Detection of the iron complexes with hydrolysis products of cephalexin and cefradine upon high‐performance liquid chromatography/electrospray ionization mass spectrometry analysis

Dudkowska, Joanna; Frańska, Magdalena; Frański, Rafał

doi:10.1002/rcm.8073

Cited by 5 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hydrophobic interactions were supposed between the analyte and the adsorbents. To optimize the effect of carbon chain on the cephalosporins enrichment, three kinds of modifications, including C 2 , C 8 , and C 18 , were carried on for the MPS [31]. Quantitative determination of the carbon percentage for the MPS‐11 with different functional groups was achieved by the elemental analysis.…”

Section: Resultsmentioning

confidence: 99%

Preparation of highly responsive monodisperse magnetic porous silica microspheres for the enrichment of cephalosporins in wastewater

Ruiting

Chang

Chen

2020

J of Separation Science

View full text Add to dashboard Cite

Highly responsive monodisperse microsized magnetic silica microspheres were synthesized through the electrostatic self-assembly method. Monodisperse composite silica microspheres were prepared by depositing tetraethyl orthosilicate prepolymer on the glycidyl methacrylate-co-ethylene glycol dimethacrylate microspheres. After calcination, the organic moiety was removed and macroporous microspheres were left on the silica particles. To increase the selectivity, magnetic porous silica was bonded with different alkyl functional groups. The morphology, particle size distribution, magnetic properties, and functional groups of magnetic porous silica microspheres were characterized by scanning electron microscopy, coulter counter, vibrating sample magnetometry, X-ray diffraction, and elemental analysis, respectively. Extraction parameters, including pH, the salt concentration of the adsorbed solution, adsorption time, elution solvent, and time, were systematically investigated. The developed magnetic solid-phase extraction method, combined with high-performance liquid chromatography, presented reasonable linearity (0.5-10 µg/mL), low limit of detection (45.0-108.0 ng/mL), and high selectivity for cefadroxil, cefquinome, and cefradine. It was operated in three kinds of cephalosporins detection from wastewater with the relative recovery rates in the range of 86.5-97.0%. These results indicated that the synthesized magnetic microsphere is a promising adsorbent for the enrichment of cephalosporins.

show abstract

Section: Resultsmentioning

confidence: 99%

Preparation of highly responsive monodisperse magnetic porous silica microspheres for the enrichment of cephalosporins in wastewater

Ruiting

Chang

Chen

2020

J of Separation Science

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…In addition to acid–base chemistry and the compound structure, the presence of metal ions, ,,− minerals, and organic matter in surface waters is expected to influence the fate of β-lactam antibiotics. For example, previous studies have shown that Zn(II), Cu(II), ,,,, Co(II), Mn(II), and Fe(III) , ions can promote hydrolysis of β-lactam antibiotics, as well as that the redox properties of the metal ion can promote oxidation of parent and transformation product compounds. Furthermore, β-lactam antibiotics have been shown to adsorb to soil particles, including clays. ,− Adsorption to clay particles has been considered for β-lactam removal from wastewater solution. , Other antibiotic classes such as sulfonamides, − tetracyclines, − and fluoroquinolones, − have been well studied with respect to their mechanisms of adsorption and degradation.…”

Section: Introductionmentioning

confidence: 99%

Probing the Fate of Different Structures of Beta-Lactam Antibiotics: Hydrolysis, Mineral Capture, and Influence of Organic Matter

Klein

Sarri

Kelch

et al. 2021

ACS Earth Space Chem.

View full text Add to dashboard Cite

Beta-lactam antibiotics, which are used extensively in human and veterinary applications, are commonly detected in surface waters. To examine how the distinct structures of different generations of beta-lactam antibiotics can influence their persistence or degradation in environmental aqueous media, we examined the fate of two penams (amoxicillin and cloxacillin) and two cephems (cephalexin and ceftriaxone) at pH 5.0 and pH 7.0. By contrast to the lack of hydrolysis of the penam antibiotics at both pHs, we observed hydrolysis of cephalexin at pH 7.0 (t 1/2 = 12 d) and ceftriaxone at pH 5.0 (t 1/2 = 2.8 d). Using highperformance liquid chromatography coupled with a diode array detector or a high-resolution mass spectrometer, we were able to confirm thiotriazinone and 3-desacetyl cefotaxime as major hydrolysis products of ceftriaxone, and propose the hydrolytic cleavage of the benzene and cephem moieties from cephalexin. In addition, we studied the effects of smectite clay particles suspended in solutions without or with dissolved organic matter. The adsorption capacity of the clay was 4-to 9-fold higher at pH 7.0 than at pH 5.0. Subsequent X-ray diffraction analysis revealed that the antibiotic adsorption was not within the clay interlayer nanopores but occurred primarily on the external clay surfaces. The addition of dissolved organic matter interfered with the adsorption of a cephem antibiotic (ceftriaxone) on the clay, but the adsorption of a penam antibiotic (amoxicillin) remained unaffected. We employed molecular modeling simulations to probe the mechanisms of adsorption on the mineral surface. Our findings offer new insights on how the compound structures can dictate different fates of the beta-lactam class of antibiotics in environmental media.

show abstract

Evaluation of the Cefalexin Drug Degradation Profile in Pharmaceutical Capsule Forms Based on Forced Degradation Studies

2022

View full text Add to dashboard Cite

Detection of the iron complexes with hydrolysis products of cephalexin and cefradine upon high‐performance liquid chromatography/electrospray ionization mass spectrometry analysis

Abstract: The detection of the complexes between the hydrolysis products of cephalosporins and iron may have a positive impact on the sensitivity and specificity of HPLC/ESI-MS analyses of the hydrolysis products of some cephalosporins.

Cited by 5 publications

References 33 publications

Preparation of highly responsive monodisperse magnetic porous silica microspheres for the enrichment of cephalosporins in wastewater

Preparation of highly responsive monodisperse magnetic porous silica microspheres for the enrichment of cephalosporins in wastewater

Probing the Fate of Different Structures of Beta-Lactam Antibiotics: Hydrolysis, Mineral Capture, and Influence of Organic Matter

Evaluation of the Cefalexin Drug Degradation Profile in Pharmaceutical Capsule Forms Based on Forced Degradation Studies

Contact Info

Product

Resources

About