Detection of the Hyaluronan Receptor CD44 in the Bovine Oviductal Epithelium

Bergqvist, Ann-Sofi; Yokoo, Masaki; Båge, Renée; Sato, Eimei; Rodríguez‐Martínez, H.

doi:10.1262/jrd.17010

Cited by 12 publications

(7 citation statements)

References 55 publications

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“…The general histological changes in four different segments of buffalo oviducts during both the follicular and luteal phases in this study were similar to the previous observations in the bovine oviduct (Suarez et al. 1997; Bergqvist et al. 2005a,b).…”

Section: Discussionsupporting

confidence: 90%

Light and Scanning Electron Microscopic Studies of Oviductal Epithelium in Thai Swamp Buffalo (Bubalus bubalis) at the Follicular and Luteal Phases

Tienthai

Sajjarengpong²,

Techakumphu

2009

Reprod Domestic Animals

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The purpose of this study was to investigate the morphological changes in the epithelium of Thai swamp buffalo oviducts at the follicular and luteal phases by histological technique and scanning electron microscopy. The samples from the infundibulum, ampulla, isthmus and uterotubal junction (UTJ) of the oviduct were taken immediately after slaughter at the local abattoir. Noticeable cyclic changes were observed on the epithelial surface of the infundibulum and ampulla, but few changes were present in the isthmus and UTJ. At the follicular phase, the epithelium of infundibulum and ampulla were densely covered with ciliated cells whose cilia concealed the apical processes of the secretory cells. In contrast, the secretory cells dominated in the epithelium at the luteal phase and most of the ciliated cells were hidden by the bulbous processes of these cells. In the isthmus and UTJ at the follicular and luteal phases, the secretory cells were almost flat or gently rounded and covered with numerous microvilli at their apical surface. In conclusion, the histological and ultrastructural observation of Thai swamp oviduct epithelium revealed marked cyclic changes in the cellular differences associated with the main functions of segmental variations.

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Section: Discussionsupporting

confidence: 90%

Light and Scanning Electron Microscopic Studies of Oviductal Epithelium in Thai Swamp Buffalo (Bubalus bubalis) at the Follicular and Luteal Phases

Tienthai

Sajjarengpong²,

Techakumphu

2009

Reprod Domestic Animals

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“…CD44 is a single-pass trans-membrane glycoprotein located on the surface of most vertebrate cells [113]. It has been detected in various segments of the reproductive tract in bovine, ovine, mouse, mare and human under normal physiological [96], [97], [114], [115] or pathological conditions such as neoplastic endometrium in human [116]. CD44 is also detected during early stages of embryo development in mouse, bovine and human [117], [118].…”

Section: Cluster Domain 44 (Cd44)mentioning

confidence: 99%

Cytokines, growth factors and macromolecules as mediators of implantation in mammalian species

Raheem

2018

International Journal of Veterinary Science and Medicine

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Implantation is one of the most critical steps in mammalian reproduction and implantation failure constitutes a major cause of infertility in both animals and humans. The mechanism of implantation is exclusively under the control of ovarian steroids progesterone and oestrogen whose actions are mediated in a complex phenomenon that involves a number of cytokines and growth factors. According to a plethora of literature on implantation in mammalian species, prominent of these cytokines and growth factor playing crucial roles in implantation include integrin, osteopontin, integrin, insulin-like growth factor and leukaemia inhibitory factor. Others are cluster domain 44, hyaluronan system and many non-adhesive molecules such as glycoprotein mucin 1. In this review, the specific roles played by these molecules are expatiated. Generally, they function as adhesive molecules that facilitate attachment of ligands/proteins on the trophectoderm to their respective receptors on endometrial luminal epithelia or vice versa. Sometimes, they also function as signalling molecules that enhance communication between implanting blastocyst and receptive endometrium. This is of particular importance in embryo culture and embryo transfer where in vitro derived blastocyst unlike the in vivo condition, is not exposed to these substances and hence, their absence may be partly responsible for the low implantation rate observed in the surrogate. Appreciation of the roles played by these cytokines, growth factors and molecules as revealed in this review will spur further research on these topics, facilitate their inclusion in embryo culture media (if positively required) and are considered as vital aspect while developing strategies to improve fertility.

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“…The in vitro HA‐bound spermatozoa were reported to be morphologically similar to in vivo zona pellucida‐bound spermatozoa, also had low levels of DNA fragmentation, fewer chromosomal aneuploidies and low levels of apoptotic markers (Chun et al., 2005; Huszar et al., 2006, 2007; Torabi et al., 2017). The HBA is thought to predict sperm quality through the ability of sperm binding to immobilised HA via receptors, including HABP1, SPAM1 and CD44 on the cell surface (Bergqvist et al., 2005; Fouladi‐Nashta et al., 2017; Ghosh & Datta, 2003; Rodriguez‐Martinez et al., 2016; Saindon & Leclerc, 2018).…”

Section: Introductionmentioning

confidence: 99%

Sperm binding to hyaluronan is an excellent predictor of Nili‐Ravi buffalo bull fertility

et al. 2021

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This study reports the first evaluation of sperm hyaluronan binding assay (HBA) for predicting the fertility of Nili‐Ravi buffalo bulls in relation to standard parameters of sperm quality. Cryopreserved semen doses of low (n = 6), medium (n = 3) and high fertility (n = 8) bulls based on their respective return rates were used. Significantly, more spermatozoa bound to hyaluronan from the most fertile bulls (57.15% ± 1.44) compared with medium (42.46% ± 1.08) and low fertility bulls (29.70% ± 0.78). A strongly positive correlation (r = .824, p < .01) was found between HBA and fertility that predicts a 67.9% variability (r2 = .679, p < .01) in fertility. HBA was also strongly positively correlated with sperm viability (r = .679, p < .01) followed by their live/dead ratio (r = .637, p < .01), uncapacitated spermatozoa (r = .631, p < .01), normal apical ridge (r = .459, p < .01), motility (r = .434, p < .01), mature spermatozoa with low residual histones (r = .364, p < .01), high plasma membrane integrity (r = .316, p < .01) and nonfragmented DNA levels (r = .236, p < .05). It was negatively correlated with spermatozoa having reacted acrosome (r = −.654, p < .01). A fertility model built using a combination of sperm HBA and either sperm livability or viability predicts, respectively, 86.1% (r2 = .861, p < .01) and 85.9% (r2 = .859, p < .01) variability in buffalo bull fertility. In conclusion, sperm HBA may prove to be a single robust predictor of Nili‐Ravi buffalo bull fertility.

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Detection of the Hyaluronan Receptor CD44 in the Bovine Oviductal Epithelium

Cited by 12 publications

References 55 publications

Light and Scanning Electron Microscopic Studies of Oviductal Epithelium in Thai Swamp Buffalo (Bubalus bubalis) at the Follicular and Luteal Phases

Light and Scanning Electron Microscopic Studies of Oviductal Epithelium in Thai Swamp Buffalo (Bubalus bubalis) at the Follicular and Luteal Phases

Cytokines, growth factors and macromolecules as mediators of implantation in mammalian species

Sperm binding to hyaluronan is an excellent predictor of Nili‐Ravi buffalo bull fertility

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