Detection of tissue plasminogen activator (t‐PA) and plasminogen activator inhibitor 2(PAI‐2) in gingival crevicular fluid from healthy, gingivitis and periodontitis patients

Yin, Xiaomin; Bunn, Clive L.; Bartold, P. Mark

doi:10.1034/j.1600-051x.2000.027003149.x

Cited by 54 publications

(49 citation statements)

References 17 publications

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“…Increased levels of the plasminogen-activator-inhibitors were previously detected in inflammed gingival and periodontal tissues. 15,16 Our study showed a significant association between the carriage of the allele 4G (deletion) polymor-…”

Section: Discussionmentioning

confidence: 59%

Plasminogen-activator-inhibitor-1 promoter polymorphism as a risk factor for adult periodontitis in non-smokers

et al. 2002

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Periodontal diseases belong to the most common chronic disorders affecting mankind. Smoking and impaired plasminogen activation with hypercoagulation and fibrinolysis inhibition have been proposed as having a role in predisposition to these diseases. We investigated relationships among adult periodontitis, smoking, and a variation in the deletion/insertion (4G/5G) promoter polymorphism of the plasminogen-activator-inhibitor-1 (PAI-1) gene in 304 Caucasian subjects. An association was detected between the deletion (4G) allele (and 4G/4G genotype)

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Section: Discussionmentioning

confidence: 59%

Plasminogen-activator-inhibitor-1 promoter polymorphism as a risk factor for adult periodontitis in non-smokers

et al. 2002

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“…Because of very low levels, these results should be interpreted with caution. It is also reported that TNF-α is more present in active lesions [40,41]. In another study TNF-α was detected in 37 of 42 implant samples, but no correlations between the severity of peri-implant inflammation and the presence of TNF-α were found [13].…”

Section: Periodontitis and Peri-implantitismentioning

confidence: 98%

A Comparison Of Il-1β, E2 (Pge2), Pai-2 and Tnf-Α Levels in Gingival Crevicular Fluid (Gcf) and Peri-Implant Crevicular Fluid (Picf) from Groups of Patients with Healthy Teeth, Healthy Implants, Periodontitis and Peri-Implantitis

Ketabi¹,

Friese²,

Weber³

2017

Dentistry

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Objectives: The aim of this study was to analyse simultaneously four markers in gingival crevicular fluid (GCF) and peri-implant crevicular fluid (PICF) from 41 patients in four different groups over a period of six months in order to establish profiles indicating quantitative ratio and potential correlations. Material and Methods:We compared levels of interleukin-1 beta (IL-1ß), prostaglandin E2 (PGE2), specific plasminogen activator inhibitor 2 (PAI-2) and tumor necrosis factor-alpha (TNF-α) in GCF and PICF from four groups of patients: healthy teeth (n=10), healthy implants (n=10), periodontitis (n=11) and peri-implantitis (n=10). Clinical parameters including bacterial flora were quantified by PCR-analysis. The concentration in GCF/PICF of IL-1β, PAI-2, E2 (PGE2) was determined by ELISA, TNF-α by Western blot analysis.Results: Healthy teeth showed significantly higher levels of IL-1β than healthy implants. The mean level of E2 (PGE2) for healthy teeth was twice as high as for healthy implants. Periodontitis and peri-implantitis sites showed highly increased secretion of IL-1ß and E2 (PGE2) resulting in significantly higher levels of IL-1ß in periodontits than in peri-implantitis. Highest TNF-α levels showed in the peri-implantitis group, lowest in healthy teeth. Lowest concentrations of PAI-2 appeared in peri-implantitis, highest in healthy implants. Conclusions:Within the limits of the study it could be hypothesized that the significantly higher levels of IL-1ß and E2 (PGE2) for healthy teeth than for healthy implants could in part be due to the lack of periodontal ligament cells around implants. Another possible explanation could be the anti-inflammatory property of titanium surfaces of implants.

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“…The alteration in the pattern of PA distribution, according to periodontal status, suggests that PA is involved in the periodontal homeostasis 58 . The levels of tPA and the plasminogen activator inhibitor-2 (PAI-2) are greater in gingival crevicular fluid of patients with periodontitis than in periodontally healthy patients 59 .…”

Section: Immunosenescence and Periodontal Cells Interactionmentioning

confidence: 99%

Effects of Human Ageing on Periodontal Tissues

Hebling¹

2012

Periodontal Diseases - A Clinician's Guide

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Detection of tissue plasminogen activator (t‐PA) and plasminogen activator inhibitor 2(PAI‐2) in gingival crevicular fluid from healthy, gingivitis and periodontitis patients

Abstract: This study indicates that t-PA and PAI-2 may play a significant rôle in the periodontal tissue destruction and tissue remodeling and that t-PA and PAI-2 in GCF may be used as clinical markers to evaluate the periodontal diseases and assess treatment.

Cited by 54 publications

References 17 publications

Plasminogen-activator-inhibitor-1 promoter polymorphism as a risk factor for adult periodontitis in non-smokers

Plasminogen-activator-inhibitor-1 promoter polymorphism as a risk factor for adult periodontitis in non-smokers

A Comparison Of Il-1β, E2 (Pge2), Pai-2 and Tnf-Α Levels in Gingival Crevicular Fluid (Gcf) and Peri-Implant Crevicular Fluid (Picf) from Groups of Patients with Healthy Teeth, Healthy Implants, Periodontitis and Peri-Implantitis

Effects of Human Ageing on Periodontal Tissues

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