Detection of the association between a deletion polymorphism in the gene encoding angiotensin I-converting enzyme and advanced diabetic retinopathy

Matsumoto, Akinori; Iwashima, Yasunori; Abiko, Atsuko; Morikawa, Akizuki; Sekiguchi, Masatomo; Eto, Masatoshi; Makino, Isao

doi:10.1016/s0168-8227(00)00194-7

Cited by 39 publications

(22 citation statements)

References 24 publications

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“…During the past decade, there has been a growing interest in the study of the ACE gene I/D polymorphism as a potential risk factor for diabetic retinopathy (DR) after a report that more than half of the plasma ACE variation levels between individuals were under the influence of the I/D polymorphism. 25,26 Confirmation of genetic association has been difficult for many reasons. Among widely cited explanations are the multifactorial nature of the diseases, insufficient sample size, and criteria of selection which may lead to false negative results.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme gene insertion/deletion polymorphism studies in Asian Indian pregnant women biochemically identifies gestational diabetes mellitus

Khan

Jahan

Hasan

et al. 2013

J Renin Angiotensin Aldosterone Syst

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Introduction: Gestational diabetes mellitus (GDM) is defined as glucose intolerance first recognized during pregnancy. Insertion/deletion (I/D) polymorphism of a 287 bp Alu repetitive sequence in intron 16 of the angiotensin-converting enzyme (ACE) gene has been widely investigated in Asian Indian populations with different ethnic origins. The present study examined possible association between I/D polymorphism of the ACE gene and GDM in Asian Indian pregnant women. Methods: A total of 200 pregnant women (100 GDM and 100 non-GDM) were recruited in this study and I/D polymorphism of a 287 bp Alu1 element inside intron 16 of the ACE gene was examined by polymerase chain reaction (PCR)-based gel electrophoresis. Result: The distribution of the variants like II, ID, and DD genotypes of ACE gene showed differences between normal GDM versus non-GDM subjects, and the frequency of the ID+ DD Vs II genotype was significant (p=0.0002) in the GDM group. Conclusion: ACE gene polymorphism was associated with GDM in Asian Indian pregnant women.

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Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme gene insertion/deletion polymorphism studies in Asian Indian pregnant women biochemically identifies gestational diabetes mellitus

Khan

Jahan

Hasan

et al. 2013

J Renin Angiotensin Aldosterone Syst

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“…Complication assessment Fundoscopic examinations were performed through dilated pupils by ophthalmologists in each hospital and classified as: (1) no evidence of diabetic retinopathy; (2) simple diabetic retinopathy (SDR); and (3) pre-proliferative retinopathy or proliferative retinopathy [8]. This classification corresponds to levels 10, 21/10 to 31/31, 41/<41 to 51/51 and 60+/<60+ to 60+/60+, as defined in the Wisconsin study [9][10][11].…”

Section: Subjectsmentioning

confidence: 99%

Fulminant type 1 diabetes as a high risk group for diabetic microangiopathy—a nationwide 5-year-study in Japan

et al. 2007

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Aims/hypothesis The aim of the present study was to assess the development of microangiopathy in patients with fulminant type 1 diabetes, a novel subtype of type 1B diabetes. Materials and methods In a nationwide survey, we followed 41 patients with fulminant type 1 diabetes and 76 age-and sex-matched patients with type 1A diabetes for 5 years. The following data were recorded every 12 months after the onset of diabetes: seven-point blood glucose concentrations, HbA 1c level, urinary albumin excretion, serum C-peptide level, blood pressure, daily dosages of insulin, frequency of severe hypoglycaemic episodes, and neurological and fundoscopic examination. ResultsThe 5-year cumulative incidence of microangiopathy was 24.4% in fulminant type 1 diabetes and 2.6% in type 1A diabetes. In longitudinal studies using the KaplanMeier method, the cumulative incidence of each form of microangiopathy was significantly higher in fulminant type 1 diabetes than in type 1A diabetes; retinopathy was 9.8% vs 0% (p=0.014), nephropathy 12.2% vs 2.6% (p=0.015) and neuropathy 12.2% vs 1.3% (p=0.010), respectively. Mean HbA 1c levels were similar in the fulminant and type 1A diabetes groups during the follow-up periods. However, the mean M-value, mean insulin dosages and the frequency of severe hypoglycaemic episodes were significantly higher, and the mean postprandial C-peptide level was significantly lower in the fulminant type 1 diabetes group.

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“…These include the nitric oxide synthases (NOS) that mediate vasodilation and the endothelins (ETs) that are vasoconstrictors. Angiotensin-converting enzyme (ACE), which converts angiotensinogen to angiotensin, is another important mediator of vasoconstriction and homeostasis; however, studies to date on genetic markers of members [48][49][50][51][52][53][54][55][56] of this signalling pathway have not shown definitive evidence of direct genetic risk (see Table 1). …”

Section: Mhc and Immunity Markersmentioning

confidence: 99%

Molecular genetics of microvascular disease in diabetic retinopathy

Warpeha

Chakravarthy

2003

Eye

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Detection of the association between a deletion polymorphism in the gene encoding angiotensin I-converting enzyme and advanced diabetic retinopathy

Cited by 39 publications

References 24 publications

Angiotensin-converting enzyme gene insertion/deletion polymorphism studies in Asian Indian pregnant women biochemically identifies gestational diabetes mellitus

Angiotensin-converting enzyme gene insertion/deletion polymorphism studies in Asian Indian pregnant women biochemically identifies gestational diabetes mellitus

Fulminant type 1 diabetes as a high risk group for diabetic microangiopathy—a nationwide 5-year-study in Japan

Molecular genetics of microvascular disease in diabetic retinopathy

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