Detection of ureaplasmas and bacterial vaginosis associated bacteria and their association with non-gonococcal urethritis in men

Abstract

No aetiology is found in up to 40% of men with symptomatic urethritis. Male partners of women with bacterial vaginosis (BV) may be at higher risk of non-gonococcal urethritis (NGU). The aim of this study was to examine the role of BV associated bacteria in first-void urine (FVU) in 97 asymptomatic men without urethritis (controls) and 44 men (cases) with NGU including 20 men with idiopathic urethritis (IU) attending a Swedish STD-clinic between January and October 2010. BV-associated bacteria and ureaplasmas were detected by quantitative PCR assays. All BV associated bacteria, except Megasphaera -like type 1, were strongly positively correlated with U . urealyticum p<0.005 and even stronger with the combined U . urealyticum and U . parvum load (p<0.0005) suggesting that ureaplasma induced elevated pH may stimulate the growth of BV associated bacteria. No statistically significant differences were found between IU cases and controls in the prevalence or load of BV associated bacteria or ureaplasmas. In multiple logistic regression, Megasphaera -like type 1 was associated with IU (p = 0.03), but most positive FVU samples contained very few bacteria and the finding may not be clinically relevant.

Changes in the vaginal microbiota following antibiotic treatment for Mycoplasma genitalium, Chlamydia trachomatis and bacterial vaginosis

“…related to CST-IV. This is in accordance with our previous findings in men where the load of BV associated bacteria was positively correlated with the ureaplasma load [ 43 ]…”

“…related to CST-IV. This is in accordance with our previous findings in men where the load of BV associated bacteria was positively correlated with the ureaplasma load [43] The acidic environment created by the vaginal lactobacilli, particularly L. crispatus [44] could diminish the activity of azithromycin. However, we did not see more ureaplasma persistence in the CST-I dominated patients, on the contrary, patients with CST-III and CST-IV showed a higher proportion of persistent U. parvum than CST-I dominated patients.…”

Bakteriyel vajinoz ve tedavisinin cinsel fonksiyonlar üzerine etkileri: Bir kesitsel anket çalışması

“…It was concluded in this study that bacterial vaginosis affects the emotional, physical, social and sexual lives of patients in different levels. Patients have stated that they feel dirty and bad, were ashamed of their condition and avoided sexual intercourse [17]. In another study carried out Donders and colleagues, it was stated that abnormal vaginal microbiome caused vulvodynia, the most frequent cause was bacterial vaginosis, and this in turn caused sexual dysfunction in patients [18].…”

“It’s just an issue and you deal with it… you just deal with it, you move on and you do it together.”: Men’s experiences of bacterial vaginosis and the acceptability of male partner treatment

“…Current knowledge suggests that men do not generally experience BV symptoms. However, 30 year old case reports describe three men experiencing Gardnerella vaginalis-associated balanoposthitis (malodourous balanitis) [73] and there is very recent interest in whether BVABs may cause urethral symptoms in men [74]. This indicates a growing consideration of how the presence of and exposure to BVABs may physically affect men.…”