Detection rate of prostate cancer following biopsy among the northern Han Chinese population: a single-center retrospective study of 1022 cases

Abstract

BackgroundProstate cancer is known to have ethnic and regional differences. The study aimed to clinically evaluate the detection rate of prostate cancer on transrectal ultrasonography (TRUS)-guided prostate biopsy and analyze its characteristics among the northern Han Chinese population at a single center.MethodsBetween October 2009 and September 2016, a total of 1027 Chinese men, who had undergone TRUS-guided prostate biopsy at Qingdao Municipal Hospital, were retrospectively analyzed. Prostate biopsies were performed in the case of an abnormally elevated serum PSA level, and/or abnormal digital rectal examination (DRE) findings, and/or suspicious prostatic imaging findings.ResultsOf the 1022 men enrolled in the analysis, 438 patients (42.8%) were diagnosed with prostate adenocarcinoma histologically. When serum PSA levels were divided into five subgroups (less than 4.0, 4.0 to 10.0, 10.0 to 20.0, 20.0 to 100.0, and ≥ 100.0 ng/ml), the detection rates of prostate cancer were 12.4, 15.9, 34.1, 66.2, and 93.8%, respectively. With serum PSA levels of 4.0 to 10.0 ng/ml, the cancer detection rates for a normal DRE and a suspect DRE finding were 13.5 and 58.2%, respectively. Accordingly, the cancer detection rates for a normal imaging and a suspect imaging finding were 13.5 and 58.2%, respectively. Besides, a large proportion of the patients were in the clinically advanced stage.ConclusionsThe present study data reported a relatively higher prostate cancer detection rate of 42.8% and that the majority of the patients presented with clinically advanced prostate cancers within a local clinical urologic practice. An early detection and screening program for prostate cancer is of great need to reduce the burden from this disease among the northern Han Chinese population.

Outcomes of standard 12-core transrectal ultrasound-guided prostate biopsy in biopsy naive Indian men -single center experience

“…Similar to our study the significant number of patients had advanced cancer at initial diagnosis. [ 11 ] Our study and study by Gupta et al show a similar cancer detection rate and is comparable with the western and Asian literature[ 6 ] [ Table 4 ].…”

Putative Risk Factors of Prostate Cancer in Unscreened Ghanaian Men

“…The higher threshold was set to offset the biases that may be associated with PSA values. PSA values above 10 ng/ml have high speci city in prostate cancer diagnosis [16,17].…”

Detection rate of prostate cancer following 12-core extended biopsy in a Semi-urban Nigerian Tertiary Hospital

“…[ 11 12 13 ] The extended 12-core biopsy template increases the detection rate of prostate cancer and decreases the probability of repeat biopsy when compared to the sextant protocol. [ 14 ] Jia et al [ 15 ] in a study done among the Han people of China, reported prostate cancer detection rate of 42.8% following a 10-core (plus an additional core in each suspicious area) biopsy protocol. Furthermore, Ojewola[ 16 ] in South-western Nigeria, reported an overall cancer detection by the extended technique as 48.8%.…”