Detection rate of FNA cytology in medullary thyroid carcinoma: a meta‐analysis

Abstract

The presented meta-analysis demonstrates that FNAC is able to detect approximately one-half of MTC lesions. These findings suggest that other techniques may be needed in combination with FNAC to diagnose MTC and avoid false negative results.

Fine-needle aspiration cytology for medullary thyroid carcinoma: a single institutional experience in Japan

“…According to a meta-analysis by Trimboli et al, the detection rate of FNAC in patients with MTC ranged from 12.5% to 88.2%, with a pooled estimate of 56.4% [14]. In our study, the detection and diagnosis of MTC were achieved in 76.5% and 70.6% of cases, respectively.…”

“…In general, thyroid nodules discovered by ultrasonography or palpation undergo FNAC for diagnosis and 94 (46.8%) were other lesions (Table 3), including PTC (46), adenomatous nodules (22), follicular neoplasms (14), chronic thyroiditis (4), poorly differentiated carcinomas (3), Graves' disease (1), hyalinizing trabecular tumor (1), carcinoma showing thymus-like differentiation (1), columnar cell carcinoma (1), and well-differentiated neoplasm of uncertain malignant potential (1). The calcitonin levels ranged from 14 pg/ mL to 6,600,000 pg/mL in the MTC nodules.…”

Ultrasound features of medullary thyroid carcinoma correlate with cancer aggressiveness: a retrospective multicenter study

“…This finding extends the conclusions of all the above studies [6][7][8][9][10][11][12] and indirectly prompts to use calcitonin measurement in the initial evaluation of thyroid nodules [2,4]. In general, the possibility to submit to FNA all nodules with a significant size (i.e.…”

“…Fine needle aspiration (FNA) of thyroid nodules has several pitfalls for this histologic type. The cytologic examination can diagnose MTC with classical presentation, and the detection rate was reported of 56% in a recent meta-analysis [2]. The routine measurement of serum calcitonin is still a matter of debate and ultrasonography (US) does not achieve high reliability rates [3].…”

Measurement of thyroglobulin, calcitonin, and PTH in FNA washout fluids

“…This approach was based on the several limits of cytology in detecting MTC reported in the literature [7]. In this context, a higher accuracy of serum CT with respect to cytology was proven [8], and poor sensitivity of cytology (i.e.…”