Detection rate and factors predictive the presence of prostate cancer in patients undergoing ultrasonography‐guided transperineal saturation biopsies of the prostate

Novara, Giacomo; Boscolo‐Berto, Rafael; Lamon, Claudio; Fracalanza, S.; Gardiman, Marina Paola; Artibani, Walter; Ficarra, Vincenzo

doi:10.1111/j.1464-410x.2009.08954.x

Cited by 26 publications

(12 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies have shown that prostate volume is a relevant variable for the detection of PC [32,33,34]. Uzzo et al [35] have reported a PC detection rate of 23% in prostates ≥50 ml and 38% in prostates <50 ml.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Different Systematic Prostate Biopsy Methods in the Detection of Prostate Cancer with Ultrasonographic Hypoechoic Lesions - A Comparative Study

Yao²,

Wu³

et al. 2015

Urol Int

View full text Add to dashboard Cite

Objective: To assess if a less extended biopsy in the transperineal approach is sufficient for detection of prostate cancer (PC) in patients with hypoechoic lesions. Methods: This was a prospective study of 167 consecutive patients with prostate hypoechoic lesion and who underwent transperineal ultrasound (TPUS)-guided 12-core and hypoechoic lesion core biopsy between January 2012 and February 2013. Results: PC was detected in 64.1% (107/167) of patients. The PC detection rate of the 12-core prostate biopsy scheme was the highest, but when including the hypoechoic lesion core, there was no difference between the 6- and 12-core schemes (all p > 0.05), irrespective of prostate volume or prostate-specific antigen levels (all p > 0.05). Conclusions: A more limited biopsy scheme could be sufficient for the detection of PC if the hypoechoic lesion is sampled.

show abstract

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Different Systematic Prostate Biopsy Methods in the Detection of Prostate Cancer with Ultrasonographic Hypoechoic Lesions - A Comparative Study

Yao²,

Wu³

et al. 2015

Urol Int

View full text Add to dashboard Cite

show abstract

“…Novara et al. [6] summarised published reports and showed that the cancer detection rate was similar among different series and approaches. The overall detection rate ranged from 14 to 45% for the transrectal approach and from 23 to 42% for the transperineal approach in men without and up to three previous negative biopsy series.…”

Section: Introductionmentioning

confidence: 97%

High detection rate of significant prostate tumours in anterior zones using transperineal ultrasound‐guided template saturation biopsy

et al. 2012

View full text Add to dashboard Cite

What ' s known on the subject? and What does the study add? Men with persistent suspicion for prostate cancer after previous negative standard transrectal biopsy series are offered saturation biopsy either transrectally or transperineally to increase cancer detection rate.A high-risk group of men with at least two previous negative transrectal biopsies underwent transperineal template-guided saturation biopsy. Prostate cancer was detected in 26%, predominantly in the anterior zones. PSA velocity or doubling time were the most powerful factors to predict cancer. OBJECTIVE• To evaluate the detection rate and the regional location of prostate cancer in men undergoing transperineal template-guided saturation biopsy (TTSB). PATIENTS AND METHODS• In all, 92 consecutive men with at least two previous negative transrectal biopsy series who underwent a multiple-core prostate TTSB at our centre were included in the study.• Univariable and multivariable logistic regression analyses were used to address the relationship between parameters before TTSB and prostate cancer-detection rate.• Covariates consisted of age at biopsy, free and total prostate-specifi c antigen (PSA), prostate volume, digital rectal examination fi ndings, histological fi ndings on previous biopsy, PSA velocity (PSAV), PSA-doubling time (PSADT) and the number of previous negative biopsy sets. RESULTS• Prostate cancer was diagnosed in 26% of the men.• A median of 30 cores was taken by TTSB.• Adenocarcinoma in > 2 cores was detected in 58.5% and Gleason score ≥ 7 was detected in 46% of the diagnosed men.• Most of the tumours (83.3%) were found in the anterior zones of the gland, with a signifi cantly higher number of positive cores vs the posterior zones (mean 4.9 vs 1.5, P = 0.015).• PSADT and PSAV were the only independent predictors of prostate cancer detection at multivariate analyses with odds ratios of 0.71 ( P = 0.014) and 1.58 ( P = 0.025), respectively. CONCLUSIONS• TTSB has a high prostate cancerdetection rate, especially in the anterior zones.• Men after at least two previous negative transrectal biopsy series and persistent suspicion of prostate cancer, as evidenced by rapid PSA dynamics, should be offered TTSB.

show abstract

“…There has been no general agreement regarding the number of cores and the optimal approach. In addition, we noticed that there was no specific relationship between the method used and the cancer detection rates (4,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) (Table IV).…”

Section: Discussionmentioning

confidence: 99%

Comparison Between a Combined Transrectal and Transperineal Approach and a Transrectal Approach for Prostate Rebiopsy

Shida

Hakariya

Takehara

et al. 2016

View full text Add to dashboard Cite

Abstract. Aim: To evaluate whether a combination method involving the transrectal (TR) and transperineal (TP)approach 1, 2, 3, 4 and 5 were 49.2% (551/1,119), 34.7% (75/216), 33.3% (20/60), 26.7% (4/15) Transrectal ultrasound (TRUS)-guided biopsy has been recognized as the standard method for confirming a prostate cancer diagnosis worldwide. The utility of magnetic resonance (MR)-guided biopsy has been indicated in recent reports (1, 2). We agree with the opinion, however, that discussion on TRUS biopsy is still important due to its cost and equipment. In short, we think that MR-guided biopsy is often difficult in developing countries. After the initial introduction of the sextant prostate biopsy technique proposed by Hodge (3), the TRUS-guided biopsy technique has evolved with the introduction of extended 10-to 12-core biopsy and, subsequently, to over 20-core saturation biopsy strategies to minimize the sampling error and improve the accuracy of prostate cancer detection (4). However, it is well-recognized that even the standard 12-core TRUS-guided biopsy can miss up to 30% of cancers (5). TRUS-guided biopsy predominantly targets the lateral and posterior peripheral gland and can miss anteriorly located cancers. Therefore, several studies have focused on methods for anterior and apical biopsies.Transperineal (TP) biopsy of the prostate is an alternative approach that is less frequently performed. Kakehi et al. (6) reviewed 212,065 biopsies carried out at 548 institutions during the period between 2004 and 2006 in Japan. Of the 212,065 biopsies, 76% were carried out using the transrectal (TR) approach, 23% using the TP approach and only 1% using the combined methods of TR and TP (TR+TP). Ong et al. (7) reported that TP biopsy accounted for <0.5% of all prostate biopsies performed in Australia in 2007. However, there has been increasing interest in TP biopsy in recent 4685This article is freely accessible online.

show abstract

Detection rate and factors predictive the presence of prostate cancer in patients undergoing ultrasonography‐guided transperineal saturation biopsies of the prostate

Cited by 26 publications

References 23 publications

Diagnostic Value of Different Systematic Prostate Biopsy Methods in the Detection of Prostate Cancer with Ultrasonographic Hypoechoic Lesions - A Comparative Study

Diagnostic Value of Different Systematic Prostate Biopsy Methods in the Detection of Prostate Cancer with Ultrasonographic Hypoechoic Lesions - A Comparative Study

High detection rate of significant prostate tumours in anterior zones using transperineal ultrasound‐guided template saturation biopsy

Comparison Between a Combined Transrectal and Transperineal Approach and a Transrectal Approach for Prostate Rebiopsy

Contact Info

Product

Resources

About