Section: Sensory Decline In Diabetesmentioning

confidence: 99%

Dysfunctional Sensory Modalities, Locus Coeruleus, and Basal Forebrain: Early Determinants that Promote Neuropathogenesis of Cognitive and Memory Decline and Alzheimer’s Disease

Daulatzai

2016

Neurotox Res

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Sporadic Alzheimer's disease (AD) is a devastating neurodegenerative disorder. It is essential to unravel its etiology and pathogenesis. This should enable us to study the presymptomatic stages of the disease and to analyze and reverse the antemortem behavioral, memory, and cognitive dysfunction. Prima facie, an ongoing chronic vulnerability involving neural insult may lead normal elderly to mild cognitive impairment (MCI) and then to AD. Development of effective preventive and therapeutic strategies to thwart the disease pathology obviously requires a thorough delineation of underlying disruptive neuropathological processes. Our sensory capacity for touch, smell, taste, hearing, and vision declines with advancing age. Declines in different sensory attributes are considered here to be the primary "first-tier pathologies." Olfactory loss is among the first clinical signs of neurodegenerative diseases including AD and Parkinson's disease (PD). Sensory dysfunction in the aged promotes pathological disturbances in the locus coeruleus, basal forebrain, entorhinal cortex, hippocampus, and several key areas of neocortex and brainstem. Hence, sensory dysfunction is the pivotal factor that may upregulate cognitive and memory dysfunction. The age-related constellation of comorbid pathological factors may include apolipoprotein E (APOE) genotype, obesity, diabetes, hypertension, alcohol abuse, head trauma, and obstructive sleep apnea. The concepts and trajectories delineated here are the dynamic pillars of the current hypothesis presented-it postulates that the sensory decline, in conjunction with the above pathologies, is crucial in triggering neurodegeneration and promoting cognitive/memory dysfunction in aging and AD. The application of this thesis can be important in formulating new multifactorial preventive and treatment strategies (suggested here) in order to attenuate cognitive and memory decline and ameliorate pathological dysfunction in aging, MCI, and AD.

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“…Recently, sensorimotor disturbances in diabetic hands were reported to be an important factor in compromising the hand functions of such patients [12]. Redmond et al reported that the tactile sensation in diabetic hands was abnormal with reduced function over a two-year follow-up period [13]. Some studies have also reported abnormal neurophysiological findings in the median nerves of diabetic patients [14], [15].…”

Section: Introductionmentioning

confidence: 99%

How the Impact of Median Neuropathy on Sensorimotor Control Capability of Hands for Diabetes: An Achievable Assessment from Functional Perspectives

et al. 2014

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To comprehend the sensorimotor control ability in diabetic hands, this study investigated the sensation, motor function and precision pinch performances derived from a pinch-holding-up activity (PHUA) test of the hands of diabetic patients and healthy subjects. The precision, sensitivity and specificity of the PHUA test in the measurements of diabetic patients were also analyzed. We hypothesized that the diabetic hands would have impacts on the sensorimotor functions of the hand performances under functionally quantitative measurements. One hundred and fifty-nine patients with clinically defined diabetes mellitus (DM) and 95 age- and gender-matched healthy controls were included. Semmes-Weinstein monofilament (SWM), static and moving two-point discrimination (S2PD and M2PD), maximal pinch strength and precision pinch performance tests were conducted to evaluate the sensation, motor and sensorimotor status of the recruited hands. The results showed that there were significant differences (all p<0.05) in SWM, S2PD, M2PD and maximum pinch strength between the DM and control groups. A higher force ratio in the DM patients than in the controls (p<0.001) revealed a poor ability of pinch force adjustment in the DM patients. The percentage of maximal pinch strength was also significantly different (p<0.001) between the DM and control groups. The sensitivity, specificity and area under the receiver operating characteristic curve were 0.85, 0.51, and 0.724, respectively, for the PHUA test. Statistically significant degradations in sensory and motor functions and sensorimotor control ability were observed in the hands of the diabetic patients. The PHUA test could be feasibly used as a clinical tool to determine the sensorimotor function of the hands of diabetic patients from a functional perspective.

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Deteriorating tactile sensation in patients with hand syndromes associated with diabetes: A two-year observational study

Cited by 16 publications

References 51 publications

Upper extremity impairments, pain and disability in patients with diabetes mellitus

Upper extremity impairments, pain and disability in patients with diabetes mellitus

Dysfunctional Sensory Modalities, Locus Coeruleus, and Basal Forebrain: Early Determinants that Promote Neuropathogenesis of Cognitive and Memory Decline and Alzheimer’s Disease

How the Impact of Median Neuropathy on Sensorimotor Control Capability of Hands for Diabetes: An Achievable Assessment from Functional Perspectives

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