Detection of TET2, KRAS and CBL variants by Next Generation Sequencing and analysis of their correlation with JAK2 and FLT3 in childhood AML

Determination of CEBPA mutations by next generation sequencing in pediatric acute leukemia

“…Compared with adult leukemia, there were fewer studies of gene mutations in pediatric leukemia patients. We previously reported the frequencies of TET2, CBL, and KRAS mutations by using NGS in pediatric AML patients and the frequencies of FLT3-ITD and FLT3-TKD mutations in acute leukemia patients (18).…”

“…Therefore, fl uorescence of all the other samples was diagramed relatively to this sample. Fluorescence signals were analyzed, and significant differences were used as indicators of the mutations (15)(16)(17)(18).…”