Detection of vulnerable plaque in a murine model of atherosclerosis with optical coherence tomography

Çilingiroğlu, Mehmet; Oh, Jung Hwan; Sugunan, Binu; Kemp, Nate J.; Kim, Jeehyun; Lee, Shuko; Zaatari, Haitham N.; Escobedo, Daniel; Thomsen, Sharon; Milner, Thomas E.; Feldman, Marc D.

doi:10.1002/ccd.20717

Cited by 62 publications

(39 citation statements)

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“…The OCT appearance of lipid, smooth muscle cell, fibrotic regions, and microcalcifications reported in this study agrees with previous reports on these components studied in vessel wall imaging [10,11,18]. The identification of lipid by OCT was, however, often obscured due to its colocalization with microcalcifications in the CTO.…”

Section: Identification Of Specific Tissue Characteristicssupporting

confidence: 91%

Ex vivo imaging of chronic total occlusions using forward‐looking optical coherence tomography

et al. 2006

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Background and ObjectivesPercutaneous coronary interventions (PCI) of chronic total occlusions (CTOs) of arteries are more challenging lesions to treat with angioplasty and stenting than stenotic vessels due primarily to the difficulty in guiding the wire across the lesion. Angiography alone is unable to differentiate between the occluded lumen and the vessel wall and to characterize the content of the occlusion. New technologies to aid in interventional guidance are therefore highly desirable. We sought to evaluate tissue characterization in arterial (CTOs) by imaging ex vivo peripheral arterial samples with optical coherence tomography (OCT).Study Design/Materials and MethodsEx vivo arterialsamples were obtained from patients undergoing peripheral limb amputation. Samples were imaged in an enface orientation using an OCT system, enabling sequential acquisition of longitudinal images and volumetric reconstruction of cross‐sectional views of theoccluded arteries. Histology was performed for comparison.ResultsOCT imaging reliably differentiated between the occluded lumen and the underlying arterial wall in peripheral CTOs. OCT correctly identified tissue composition within the CTO, such as the presence of collagen and calcium and was also able to identify intraluminal microchannels.ConclusionsOCT imaging of CTO anatomy and tissue characteristics may potentially lead to substantial improvements in PCI interventions by providing novel guiding capabilities. Lasers Surg. Med. © 2006 Wiley‐Liss, Inc.

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Section: Identification Of Specific Tissue Characteristicssupporting

confidence: 91%

Ex vivo imaging of chronic total occlusions using forward‐looking optical coherence tomography

et al. 2006

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“…The present study suggests that the primary prevention of atherosclerosis-related diseases in humans can be affected therapeutically through an early implementation of a balanced program of moderate PE and appropriate MT with antioxidants plus L-arginine. To this regard, a very recent study (46) shows the feasibility of optical coherence tomography to identify the components of vulnerable plaques in a murine model of human atherosclerosis. This protocol holds promise for the identification of features defining vulnerable plaque including fibrous cap thickness, lipid core size, and the percentage of lipid content.…”

Section: Discussionmentioning

confidence: 99%

Physical training and metabolic supplementation reduce spontaneous atherosclerotic plaque rupture and prolong survival in hypercholesterolemic mice

Napoli

Williams-Ignarro²,

Nigris³

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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Moderate physical exercise (PE) combined with metabolic treatment (MT) (antioxidants and L-arginine) are well known to reduce atherosclerotic lesion formation in hypercholesterolemic mice. However, the long-term beneficial effects on unstable atheroma remain poorly understood. We started early PE training in large groups of 6-week-old hypercholesterolemic mice (by graduated swimming) alone or in combination with nutritional supplementation (1.0% vitamin E added to the chow and 0.05% vitamin C and 6% L-arginine added to the drinking water). Inactive controls did not receive PE. The spontaneous development of atherosclerotic plaque rupture (associated with advanced atherosclerosis) and survival rates were evaluated. Moderate PE elicited an increase in plasma levels of nitric oxide. Early combined treatment with PE and MT in the hypercholesterolemic mice significantly reduced lesions (also detected noninvasively at 10 months) and spontaneous atherosclerotic plaque rupture and prolonged survival more effectively than each intervention alone. Thus, early concerted actions of MT and PE improve the natural history of atherosclerotic lesions and reduce the plaque instability in hypercholesterolemic mice.antioxidants ͉ nitric oxide ͉ physical exercise ͉ L-arginine

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“…Clinically, some of these techniques include intravascular optical coherence tomography (OCT) and near-infrared refl ectance spectroscopy ( 9,(13)(14)(15)(16)(17)(18). These methods, which provide signifi cantly improved information about plaque structure and composition, are currently under investigation in large-scale clinical studies ( 19,20 ).…”

Section: Atherosclerotic Apoe-defi Cient Mouse Modelmentioning

confidence: 99%

Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice

Lim

Kratzer

Barry

et al. 2010

Journal of Lipid Research

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Detection of vulnerable plaque in a murine model of atherosclerosis with optical coherence tomography

Abstract: These findings suggest that OCT holds promise for the identification of features defining vulnerable plaque including fibrous cap thickness, lipid core size, and the percentage of lipid content.

Cited by 62 publications

References 62 publications

Ex vivo imaging of chronic total occlusions using forward‐looking optical coherence tomography

Ex vivo imaging of chronic total occlusions using forward‐looking optical coherence tomography

Physical training and metabolic supplementation reduce spontaneous atherosclerotic plaque rupture and prolong survival in hypercholesterolemic mice

Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice

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